Gut dysbiosis may be implicated in the pathogenesis of IgA nephropathy (IgAN) through immune and/or metabolite pathways. Fecal microbiota transplantation (FMT) could reestablish the micro-ecological balance in IgAN, although this has never been attempted before. We explored whether FMT could be efficacious in treating IgAN in two patients with refractory IgAN. Two Chinese female patients with IgAN failed to achieve clinical remission after receiving several rounds of immunosuppressive therapy and suffered from unbearable adverse effects...

There is growing evidence that circular RNAs (circRNAs) play a vital role in many kinds of diseases, including erectile dysfunction (ED). Nevertheless, the role of circRNAs in cavernous nerve-damaging ED (CNI-ED) is unknown. Here, we aimed to discover novel circRNAs, probed their potential role in the CNI-ED, and construct a ceRNA network of circRNAs. Twelve male Sprague Dawley rats were randomly divided into 2 groups by us: bilateral cavernous nerve crush (BCNC) and control groups....

Preeclampsia (PE) is a huge threat to pregnant women. Our previous study demonstrated that long non-coding RNA (lncRNA) NR_002794 was highly expressed in placentas of PE patients and could regulate the phenotypes of trophoblast cells. However, the downstream regulatory mechanisms of NR_002794 remain unknown. In this text, some potential downstream targets or signaling pathways of NR_002794 were identified through RNA sequencing (RNA-seq) and bioinformatics analysis in SWAN71 trophoblast cells. Western blot assay demonstrated that NR_002794...

This study aimed to reveal the mechanism of miR-146b-5p in the differentiation of bone marrow mesenchymal stem cells (BMSCs) derived from children with aplastic anemia (AA). Here, we found that miR-146b-5p was highly expressed in BMSCs from children with AA, and the BMSCs surface markers expressions in BMSCs derived from children with AA and the healthy controls exerted no significant differences. Besides, the overexpression of miR-146b-5p in normal human-derived BMSCs promoted the adipogenic differentiation of...

Background: Various studies have examined the psychological ‘typhoon eye’ and ‘ripple’ effects in mental disorders following COVID-19. However, these studies only considered the disorders as entities and assessed severity, and overlooked the differences in specific symptoms of disorders. Objectives: This aim of the study is to assess the psychological typhoon eye and ripple effects at the symptom-level in posttraumatic stress disorder (PTSD), which is considered as a common psychopathology following the COVID-19 epidemic. Method: In...

Inherited thrombocytopenia 2 (THC2) is difficult to diagnose due to the lack of specific clinical characteristics and diagnostic methods. To identify potential plasma protein biomarkers for THC2, we collected the plasma samples from a THC2 family (9 THC2 and 15 non-THC2 members), enriched the medium and low abundant proteins using Proteominer and analyzed the protein profiles using the liquid chromatography-mass spectrometry in data independent acquisition mode. Initially, we detected 784 proteins in the plasma samples...

We herein describe the comprehensive investigation of the complexation behavior of a guanidinium-modified calix[5]arene pentaisohexyl ether (GC5A) with a variety of typical luminescent dyes. Fluorescein, eosin Y, rose bengal, tetraphenylporphine sulfonate and sulfonated aluminum phthalocyanine were employed as classical aggregation-induced quenching dyes. 2-(p-Toluidinyl)naphthalene-6-sulfonic acid and 1-anilinonaphthalene-8-sulfonic acid were selected as representatives of intramolecular charge-transfer dyes. Phosphated tetraphenylethylene was involved as the classical aggregation-induced emission dye. Sulfonated acedan representing one example of two-photon fluorescent probes, was...

(2018). Assembly-enhanced molecular recognition of calix[6]arene. Supramolecular Chemistry: Vol. 30, Calix 2017, pp. 562-567.

(2015). Molecular recognition of amphiphilic p-sulfonatocalix[4]arene with organic ammoniums. Supramolecular Chemistry: Vol. 27, Ninth International Symposium of Macrocyclic and Supramolecular Chemistry (ISMSC-9), pp. 336-345.

A supramolecular self-assembly has been constructed by perylene-bridged bis(β-cyclodextrin)s with water-soluble porphyrin through hydrophobic interactions, showing strong excitonic coupling interactions between perylene backbones and included porphyrins.

A linear supramolecular ternary polymer based on two host–guest interactions in an orthogonal way was constructed, by taking advantage of the distinguishable binding properties between cyclodextrin and calixarene.

A novel water-soluble perylene bisimide derivative 1 was synthesized with two permethyl-β-cyclodextrin grafts at the imide nitrogens, and its structure was identified by NMR, Fourier transform infrared spectroscopy (FT-IR), matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS), and elemental analysis. Its aggregation behavior in water and organic solutions was further investigated by UV−vis, fluorescence, and 1H NMR spectra, showing that 1 exhibits strong π···π aggregation in water. Especially, the aggregation and optical properties were comprehensively compared...

(2014). Binding behaviour and solubilisation of p-sulfonatocalixarenes to cinchona alkaloids. Supramolecular Chemistry: Vol. 26, No. 10-12, pp. 809-816.

The binding behaviors and thermodynamic origins of p-sulfonatocalix[4]arene (C4AS) and p-sulfonatocalix[5]arene (C5AS) with methyl viologen (MV2+) have been investigated by the methods of isothermal titration calorimetry, NMR, and cyclic voltammetry, showing that the binding abilities of C4AS and C5AS and their host selectivity are dramatically pH-controlled, which is closely discussed from the viewpoint of thermodynamics. Moreover, the radical form of MV+• can also be effectively included by C4AS and C5AS.

The complex stability constants (KS) and thermodynamic parameters (ΔH° and TΔS°) for 1:1 intermolecular complexation of three water-soluble calixarenes, that is, p-sulfonato calix[4]arene (C4AS), p-sulfonato thiacalix[4]arene (TCAS), and p-sulfonato calix[5]arene (C5AS), with dipyridines (4-DPD and 2-DPD) and 1,10-phenanthroline (Phen) have been determined by means of titration microcalorimetry in an acidic buffer solution (pH = 2.0) at 298.15 K, and their binding modes have been investigated by 1H NMR and 2D ROESY NMR spectroscopy. The results...