29 Works

Distinct photophysical behaviour and transport of cell-impermeable [Ru(bpy)2dppz]2+ in live cells using cucurbit[7]uril as a delivery system

Meenakshi Shinde, Soniya Rao, Shridhar Gejji & Anupa Kumbhar
We have successfully demonstrated the delivery of a cell-impermeable [Ru(bpy)2dppz]2+ complex across the cell membrane in live cells using a cucurbit[7]uril molecular container.

A Bambusuril Macrocycle that Binds Anions in Water with High Affinity and Selectivity

Mirza Arfan Yawer, Vaclav Havel & Vladimir Sindelar
One ring binds them all: A bambusuril macrocycle is able to selectively capture a large number of different inorganic anions in water. The high stability of the resulting inclusion complexes is due t...

endo-Functionalized molecular tubes: selective encapsulation of neutral molecules in non-polar media

Guobao Huang, Arto Valkonen, Kari Rissanen & Wei Jiang
Four endo-functionalized molecular tubes show high binding affinity and selectivity to neutral molecules.

Water-mediated inclusion of benzoates and tosylates inside the bambusuril macrocycle

Angel E. Kaifer, Vaclav Havel, Vladimir Sindelar & Marek Necas
A supramolecular complex between benzoates and a bambusuril crystallizes out immediately after mixing in chloroform but only in the presence of residual water molecules. In this complex each of the two portals of the macrocycle is occupied by one benzoate. Carboxylate groups are connected through hydrogen bo

Guest Binding Dynamics with Cucurbit[7]uril in the Presence of Cations

Hao Tang, Denis Fuentealba, Young Ho Ko, Narayanan Selvapalam, Kimoon Kim & Cornelia Bohne
The binding dynamics of R-(+)-2-naphthyl-1-ethylammonium cation (NpH+) with cucurbit[7]uril (CB[7]) was investigated. Competitive binding with Na+ or H3O+ cations enabled the reaction to be slowed down sufficiently for the kinetics to be studied by fluorescence stopped-flow experiments. The binding of two Na+ cations to CB[7], i.e., CB[7]·Na+ (K01 = 130 ± 10 M–1) and Na+·CB[7]·Na+ (K02 = 21 ± 2 M–1), was derived from the analysis of binding isotherms and the kinetic studies. NpH+ binds...

Anion-Free Bambus[6]uril and Its Supramolecular Properties

Jan Svec, Michal Dusek, Karla Fejfarova, Peter Stacko, Petr Klán, Angel E. Kaifer, Wei Li, Edita Hudeckova & Vladimir Sindelar
Abstract Methods for the preparation of anion-free bambus[6]uril (BU6) are presented. They are based on the oxidation of iodide anion, which is bound inside the macrocycle, utilizing dark oxidation...

High Fidelity Kinetic Self-Sorting in Multi-Component Systems Based on Guests with Multiple Binding Epitopes

Pritam Mukhopadhyay, Peter Y. Zavalij & Lyle Isaacs
The molecular recognition platforms of natural systems often possess multiple binding epitopes, each of which has programmed functional consequences. We report the dynamic behavior of a system comprising CB[6], CB[7], and guests cyclohexanediammonium (1) and adamantanealkylammonium (2) that we refer to as a two-faced guest because it contains two distinct binding epitopes. We find that the presence of the two-faced guestjust as is observed for protein targeting in vivodictates the kinetic pathway that the system...

Cucurbit[7]uril⋅Guest Pair with an Attomolar Dissociation Constant

Liping Cao, Marina Šekutor, Peter Y. Zavalij, Kata Mlinarić-Majerski, Robert Glaser & Lyle Isaacs
A perfect pair: The complex between cucurbit[7]uril (CB[7]) and diamantane-4,9-bis(NMe3) (6) has a dissociation constant of 1.4Ã10â18âM in aqueous solution. Competition experiments show that CB[7]â6 ...

Real-time analysis of multiple anion mixtures in aqueous media using a single receptor

Vaclav Havel, Mirza Arfan Yawer & Vladimir Sindelar
Bambusuril macrocycles allow qualitative and quantitative sensing of anion mixtures in water using 1H NMR spectroscopy.

Acyclic cucurbit[n]uril-type molecular containers: influence of glycoluril oligomer length on their function as solubilizing agents

Laura Gilberg, Ben Zhang, Peter Y. Zavalij, Vladimir Sindelar & Lyle Isaacs
A series of glycoluril molecular clips and acyclic CB[n]-type receptors are tested as solubilizing agents for insoluble drugs.

Supramolecular Storage and Controlled Photorelease of an Oxidizing Agent using a Bambusuril Macrocycle

Vladimir Sindelar, Edoardo Torti, Václav Havel, Mirza A. Yawer, Lucie Ludvíková, Michal Babiak & Petr Klán
Abstract The oxidizing ability of peroxodisulfate upon complexation inside the Bambusuril macrocycle cavity is inhibited. This dianionic agent can be released on demand from its stable 1:1 complex ...

Supramolecular binding and release of sulfide and hydrosulfide anions in water

Vladimir Sindelar & Julián Vázquez Gonzálvez
Bambusuril macrocycles bind and release sulfide and hydrosulfide anions in water.

Chiral hemicucurbit[8]uril as an anion receptor: selectivity to size, shape and charge distribution

Sandra Kaabel, Jasper Adamson, Filip Topić, Anniina Kiesilä, Elina Kalenius, Mario Öeren, Mart Reimund, Elena Prigorchenko, Aivar Lookene, Hans J. Reich, Kari Rissanen & Riina Aav
Chiral (all-R)-cyclohexanohemicucurbit[8]uril binds anions in a 1 : 1 ratio in pure methanol like a molecular Pac-Man™ with remarkable selectivity based on the size, shape and charge distribution of the anion.

Cucurbit[7]uril inclusion complexation as a supramolecular strategy for color stabilization of anthocyanin model compounds

Barbara Held, Hao Tang, Palani Natarajan, Cassio Pacheco da Silva, Volnir de Oliveira Silva, Cornelia Bohne & Frank H. Quina
Complete stabilization of the color of a flavylium cation by the formation of a higher order (1 : 2) complex with cucurbit[7]uril.

Bambusuril as a One-Electron Donor for Photoinduced Electron Transfer to Methyl Viologen in Mixed Crystals

Vladimir Sindelar, Lucie Ludvíková, Michal Babiak, Petr Klán, Dominik Heger, Tomas Fiala, Jan Švec, Tomáš Slanina, L’ubica Vetráková, Marek Nečas & Petr Kulhánek
Methyl viologen hexafluorophosphate (MV2+·2PF6–) and dodecamethylbambus[6]uril (BU6) form crystals in which the layers of viologen dications alternate with those of a 1:2 supramolecular complex of BU6 and PF6–. This arrangement allows for a one-electron reduction of MV2+ ions upon UV irradiation to form MV+• radical cations within the crystal structure with half-lives of several hours in air. The mechanism of this photoinduced electron transfer in the solid state and the origin of the long-lived charge-separated...

On the Nature of Guest Complexation in Water: Triggered Wetting–Water-Mediated Binding

Paolo Suating, Nicholas Ernst, Busayo Alagbe, Hannah Skinner, Joel Mague, Henry Ashbaugh & Bruce C. Gibb
TEEtOA vs. TEMOA – SAMPL8 dataset

Bis-urea macrocycles with a deep cavity

Guobao Huang, Kari Rissanen, Wei Jiang, Zhenfeng He, Chen-Xi Cai, Fangfang Pan & Dingqiao Yang
Two bis-urea macrocycles with a deep cavity demonstrate an enzyme-like binding, and the influence of dipole alignments on molecular recognition.

Hypervalent Iodine Based Reversible Covalent Bond in Rotaxane Synthesis

Vladimir Sindelar, Václav Havel, Marek Nečas, Markéta Kandrnálová & Zoran Kokan
The interlocked bambusuril: Reactive hypervalent iodine species possessing dynamic covalent bonds are utilized in a constitutive sense for the near quantitative synthesis of rotaxanes via the stabili...

Proximal charge effects on guest binding to a non-polar pocket

Paolo Suating, Thong , Nicholas Ernst, Yang Wang, Jacobs Jordan, Corinne L. D. Gibb, Henry Ashbaugh & Bruce Gibb
Science still does not have the ability to accurately predict changes in ligand affinity induced by proximal charged groups.

Modulation of Bambusuril Anion Affinity in Water

Vaclav Havel, Michal Babiak & Vladimir Sindelar
Abstract Neutral and negatively charged anion receptors functioning in pure water are rare in supramolecular chemistry. Moreover, studies on adjusting the affinity of such receptors toward anions i...

Cyclodextrin-assisted modulation of the photophysical properties and acidity constant of pyrene-armed calix[4]arene

Jyotirmayee Mohanty, V. S. Kalyani & D. D. Malkhede
The supramolecular pKa shift and modulation in the monomer and excimer emission behaviour of pyrene-armed calixarene with cyclodextrins find applications in ratiometric sensing.

pH-responsive molecular assemblies of pyridylbutadiene derivative with cucurbit[7]uril

Raman Khurana, Jyotirmayee Mohanty, Anuji K. Vasu & Sriram Kanvah
pH-responsive emission behavior of supramolecular complexes between pyridylbutadiene with CB7 and formation of molecular assemblies is described.

Determination of the kinetics underlying the pKa shift for the 2-aminoanthracenium cation binding with cucurbit[7]uril

Cornelia Bohne & Suma S. Thomas
The binding dynamics of the 2-aminoanthracenium cation (AH+) and 2-aminoanthracene (A) with cucurbit[7]uril (CB[7]) was studied using stopped-flow experiments. The kinetics was followed by measuring the fluorescence changes over time for AH+ and A, which emit at different wavelengths. The studies at various pH values showed different mechanisms for the formation of the AH+@CB[7] complex, with this complex formed either by the binding of AH+ or by the initial binding of A followed by protonation....

Anion Binding Inside a Bambus[6]uril Macrocycle in Chloroform

Vaclav Havel & Vladimir Sindelar
Abstract Bambus[6]urils are a class of neutral anion receptors with outstanding binding properties in various solvents. The host–guest associations of bambusurils in aqueous environments have been ...

The Cucurbit[n]uril Family:  Prime Components for Self-Sorting Systems

Simin Liu, Christian Ruspic, Pritam Mukhopadhyay, Sriparna Chakrabarti, Peter Y. Zavalij & Lyle Isaacs
We determined the values of Ka for a wide range of host−guest complexes of cucurbit[n]uril (CB[n]), where n = 6−8, using 1H NMR competition experiments referenced to absolute binding constants measured by UV/vis titration. We find that the larger homologuesCB[7] and CB[8]individually maintain the size, shape, and functional group selectivity that typifies the recognition behavior of CB[6]. The cavity of CB[7] is found to effectively host trimethylsilyl groups. Remarkably, the values of Ka for the...

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