4 Works

Data from: Mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide

Najla Al-Sweel, Vandana Raghavan, Abhishek Dutta, V. P. Ajith, Luigi Di Vietro, Nabila Khondakar, Carol M. Manhart, Jennifer Surtees, K. T. Nishant, Eric Alani & Jennifer A. Surtees
Mlh1-Mlh3 is an endonuclease hypothesized to act in meiosis to resolve double Holliday junctions into crossovers. It also plays a minor role in eukaryotic DNA mismatch repair (MMR). To understand how Mlh1-Mlh3 functions in both meiosis and MMR, we analyzed in baker's yeast 60 new mlh3 alleles. Five alleles specifically disrupted MMR, whereas one (mlh3-32) specifically disrupted meiotic crossing over. Mlh1-mlh3 representatives for each class were purified and characterized. Both Mlh1-mlh3-32 (MMR+, crossover-) and Mlh1-mlh3-45...

Data from: Enzyme architecture: modeling the operation of a hydrophobic clamp in catalysis by triosephosphate isomerase

Yashraj S. Kulkarni, Qinghua Liao, Dušan Petrovic, Dennis M. Krüger, Birgit Strodel, Tina L. Amyes, John P. Richard & Shina Caroline Lynn Kamerlin
Triosephosphate isomerase (TIM) is a proficient catalyst of the reversible isomerization of dihydroxyacetone phosphate (DHAP) to d-glyceraldehyde phosphate (GAP), via general base catalysis by E165. Historically, this enzyme has been an extremely important model system for understanding the fundamentals of biological catalysis. TIM is activated through an energetically demanding conformational change, which helps position the side chains of two key hydrophobic residues (I170 and L230), over the carboxylate side chain of E165. This is critical...

Data from: The evolution of hominoid cranial diversity: a quantitative genetic approach

Lauren Schroeder & Noreen Von Cramon-Taubadel
Hominoid cranial evolution is characterized by substantial phenotypic diversity, yet the cause of this variability has rarely been explored. Quantitative genetic techniques for investigating evolutionary processes underlying morphological divergence are dependent on the availability of good ancestral models, a problem in hominoids where the fossil record is fragmentary and poorly understood. Here, we use a maximum likelihood approach based on a Brownian motion model of evolutionary change to estimate nested hypothetical ancestral forms from 15...

Data from: Feeding capability in the extinct giant Siamogale melilutra and comparative mandibular biomechanics of living Lutrinae

Z. Jack Tseng, Denise F. Su, Xiaoming Wang, Stuart C. White & Xueping Ji
At 50 kg in estimated weight, the extinct Siamogale melilutra is larger than all living otters, and ranks among the largest fossil otters. The biomechanical capability of S. melilutra jaws as related to their large size is unknown but crucial to reconstructing the species’ potentially unique ecological niche. Here we compare the mandibular biomechanics of S. melilutra using engineering-based performance measures against ten extant otter biomechanical models. Despite a wide range of feeding preferences from...

Registration Year

  • 2017

Resource Types

  • Dataset


  • University at Buffalo, State University of New York
  • State University of New York
  • Forschungszentrum Jülich
  • Yunnan Archaeology
  • University of Toronto
  • University of Cape Town
  • American Museum of Natural History
  • Queens College, CUNY
  • University of California Los Angeles
  • Uppsala University