Additional file 10: Table S6. Allele frequencies of Q9311B and WSSM in 1946 accessions from 3 K-RG.

Additional file 13: Table S8. The genotypic and phenotypic matrix of the population in ICIMapping format.

This dataset contains measures of loneliness, anxiety, and depression from a cross-sectional study conducted during the COVID-19 pandemic.

Additional file 2: Table S1. Coverage uniformity across gene body and gene number detected by SHERRY2 when testing different conditions on bulk RNA. (data values of Additional file 1: Fig. S1).

Additional file 2: Table S1. Coverage uniformity across gene body and gene number detected by SHERRY2 when testing different conditions on bulk RNA. (data values of Additional file 1: Fig. S1).

Supplementary Material 1

Supplementary Material 3

Supplementary Material 5

Additional file 10: Table S7. Mutation site information screened by whole genome sequencing.

Additional file 5: Table S2. Primers for amplifying fragments of the target site.

Additional file 9: Table S6. Mutation site information obtained by targeted sequencing.

Additional file 9: Table S2. Differently expressed protein applying TMT10plex.

Additional file 6 Table S1. Browse interactions in tabular form.

Additional file 7 Table S2. Gene Ontology term enrichment analysis of the MAPK8IP2 gene and its partner genes.

Additional file 2: Table S1. Correlation analysis of ARPC1B with PN and MES marker genes (Correlation). Table S2. Mass spectrometry result of proteins related with ARPC1B. Table S3. The correlation between the ARPC1B expression and drug sensitivity assessed by Spearman algorithm (correlation).

Additional file 1.

Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication. Old C57BL/6J mice were injected with the silencing lentivirus of MIR99AHG and subjected to microCT analysis and immunohistochemistry on osteogenic cells. The osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) with or without transfection was determined by alkaline phosphatase (ALP) and Alizarin Red S staining. Total N(6)-methyladenosine (m6A) on the...

Additional file 4: Video 1. [head falling on one side, body quiescent tremor and rhythmical and vertical head movements]. Video 2. [a tendency to turn in the same direction when lifted by the tail]. Video 3. [stagnation and turning backward in the same direction in unfamiliar environments, with the hind limbs open and stride length altered]. Video 4. [mice circling after infection].

Additional file 1. The list of differentially expressed genes

Additional file 9. Supplementary RNA sequencing results.

Obesity is a chronic metabolic disorder characterized by the accumulation of excess fat in the body. Preventing and controlling obesity by inhibiting the adipogenic differentiation of mesenchymal stem cells (MSCs) and thereby avoiding the increase of white adipose tissue is safe and effective. Recent studies have demonstrated that Sprouty proteins (SPRYs) are involved in cell differentiation and related diseases. However, the role and mechanism of SPRY4 in MSC adipogenic differentiation remain to be explored. Here,...

A gastrointestinal stromal tumor (GIST) is mostly driven by the auto-activated, mutant KIT receptor tyrosine kinase gene or by the platelet-derived growth factor receptor alpha. Inhibition of KIT-signaling is the primary molecular target therapy for GIST, which is performed by the drug imatinib clinically. However, more than half of advanced or metastatic GIST develop secondary resistance to imatinib within 2 years after initiation of treatment, and the mechanism of acquired imatinib-resistant in GIST remains unclear....

A gastrointestinal stromal tumor (GIST) is mostly driven by the auto-activated, mutant KIT receptor tyrosine kinase gene or by the platelet-derived growth factor receptor alpha. Inhibition of KIT-signaling is the primary molecular target therapy for GIST, which is performed by the drug imatinib clinically. However, more than half of advanced or metastatic GIST develop secondary resistance to imatinib within 2 years after initiation of treatment, and the mechanism of acquired imatinib-resistant in GIST remains unclear....

In this study, we presented a case series to highlight the chromosomal microarray (CMA) in identifying chromosomal abnormalities which is undetectable by conventional karyotyping or known abnormal chromosomes without clear diagnosis. Extensive studies showed that CMA was gradually accepted as a prenatal invasive testing during pregnancy. The aim of this study was to evaluate the diagnostic effect of CMA for foetuses with abnormal chromosomes unrecognised by conventional karyotyping. Pregnant women who need prenatal diagnosis with...