297 Works

Additional file 29 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma

Yexin Tong, Mingjun Sun, Lingli Chen, Yunzhi Wang, Yan Li, Lingling Li, Xuan Zhang, Yumeng Cai, Jingbo Qie, Yanrui Pang, Ziyan Xu, Jiangyan Zhao, Xiaolei Zhang, Yang Liu, Sha Tian, Zhaoyu Qin, Jinwen Feng, Fan Zhang, Jiajun Zhu, Yifan Xu, Wenhui Lou, Yuan Ji, Jianyuan Zhao, Fuchu He, Yingyong Hou … & Chen Ding
Additional file 29: Table S7. Characterization of Immune Infiltration in PDAC. Table S7A Matrix of xCell signatures significantly altered in 5 immune subgroups. Table S7B Matrix describing the expression of proteins in 5 immune subgroups. Table S7C Matrix of GSVA scores of pathways significantly altered in 5 immune subgroups, transcriptome level. Table S7D Matrix of amplification/deletion events of genes in 5 immune subgroups. Table S7E Matrix describing the expression of proteins involved in TCA cycle.

Ultrasensitive lateral-flow assays via plasmonically active antibody-conjugated fluorescent nanoparticles

Srikanth Singamaneni, Rohit Gupta, Prashant Gupta, Sean Wang, Artem Melnykov, Qisheng Jiang, Anushree Seth, Zheyu Wang, Jeremiah J. Morrissey, Ige George, Sumanth Gandra, Pratik Sinha, Gregory A. Storch, Bijal A. Parikh & Guy M. Genin
Lateral flow assays (LFAs) are rapid and inexpensive, yet they are nearly 1,000-fold less sensitive than laboratory-based tests. Here, we show that plasmonically active antibody-conjugated fluorescent gold nanorods can make conventional LFAs ultrasensitive. With sample-to-answer times within 20 min, plasmonically enhanced LFAs read out via a standard benchtop fluorescence scanner attained about 30-fold improvements in dynamic range and in detection limits over four-hour-long gold-standard enzyme-linked immunosorbent assays, and achieved 95% clinical sensitivity and 100% specificity...

Additional file 12 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Additional file 12: Table S5. Taxa associated with TMA metabolism using LEfSe analysis.

Knockdown of lncRNA PCAT6 suppresses the growth of non-small cell lung cancer cells by inhibiting macrophages M2 polarization via miR-326/KLF1 axis

Yun Chen, Chaojin Hong, Jing Qu, Junjun Chen & Zhiquan Qin
Non-small cell lung cancer (NSCLC) is the most common malignant tumor of lung, which seriously threatens the life of people. It has been reported that lncRNA prostate cancer-associated transcript 6 (PCAT6) could facilitate the metastasis of NSCLC cells. However, whether lncRNA PCAT6 in NSCLC cells could affect the tumor microenvironment (TME) remains unclear. In the present study, the level of PCAT6 in NSCLC cells was detected using RT-qPCR. The effects of PCAT6 knockdown on the...

Semi-brittle deformation of talc at the base of the seismogenic zone

Charis Horn & Philip Skemer

Quantification of carbonates, oxychlorines, and chlorine generated by heterogeneous electrochemistry induced by Martian dust activity

Alain Wang, Neil Sturchio, Jen Houghton, Andrew Jackson, Kevin Olsen, Chuck Yan & Quincy Qu

Long non-coding RNA TRPM2 antisense RNA as a potential therapeutic target promotes tumorigenesis and metastasis in esophageal cancer

Wei Wang, Yukai Dai, Xin Yang & Xinming Xiong
Esophageal cancer (EC) is one type of aggressive gastrointestinal cancers. The treatment of EC is challenging. Effective therapeutic targets require development. Long non-coding RNA TRPM2 antisense RNA (LncRNA TRPM2-AS) is considering a novel biomarker and therapeutic target for various types of cancer. However, the role of lncRNA TRPM2-AS in EC remains unknown. This study aimed to illustrate effects of LncRNA TRPM2-AS on EC growth and metastasis and potential underlying molecular mechanisms. LncRNA TRPM2-AS expression was...

Identification of differentially expressed miRNAs and their target genes in response to brassinolide treatment on flowering of tree peony (Paeonia ostii)

Lin Zhang, Chengwei Song, Dalong Guo, Lili Guo, Xiaogai Hou & Huafang Wang
Tree peony is a famous flower plant in China, but the short and concentrated flowering period limits its ornamental value and economic value. Brassinolide (BR) plays an important role in plant growth and development including flowering. There have been a large number of reports on the molecular aspects of the flowering process, but the genetic mechanism that was responsible for miRNA-guided regulation of tree peony is almost unclear. In this study, the leaves of tree...

Dewlap color variation in Anolis sagrei is maintained among habitats within islands of the West Indies

Raphaël Scherrer, Colin M Donihue, R Graham Reynolds, Jonathan B Losos & Anthony J Geneva
Animal signals evolve in an ecological context. Locally adapting animal sexual signals can be especially important for initiating or reinforcing reproductive isolation during the early stages of speciation. Previous studies have demonstrated that dewlap color in Anolis lizards can be highly variable between populations in relation to both biotic and abiotic adaptive drivers at relatively large geographical scales. Here, we investigated differentiation of dewlap coloration among habitat types at a small spatial scale, within multiple...

Episodic continental extension in eastern Gondwana during the mid-late mesozoic: insights from geochronology and geochemistry of mafic rocks in the Tethyan Himalaya

Kai Yang, Jingen Dai, Jie Shen & Xiaolong Jia
Mesozoic extension and rifting processes of the Gondwana continent are critical for understanding the opening and formation of the Indian Ocean. Here, we report petrological, geochemical, zircon U–Pb age, and Lu–Hf isotopic data of mafic dikes in the central Tethyan Himalaya to reveal the timing and mechanism of the eastern Gondwana rifting. These mafic rocks exhibit two groups in terms of TiO2 and MgO contents (Group I with TiO2 < 2.0 wt.%, whereas Group II...

SPRY4 promotes adipogenic differentiation of human mesenchymal stem cells through the MEK–ERK1/2 signaling pathway

Na Li, Yunfei Chen, Haiyan Wang, Jing Li & Robert Chunhua Zhao
Obesity is a chronic metabolic disorder characterized by the accumulation of excess fat in the body. Preventing and controlling obesity by inhibiting the adipogenic differentiation of mesenchymal stem cells (MSCs) and thereby avoiding the increase of white adipose tissue is safe and effective. Recent studies have demonstrated that Sprouty proteins (SPRYs) are involved in cell differentiation and related diseases. However, the role and mechanism of SPRY4 in MSC adipogenic differentiation remain to be explored. Here,...

High expression of HOXA4 in patients with glioma indicates unfavorable clinical outcomes

Zhenghong Yu, Zhendong Liu, Xiaoyu Lian, Xingbo Cheng, Binfeng Liu, Bo Zhang, Hongbo Wang, Jialin Wang, Ang Li, Zhishuai Ren, Bo Pang, Rongjun Qian & Yanzheng Gao
HOXA4 is a novel oncogene that has been observed in many kinds of tumors, but its role during glioma carcinogenesis and its clinical significance in diagnosing and prognosis human glioma remains unknown. In the present study, the Chinese Glioma Atlas (CGGA)-RNA sequencing database, CGGA microarray, and The Cancer Genome Atlas (TCGA)-RNA seq data from 1674 glioma patients were obtained from online databases and analyzed using quantitative reverse transcription-polymerase chain reaction (RT-qPCR) to detect changes in...

Testing Biased Randomization Assumptions and Quantifying Imperfect Matching and Residual Confounding in Matched Observational Studies

Kan Chen, Siyu Heng, Qi Long & Bo Zhang
One central goal of design of observational studies is to embed nonexperimental data into an approximate randomized controlled trial using statistical matching. Despite empirical researchers’ best intention and effort to create high-quality matched samples, residual imbalance due to observed covariates not being well matched often persists. Although statistical tests have been developed to test the randomization assumption and its implications, few provide a means to quantify the level of residual confounding due to observed covariates...

sj-xlsx-2-tct-10.1177_15330338221124658 - Supplemental material for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells

Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Supplemental material, sj-xlsx-2-tct-10.1177_15330338221124658 for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells by Mike Y. Chen, Jing Li, Nianli Zhang and Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia, Yujun Wang in Technology in Cancer Research & Treatment

sj-xlsx-3-tct-10.1177_15330338221124658 - Supplemental material for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells

Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Supplemental material, sj-xlsx-3-tct-10.1177_15330338221124658 for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells by Mike Y. Chen, Jing Li, Nianli Zhang and Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia, Yujun Wang in Technology in Cancer Research & Treatment

Application of virus-induced gene silencing in Pogostemon cablin advances our understanding of patchoulol and sesquiterpene metabolism

Shibin Chen, Xiaobing Wang, Hai Zheng & Likai Chen
In plant species, virus-induced gene silencing (VIGS) effectively enables the transient knock down of target genes for functional analysis. To overcome the bottleneck preventing the functional genomics and biological engineering of Pogostemon cablin (Blanco) Benth. an important medicinal and industrial plant with high-value natural products, the VIGS system was established to enable the fast and efficient functional characterisation of candidate genes. In our study, the effectiveness of phytoene desaturase (PDS) gene silencing by VIGS was...

Additional file 4 of Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development

Xueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang & Junmei Kang
Additional file 4: Table S2. List of 2,443 leaf-specific genes.

Additional file 5 of Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development

Xueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang & Junmei Kang
Additional file 5: Table S3. List of 2,061 up-regulated genes (‘sativa’ Vs ‘falcata’).

Additional file 2 of Genome-wide identification of key enzyme-encoding genes and the catalytic roles of two 2-oxoglutarate-dependent dioxygenase involved in flavonoid biosynthesis in Cannabis sativa L.

Xuewen Zhu, Yaolei Mi, Xiangxiao Meng, Yiming Zhang, Weiqiang Chen, Xue Cao, Huihua Wan, Wei Yang, Jun Li, Sifan Wang, Zhichao Xu, Atia Tul Wahab, Shilin Chen & Wei Sun
Additional file 2: Table S2. Quantitative primers of the selected enzyme-encoding genes of flavonoid metabolic pathway in C. sativa.

Improving winter wheat yield estimation under complex irrigation conditions through coupling APSIM crop growth model and the machine learning approach

Quandi Niu, Jianxi Huang, Xuecao Li, Hai Huang, Haixiang Guan, Wei Wang, Wei Su, Li Li, Shuangxi Miao & Dongqin Yin
The annual dynamics of winter wheat yield in Henan, China from 2018 to 2021 are provided, with the resolution of 20m and GeoTiff format.

Data for: Evolutionary interactions between thermal ecology and sexual selection

Noah Leith, Kasey Fowler-Finn & Michael Moore
Thermal ecology and mate competition are both pervasive features of ecological adaptation. A surge of recent work has uncovered the diversity of ways in which temperature affects mating interactions and sexual selection. However, the potential for thermal biology and reproductive ecology to evolve together as organisms adapt to their thermal environment has been underappreciated. Here, we develop a series of hypotheses regarding (1) not only how thermal ecology affects mating system dynamics, but also how...

Numerical simulation of a cyclone separator to recycle the active components of waste lithium batteries

Xiaoxian Pang, Chengyun Wang, Wei Yang, Haosen Fan, Shi Zhong, Wenzhi Zheng, Hanbo Zou & Shengzhou Chen
In this paper, cyclone separator is proposed for the first time to separate particles according to density, and it is applied to the recovery of lithium iron phosphate (LFP) from spent lithium battery materials for the first time. The effect of the flow field on the motion of injected particles in a cyclone separator is studied by means of computational fluid dynamics (CFD). It is found that there is a classification phenomenon caused by the...

Numerical simulation of a cyclone separator to recycle the active components of waste lithium batteries

Xiaoxian Pang, Chengyun Wang, Wei Yang, Haosen Fan, Shi Zhong, Wenzhi Zheng, Hanbo Zou & Shengzhou Chen
In this paper, cyclone separator is proposed for the first time to separate particles according to density, and it is applied to the recovery of lithium iron phosphate (LFP) from spent lithium battery materials for the first time. The effect of the flow field on the motion of injected particles in a cyclone separator is studied by means of computational fluid dynamics (CFD). It is found that there is a classification phenomenon caused by the...

Data from: Phylogenomics and historical biogeography of West Indian Rock Iguanas (genus Cyclura)

Robert Graham Reynolds & Aryeh Miller
The genus Cyclura includes nine extant species and six subspecies of West Indian Rock Iguanas and is one of the most imperiled genera of squamate reptiles globally. An understanding of species diversity, evolutionary relationships, diversification, and historical biogeography in this group is crucial for implementing sound long-term conservation strategies. We collected DNA samples from 1–10 individuals per taxon from all Cyclura taxa (n = 70 ingroup individuals), focusing where possible on incorporating individuals from different...

Long non-coding RNA LINRIS is upregulated in non-small cell lung cancer and its silencing inhibits cell proliferation by suppressing microRNA-10a maturation

Yajie Zhu, Ke Ma, Yingxue Ye, Jianning Tang & Jiang Zhu
Long noncoding RNA LINRIS (LINC00920) is known to participate in colorectal cancer. This study aimed to explore the role of LINRIS in non-small cell lung cancer (NSCLC). NSCLC and adjacent non-tumor tissues were collected from 62 NSCLC patients. LINRIS expression was detected using real-time quantitative PCR (RT-qPCRs). The 62 NSCLC patients were monitored every month for 5 years to evaluate the role of LINRIS in predicting the prognosis of NSCLC. The effects of LINRIS silencing...

Registration Year

  • 2022
    297

Resource Types

  • Dataset
    297

Affiliations

  • Washington University in St. Louis
    297
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    195
  • Shanghai Jiao Tong University
    178
  • Sichuan University
    174
  • Zhejiang University
    173
  • Fudan University
    173
  • Sun Yat-sen University
    161
  • Capital Medical University
    146
  • Xuzhou Medical College
    133
  • University of Chinese Academy of Sciences
    125