Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a global scale, but the environmental influence on the plasticity of genetic networks has not been examined systematically. To assess environmental rewiring of genetic networks, we examined 14 diverse conditions and scored 30,000 functionally representative yeast gene pairs for dynamic, differential interactions. Different conditions revealed novel...

Additional file 2: Table S1. Assembly statistics for the re-assembly of the genomes from Arastehfar et al. [20]. Table S2. List of rearrangements when compared to the C. glabrata sanger reference strain. Table S3. Summary of the results of the gene annotation for the 21 C. glabrata strains. Table S4. Complete list of orthogroups as determined by orthofinder. Table S5. List of chromosome substitutions during assembly. Table S6. List of predicted adhesins for the 21...

DNA double-strand breaks are repaired by end-joining or homologous recombination. A key-committing step of recombination is DNA end resection. In resection, phosphorylated CtIP first promotes the endonuclease of the MRE11-RAD50-NBS1 (MRN) complex. Subsequently, CtIP also stimulates the BLM-DNA2 helicase-nuclease, coordinating thus both short and long-range resection. The structure of CtIP differs from its orthologues in yeast, as it contains a large internal region. Here we conducted a domain analysis of the internal region of CtIP...

Additional file 2: Table S1. Assembly statistics for the re-assembly of the genomes from Arastehfar et al. [20]. Table S2. List of rearrangements when compared to the C. glabrata sanger reference strain. Table S3. Summary of the results of the gene annotation for the 21 C. glabrata strains. Table S4. Complete list of orthogroups as determined by orthofinder. Table S5. List of chromosome substitutions during assembly. Table S6. List of predicted adhesins for the 21...