108 Works

Data from: The multivariate association between genomewide DNA methylation and climate across the range of Arabidopsis thaliana

Thomas E. Keller, Jesse R. Lasky & Soojin V. Yi
Epigenetic changes can occur due to extracellular environmental conditions. Consequently, epigenetic mechanisms can play an intermediate role to translate environmental signals to intracellular changes. Such a role might be particularly important in plants, which often show strong local adaptation and have the potential for heritable epigenetic states. However, little is currently known about the role of epigenetic variation in the ecological mechanisms of adaptation. Here, we used multivariate redundancy analyses to examine genomewide associations between...

Data from: Genetics of a de novo origin of undifferentiated multicellularity

Matthew D. Herron, William C. Ratcliff, Jacob Boswell & Frank Rosenzweig
The evolution of multicellularity was a major transition in evolution and set the stage for unprecedented increases in complexity, especially in land plants and animals. Here we explore the genetics underlying a de novo origin of multicellularity in a microbial evolution experiment carried out on the green alga Chlamydomonas reinhardtii. We show that large-scale changes in gene expression underlie the transition to a multicellular life cycle. Among these, changes to genes involved in cell cycle...

Data from: Courting disaster: how diversification rate affects fitness under risk

William C. Ratcliff, Peter Hawthorne & Eric Libby
Life is full of risk. To deal with this uncertainty, many organisms have evolved bet-hedging strategies that spread risk through phenotypic diversification. These rates of diversification can vary by orders of magnitude in different species. Here we examine how key characteristics of risk and organismal ecology affect the fitness consequences of variation in diversification rate. We find that rapid diversification is strongly favored when the risk faced has a wide spatial extent, with a single...

Data from: Repeatability and contingency in the evolution of a key innovation in phage lambda

Justin R. Meyer, Devin T. Dobias, Joshua S. Weitz, Jeffrey E. Barrick, Ryan T. Quick & Richard E. Lenski
The processes responsible for the evolution of key innovations, whereby lineages acquire qualitatively new functions that expand their ecological opportunities, remain poorly understood. We examined how a virus, bacteriophage λ, evolved to infect its host, Escherichia coli, through a novel pathway. Natural selection promoted the fixation of mutations in the virus’s host-recognition protein, J, that improved fitness on the original receptor, LamB, and set the stage for other mutations that allowed infection through a new...

Incorporating New Technologies in EEIO Models - Case Study Input Data

Cindy Azuero Pedraza, Valerie Thomas & Wesley Ingwersen

Dataset for \"Propulsion cost changes of ultra-lightweight manual wheelchairs after one year of simulated use\"

Jacob Misch & Stephen Sprigle

Clinical, technical, and implementation characteristics of real-world health applications using FHIR

Ashley Griffin, Lu He, Anthony Sunjaya, Andrew King, Zubin Khan, Martin Nwadiugwu, Brian Douthit, Vignesh Subbian, Viet Nguyen, Mark Braunstein, Charles Jaffe & Titus Schleyer
Fast Healthcare Interoperability Resources (FHIR) has received vast support globally, with a growing number of use cases implemented throughout various healthcare settings. To assess the use of real-world FHIR applications (apps) implemented in practice, we distributed an electronic survey to FHIR developers and implementers. The data includes characteristics of 112 FHIR apps, including health domain, target audience, terminologies, FHIR specifications, implementation details, and types of organizations developing with FHIR. This repository includes the survey dataset...

Soil microbes respond to four-year warming and precipitation alteration

Qi Qi, Jianshu Zhao, Renmao Tian, Yufei Zeng, Changyi Xie, Qun Gao, Tianjiao Dai, Hao Wang, Jin-Sheng He, Konstantinos Konstantinidis, Yunfeng Yang, Jizhong Zhou & Xue Guo
The alpine grasslands of the Tibetan Plateau store 23.2 Pg soil organic carbon (SOC), which becomes susceptible to microbial degradation with climate warming. However, accurate prediction of how the soil carbon (C) stock changes under future climate warming is hampered by our limited understanding of below-ground complex microbial communities. Here, we show that 4 years of warming strongly stimulated methane (CH4) uptake by 93.8% and aerobic respiration (CO2) by % in the soils of alpine...

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