4 Works

Fine particulate matter and neuroanatomic risk for Alzheimer’s disease in older women

Diana Younan, Xinhui Wang, Ramon Casanova, Ryan Barnard, Sarah Gaussoin, Santiago Saldana, Andrew Petkus, Daniel Beavers, Susan Resnick, JoAnn Manson, Marc Serre, William Vizuete, Victor Henderson, Bonnie Sachs, Joel Salinas, Margaret Gatz, Mark Espeland, Helena Chui, Sally Shumaker, Stephen Rapp & Jiu-Chiuan Chen
Objective: To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer’s disease (AD) using a community-dwelling cohort of women (aged 71-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). Methods: AD pattern similarity (AD-PS) scores, developed by supervised machine learning and validated with MRI data from the AD Neuroimaging Initiative, was used to capture high-dimensional gray matter atrophy in brain areas...

Interleukin-6 (IL-6) activates the NOTCH1 signaling pathway through E-proteins in endometriotic lesions

Yong Song, RenWei Su, Niraj R. Joshi, Tae Hoon Kim, Bruce A Lessey, Jae-Wook Jeong & Asgerally T Fazleabas
Context: NOTCH signaling is activated in endometriotic lesions but the exact mechanisms remains unclear. Interleukin-6 (IL-6), which is increased in the peritoneal fluid of women with endometriosis, induces NOTCH1 through E-proteins including E2A and HEB in cancer development. Objective: To study the role of E-proteins in inducing NOTCH1 expression under the regulation of IL-6 in endometriosis. Setting and Design: The expression of E2A, HEB and NOTCH1 was first investigated in endometrium of women with endometriosis...

Data from: Validation of serum neurofilaments as prognostic & potential pharmacodynamic biomarkers for ALS

Michael Benatar, Lanyu Zhang, Lily Wang, Volkan Granit, Jeffrey Statland, Richard Barohn, Andrea Swenson, John Ravitz, Carlayne Jackson, Ted Burns, Jaya Trivedi, Erik Pioro, James Caress, Jonathan Katz, Jacob McCauley, Rosa Rademakers, Andrea Malaspina, Lyle Ostrow & Joanne Wuu
Objective. Identify preferred neurofilament assays, and clinically validate serum NfL and pNfH as prognostic and potential pharmacodynamic biomarkers relevant to ALS therapy development. Methods. Prospective, multi-center, longitudinal observational study of patients with ALS (n=229), primary lateral sclerosis (PLS, n=20) and progressive muscular atrophy (PMA, n=11). Biological specimens were collected, processed and stored according to strict standard operating procedures (SOPs) 1. Neurofilament assays were performed in a blinded manner by independent contract research organizations (CROs). Results....

Efficient production of few-layer black phosphorus by liquid-phase exfoliation

Ghassane Tiouitchi, Mustapha Ait Ali, Abdelilah Benyoussef, Mohammed Hamedoun, Abdessadek Lachgar, Abdelkader Kara, Ahmed Ennaoui, Abdelfattah Mahmoud, Frederic Boschini, Hamid Oughaddou, Amine El Moutaouakil, Abdellah El Kenz & Omar Mounkachi
Phosphorene is a new 2D material that has recently attracted much attention owing to its fascinating electrical, optical, thermal, and chemical properties. Here, we report on high-quality exfoliation of black phosphorus nanosheets, with controllable size produced in large quantities by liquid phase exfoliation using N-methyl-2-pyrrolidone (NMP) as a solvent under ambient conditions. The as-synthesized few layers show a great potential for solar energy conversion based on the optical results shown in this work.

Registration Year

  • 2020
    4

Resource Types

  • Dataset
    4

Affiliations

  • Wake Forest University
    4
  • Massachusetts General Hospital
    1
  • University of Liège
    1
  • Stanford University
    1
  • Mohammed V University
    1
  • Southwestern Medical Center
    1
  • Johns Hopkins University
    1
  • University of North Carolina
    1
  • University of Virginia
    1
  • University of California, San Diego
    1