2 Works

Low circulating levels of miR-451a in girls with Polycystic Ovary Syndrome: different effects of randomized treatments

Lourdes Ibanez, Marta Diaz, Judit Bassols, Abel Lopez-Bermejo & Francis De Zegher
Context: Polycystic ovary syndrome (PCOS) is a prevalent disorder in adolescent girls, purportedly driven by hepato-visceral fat excess, and often followed by subfertility and type 2 diabetes. Objective:we studied the baseline miRNA profile of girls with PCOS, and the effects of a randomized treatment with an oral contraceptive (OC) or with spironolactone-pioglitazone-metformin (SPIOMET, aiming at loss of hepato-visceral fat excess) for 1 year. Design & Patients:The miRNA profile was assessed by RNA sequencingin girls with...

Gut microbiota in non-obese adolescent girls with polycystic ovary syndrome: effects of randomized treatments

Lourdes Ibáñez, Cristina Garcia-Beltran, Rita Malpique, Belen Carbonetto, Pedro González-Torres, Desirée Henares, Pedro Brotons, Carmen Muñoz-Almagro, Abel López-Bermejo & Francis De Zegher
Context: Women and obese adolescent girls with polycystic ovary syndrome (PCOS) have altered gut microbiota. Objective: To study the gut microbiota composition of non-obese adolescent girls with PCOS and the effects of randomized pharmacological treatments. Design: Randomized, open-label, single-center controlled trial. Settings: Endocrinology Department, University Hospital. Participants: 30 girls with PCOS [age 15.8 years; body mass index (BMI) 25 kg/ m2] and 31 controls [age 15.9 years; BMI 22 kg/ m2]. Intervention: PCOS girls were...

Registration Year

  • 2020

Resource Types

  • Dataset


  • Hospital Sant Joan de Déu Barcelona
  • Institut d'Investigació Biomèdica de Girona
  • KU Leuven
  • S.L. Raheja Hospital