2 Works

Data from: Force encoding in muscle spindles during stretch of passive muscle

Kyle P. Blum, Boris Lamotte D’Incamps, Daniel Zytnicki & Lena H. Ting
Muscle spindle proprioceptive receptors play a primary role in encoding the effects of external mechanical perturbations to the body. During externally-imposed stretches of passive, i.e. electrically-quiescent, muscles, the instantaneous firing rates (IFRs) of muscle spindles are associated with characteristics of stretch such as length and velocity. However, even in passive muscle, there are history-dependent transients of muscle spindle firing that are not uniquely related to muscle length and velocity, nor reproduced by current muscle spindle...

Data from: PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

Arman Javadi, Ravi K. Deevi, Emma Evergren, Elodie Blondel-Tepaz, George S. Baillie, Mark G.H. Scott, Frederick Charles Campbell & Mark GH Scott
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β-Arrestin1. Because β-Arrestin1 binds and suppresses the Cdc42 GTPase-activating protein ARHGAP21, we hypothesize that PTEN controls Cdc42-dependent morphogenic processes through a β-Arrestin1-ARHGAP21 complex. Here we show that PTEN knockdown (KD) impairs β-Arrestin1 membrane localization, β-Arrestin1-ARHGAP21 interactions, Cdc42 activation, mitotic spindle orientation and 3D glandular morphogenesis....

Registration Year

  • 2017
    2

Resource Types

  • Dataset
    2

Affiliations

  • Paris Descartes University
    2
  • Queen's University Belfast
    1
  • University of Glasgow
    1
  • Georgia Institute of Technology
    1
  • French National Centre for Scientific Research
    1
  • Emory University
    1
  • Institut Cochin
    1