57 Works

Data from: Association between probable postnatal depression and increased infant mortality and morbidity: findings from the DON population-based cohort study in rural Ghana

Benedict Weobong, Augustinus H. A. Ten Asbroek, Seyi Soremekun, Lu Gram, Seeba Amenga-Etego, Samuel Danso, Seth Owusu-Agyei, Martin Prince & Betty R. Kirkwood
Objectives: To assess the impact of probable depression in the immediate postnatal period on subsequent infant mortality and morbidity. Design: Cohort study nested within 4 weekly surveillance of all women of reproductive age to identify pregnancies and collect data on births and deaths. Setting: Rural/periurban communities within the Kintampo Health Research Centre study area of the Brong-Ahafo Region of Ghana. Participants: 16 560 mothers who had a live singleton birth reported between 24 March 2008...

Data from: The association between subjective memory complaint and objective cognitive function in older people with previous major depression

Chung-Shiang Chu, I-Wen Sun, Aysha Begum, Shen-Ing Liu, Ching-Jui Chang, Wei-Che Chiu, Chin-Hsin Chen, Hwang-Shen Tang, Chia-Li Yang, Ying-Chin Lin, Chih-Chiang Chiu & Robert Stewart
The goal of this study is to investigate associations between subjective memory complaint and objective cognitive performance in older people with previous major depression-a high-risk sample for cognitive impairment and later dementia. A cross-sectional study was carried out in people aged 60 or over with previous major depression but not fulfilling current major depression criteria according to DSM-IV-TR. People with dementia or Mini-Mental State Examination score less than 17 were excluded. Subjective memory complaint was...

Substrate utilisation profiles for saprotrophic fungi and moisture content data from soil sampled in an upland grassland experiment at Sourhope, Scotland, 2001 [NERC Soil Biodiversity Programme]

L.J. Deacon, E.J. Pryce-Miller, J.C. Frankland, B.W. Bainbridge, P.D. Moore, C.H. Robinson & N. Parekh
This set of data comprises substrate utilisation profiles for saprotrophic fungi (using the commercially available BIOLOG plate method) and moisture content data from soils sampled from experimental plots at Sourhope, Scotland. The data were collected in order to determine how the high species richness of decomposer (saprotrophic) fungi and their relative frequencies of occurrence influence the decomposition of organic matter. Data were collected during a project funded under the NERC Soil Biodiversity Programme, established in...

Data from: Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi C. Lam, Felix D. Weiss, Zoe Powis, Pim Suwannarat, Christopher J. Lelliot, Sally J. Dawson, Jacqueline K. White & Karen P. Steel
Adult-onset hearing loss is very common but we know little about the underlying molecular pathogenesis, impeding development of therapies. We took a genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly-generated mouse mutants using a sensitive electrophysiological test, the auditory brainstem response. We review here the findings from this screen. Thirty-eight unexpected genes associated with raised thresholds were detected from our unbiased sample of 1,211 genes tested,...

Intracellular sodium elevation reprograms cardiac metabolism: Metabolomics data

Dunja Aksentijevic, Anja Karlstaedt, Marina Basalay, Brett O'Brien, David Sanchez-Tatay, Seda Eminaga, Alpesh Thakker, Daniel Tennant, William Fuller, Thomas Eykyn, Heinrich Taegtmeyer & Michael Shattock
Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodeling occurs. We assessed whether acute (75μM ouabain 100nM blebbistatin) and chronic myocardial Naiload (PLM3SA mouse) are causally linked to metabolic remodeling and whether the hypertrophied failing heart shares a common Na-mediated metabolic ‘fingerprint’. Control (PLMWT), transgenic (PLM3SA), ouabain treated and hypertrophied Langendorff-perfused mouse hearts were studied by 23Na, 31P, 13C NMR followed by 1H NMR metabolomic profiling....

Traits data of exotic species in four tropical botanic gardens and adjacent natural forests

Decky Junaedi, Gurutzeta Guillera-Arroita, Peter Vesk, Michael McCarthy, Mark Burgman & Jane Catford
The establishment of new botanic gardens in tropical regions highlights a need for weed risk assessment tools suitable for tropical ecosystems. The relevance of plant traits for invasion into tropical rainforests has not been well studied. Working in and around four botanic gardens in Indonesia where 600 exotic species have been planted, we estimated the effect of four plant traits and time since species were introduced on: a) naturalization probability of exotic species; b) the...

Traits data of naturalized and non-naturalized alien species of four Indonesian Botanic Gardens

Decky Junaedi, Jane Catford, Mark Burgman, Michael McCarthy, Gurutzeta Guillera-Arroita & Peter Vesk
The establishment of new botanic gardens in tropical regions highlights a need for weed risk assessment tools suitable for tropical ecosystems. The relevance of plant traits for invasion into tropical rainforests has not been well studied. Working in and around four botanic gardens in Indonesia where 590 alien species have been planted, we estimated the effect of four plant traits, plus time since species introduction, on: a) the naturalization probability and b) abundance (density) of...

Relationships between plant-soil feedbacks and functional traits

Nianxun Xi, Peter Adler, Dongxia Chen, Hangyu Wu, Jane Catford, Peter Van Bodegom, Michael Bahn, Kerri Crawford & Chengjin Chu
Plant-soil feedbacks (PSF) and functional traits are two active but not well theoretically integrated areas of research. However, PSF and traits are both affected by life history evolution, so the two should theoretically be related. We provide a conceptual framework to link plant functional traits to two types of PSF metrics, and hypothesize that individual PSF (plant performance in conspecific versus heterospecific soil) should be related to the fast-slow trait spectrum, while pairwise PSF (the...

Carcharhinus amblyrhynchos and Carcharhinus albimarginatus underwater acoustic telemetry data - Chagos Archipelago 2014-2018

Michael Williamson
A wide array of technologies are available for gaining insight into the movement of wild aquatic animals. Although acoustic telemetry may lack the fine-scale resolution of some satellite tracking technologies, the substantially longer battery life can yield important long-term data on behaviour and movement for low per-unit cost. Typically, however, receiver arrays are designed to maximise spatial coverage at the cost of positional accuracy leading to potentially longer detection gaps as individuals move out of...

Clinical features in X-linked myotubular myopathy carriers

Stacha Reumers, Frederik Braun, Jennifer Spillane, Johann Böhm, Maartje Pennings, Meyke Schouten, Anneke Van Der Kooi, Reghan Foley, Carsten Bönnemann, Erik-Jan Kamsteeg, Corrie Erasmus, Ulrike Schara-Schmidt, Heinz Jungbluth & Nicol Voermans
Objective: To characterize the spectrum of clinical features in a cohort of X-linked myotubular myopathy (XL-MTM) carriers, including prevalence, genetic features, clinical symptoms and signs, as well as associated disease burden. Methods: We performed a cross-sectional online questionnaire study among XL-MTM carriers. Participants were recruited from patient associations, medical centers and registries in the United Kingdom, Germany and the Netherlands. We used a custom-made questionnaire, the Checklist Individual Strength (CIS), the Frenchay Activities Index (FAI),...

Fragmentation in trader preferences among multiple markets: Market coexistence versus single market dominance

Aleksandra Alorić, Robin Nicole & Peter Sollich
Technological advancement has lead to an increase in number and type of trading venues and diversification of goods traded. These changes have re-emphasized the importance of understanding the effects of market competition: does proliferation of trading venues and increased competition lead to dominance of a single market or coexistence of multiple markets? In this paper, we address these questions in a stylized model of Zero Intelligence traders who make repeated decisions at which of three...

Prevalence, severity, and risk factors of disability among adults living with HIV accessing routine outpatient HIV care in London, United Kingdom (UK): A cross-sectional self-report study

Darren Brown, Kelly O'Brien, Richard Harding, Phillip Sedgwick, Mark Nelson, Marta Boffito & Agieszka Lewko
Background The study objectives were to measure disability prevalence and severity, and examine disability risk factors, among adults living with HIV in London, United Kingdom (UK). Methods Self-reported questionnaires were administered: World Health Organization Disability Assessment Schedule 2.0 (WHODAS), HIV Disability Questionnaire (HDQ), Equality Act disability definition (EADD), and demographic questionnaire. We calculated proportion (95% Confidence Interval; CI) of “severe” and “moderate” disability measured using EADD and WHODAS scores ≥2 respectively. We measured disability severity...

Experimental study on the seismic behavior of RC columns improved with central large-diameter butted steel rods

Hanming Zhang, Jie Luo, Jianchun Xiao, Jing Chen, Zhuoqun Liu, Yi Zhang, Zongli Luo & Hong Zhang
Abstract A reinforced concrete (RC) column improved with central large-diameter butted steel rods (CLBSR column) has been proposed to increase the limit value of the axial compression ratio. This paper presents the seismic behavior analysis of CLBSR columns subjected to low-cycle reciprocating loading. The CLBSR columns were also compared with the RC column improved with central large-diameter steel rods (CLSR column) and the RC column improved with central reinforcement bars (CRB column) under the same...

Experimental study on the seismic behavior of RC columns improved with central large-diameter butted steel rods

Hanming Zhang, Jie Luo, Jianchun Xiao, Jing Chen, Zhuoqun Liu, Yi Zhang, Zongli Luo & Hong Zhang
Abstract A reinforced concrete (RC) column improved with central large-diameter butted steel rods (CLBSR column) has been proposed to increase the limit value of the axial compression ratio. This paper presents the seismic behavior analysis of CLBSR columns subjected to low-cycle reciprocating loading. The CLBSR columns were also compared with the RC column improved with central large-diameter steel rods (CLSR column) and the RC column improved with central reinforcement bars (CRB column) under the same...

Data from: Neurofunctional abnormalities during sustained attention in severe childhood abuse

Lena Lim, Heledd Hart, Mitul A. Mehta, Andrew Simmons, Kah Mirza & Katya Rubia
Childhood maltreatment is associated with adverse affective and cognitive consequences including impaired emotion processing, inhibition and attention. However, the majority of functional magnetic resonance imaging (fMRI) studies in childhood maltreatment have examined emotion processing, while very few studies have tested the neurofunctional substrates of cognitive functions and none of attention. This study investigated the association between severe childhood abuse and fMRI brain activation during a parametric sustained attention task with a progressively increasing load of...

Data from: Impact of person-centred care training and person-centred activities on quality of life, agitation, and antipsychotic use in people with dementia living in nursing homes: a cluster-randomised controlled trial

Clive Ballard, Anne Corbett, Martin Orrell, Gareth Williams, Esme Moniz-Cook, Renee Romeo, Bob Woods, Lucy Garrod, Ingelin Testad, Barbara Woodward-Carlton, Jennifer Wenborn, Martin Knapp & Jane Fossey
Background: Agitation is a common, challenging symptom affecting large numbers of people with dementia and impacting on quality of life (QoL). There is an urgent need for evidence-based, cost-effective psychosocial interventions to improve these outcomes, particularly in the absence of safe, effective pharmacological therapies. This study aimed evaluate the efficacy of a person-centered care and psychosocial intervention (WHELD) on QoL, agitation and antipsychotic use in people with dementia living in nursing homes, and to determine...

Data from: Clinical spectrum of STX1B-related epileptic disorders

Stefan Wolking, Patrick May, Davide Mei, Rikke S. Møller, Simona Balestrini, Katherine L. Helbig, Cecilia Desmettre Altuzarra, Nicolas Chatron, Charu Kaiwar, Katharina Stoehr, Peter Widdess-Walsh, Bryce A. Mendelsohn, Adam Numis, Maria R. Cilio, Wim Van Paesschen, Lene L. Svendsen, Stephanie Oates, Elaine Hughes, Sushma Goyal, Kathleen Brown, Margarita Sifuentes Saenz, Thomas Dorn, Hiltrud Muhle, Alistair T. Pagnamenta, Dimitris V. Vavoulis … & Julian Schubert
Objective: The aim of this study was to expand the spectrum of epilepsy syndromes related to STX1B, encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants. Methods: We used next generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. To estimate the pathogenicity of the variants, we used established and newly developed in silico prediction tools. Results: We...

Data from: Quantifying niche availability, niche overlap and competition for recruitment sites in plant populations without explicit knowledge of niche axes.

Elizabeth M. Wandrag, Jane A. Catford & Richard P. Duncan
1. Niche availability, niche overlap and competitive ability are key determinants of the distribution and abundance of species. However, quantifying each of these components is difficult because it is not always possible to identify or measure relevant environmental gradients (niche axes) along which species might partition or compete for niche space. 2. We describe a method that uses seed addition experiments to quantify the number of ‘safe-sites’ (microsites suitable for a species to recruit from...

Data from: NMDA receptor antagonists and pain relief: a meta-analysis of experimental trials

Trevor Thompson, Fiona Whiter, Katy Gallop, Nicola Veronese, Marco Solmi, Paul Newton & Brendon Stubbs
OBJECTIVES: We conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of N-methyl-D-aspartate receptor (NMDAR) antagonists. METHODS: Six major databases were systematically searched (to 03/2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis. RESULTS: Searches identified 70 eligible trials (N=1069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease...

Data from: Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron

Elisa Galliano, Eleonora Franzoni, Marine Breton, Annisa Chand, Darren Byrne, Venkatesh N. Murthy & Matthew Grubb
Most neurogenesis in the mammalian brain is completed embryonically, but in certain areas the production of neurons continues throughout postnatal life. The functional properties of mature postnatally-generated neurons often match those of their embryonically-produced counterparts. However, we show here that in the olfactory bulb (OB), embryonic and postnatal neurogenesis produce functionally distinct subpopulations of dopaminergic (DA) neurons. We define two subclasses of OB DA neuron by the presence or absence of a key subcellular specialisation:...

The Inquisitions Post Mortem project

Michael Hicks, Paul Spence, Matthew Holford, Matthew Tompkins, Gordon McKelvie, Miguel Vieira, Neil Jakeman, Charlotte Tupman, David Little, Faith Lawrence & Tim Watts
The Project Mapping the Medieval Countryside is a major research project dedicated to creating a digital edition of the medieval English inquisitions post mortem (IPMs) from c. 1236 to 1509. IPMs recorded the lands held at their deaths by tenants of the crown. They comprise the most extensive and important body of source material for landholding in medieval England. Describing the lands held by thousands of families, from nobles to peasants, they are a key...

Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in mycosis fungoides and Sezary syndrome

Christine Jones, Andrea Degasperi, Vieri Grandi, Tracey Mitchell & Serena Nik-Zainal
T-cell non-Hodgkin’s lymphomas develop following transformation of tissue resident T-cells. We performed a meta-analysis of mutational catalogues derived from whole exome sequencing data from 403 patients with eight subtypes of T-cell non-Hodgkin’s lymphoma to identify mutational signatures and recurrent gene mutations associated with specific causal peaks within these signatures. Signature 1, indicative of age-related deamination, was prevalent across all T-cell lymphoma subtypes, reflecting the derivation of these malignancies from memory T-cell subsets. The majority of...

Data from: Headache study: The management of chronic headache with referral from primary care to direct access to Magnetic Resonance Imaging (MRI) compared to Neurology services: an observational prospective study in London

Tiago Rua
Objectives. To evaluate the cost, accessibility and patient satisfaction implications of two clinical pathways used in the management of chronic headache. Intervention. Management of chronic headache following referral from Primary Care that differed in the first appointment, either a Neurology appointment or an MRI brain scan. Design and setting. A pragmatic, non-randomised, prospective, single-center study at a Central Hospital in London. Participants. Adult patients with chronic headache referred from Primary to Secondary Care. Primary and...

Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss

Neil Jon Ingham, Navid Banafshe, Clarisse Panganiban, Julia L Crunden, Jing Chen, Morag A Lewis & Karen P Steel
Age-related hearing loss in humans (presbycusis) typically involves impairment of high frequency sensitivity before becoming progressively more severe at lower frequencies. Pathologies initially affecting lower frequency regions of hearing are less common. Here we describe a progressive, predominantly low-frequency recessive hearing impairment in two mutant mouse lines carrying different mutant alleles of the Klhl18 gene: a spontaneous missense mutation (Klhl18lowf) and a targeted mutation (Klhl18tm1a(KOMP)Wtsi). Both males and females were studied, and the two mutant...

Comparing climatic suitability and niche distances to explain populations responses to extreme climatic events

María Ángeles Pérez-Navarro
Habitat suitability calculated from Species Distribution Models (SDMs) has been used to assess population performance, but empirical studies have provided weak or inconclusive support to this approach. Novel approaches measuring population distances to niche centroid and margin in environmental space have been recently proposed to explain population performance, particularly when populations experience exceptional environmental conditions that may place them outside of the species niche. Here, we use data of co-occurring species’ decay, gathered after an...

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