3 Works

Data from: In vivo dynamics of skeletal muscle Dystrophin in zebrafish embryos revealed by improved FRAP analysis

Fernanda Bajanca, Vinicio Gonzalez-Perez, Sean J. Gillespie, Cyriaque Beley, Luis Garcia, Eric Theveneau, Richard P. Sear & Simon M. Hughes
Dystrophin forms an essential link between sarcolemma and cytoskeleton, perturbation of which causes muscular dystrophy. We analysed Dystrophin binding dynamics in vivo for the first time. Within maturing fibres of host zebrafish embryos, our analysis reveals a pool of diffusible Dystrophin and complexes bound at the fibre membrane. Combining modelling, an improved FRAP methodology and direct semi-quantitative analysis of bleaching suggests the existence of two membrane-bound Dystrophin populations with widely differing bound lifetimes: a stable,...

Data from: Association between probable postnatal depression and increased infant mortality and morbidity: findings from the DON population-based cohort study in rural Ghana

Benedict Weobong, Augustinus H. A. Ten Asbroek, Seyi Soremekun, Lu Gram, Seeba Amenga-Etego, Samuel Danso, Seth Owusu-Agyei, Martin Prince & Betty R. Kirkwood
Objectives: To assess the impact of probable depression in the immediate postnatal period on subsequent infant mortality and morbidity. Design: Cohort study nested within 4 weekly surveillance of all women of reproductive age to identify pregnancies and collect data on births and deaths. Setting: Rural/periurban communities within the Kintampo Health Research Centre study area of the Brong-Ahafo Region of Ghana. Participants: 16 560 mothers who had a live singleton birth reported between 24 March 2008...

Data from: Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV1

Koa Hosoki, Sun Ying, Christopher Corrigan, Huibin Qi, Alexander Kurosky, Kristofer Jennings, Qian Sun, Istvan Boldogh & Sanjiv Sur
We sought to identify cells and cytokines in bronchoalveolar lavage (BAL) fluids that distinguish asthma from healthy control subjects and those that distinguish controlled asthma from uncontrolled asthma. Following informed consent, 36 human subjects were recruited for this study. These included 11 healthy control subjects, 15 subjects with controlled asthma with FEV1≥80% predicted and 10 subjects with uncontrolled asthma with FEV1 <80% predicted. BAL fluid was obtained from all subjects. The numbers of different cell...

Registration Year

  • 2015
    3

Resource Types

  • Dataset
    3

Affiliations

  • King's College London
    3
  • London School of Hygiene & Tropical Medicine
    1
  • University of Surrey
    1
  • The University of Texas Medical Branch at Galveston
    1
  • Centre de Biologie du Développement
    1
  • Inserm
    1
  • Academic Medical Center
    1
  • King's College
    1
  • Scientific Centre of Monaco
    1
  • Kintampo Health Research Centre
    1