4 Works

Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila

Katja Hoedjes, Joost Van Den Heuvel, Martin Kapun, Laurent Keller, Thomas Flatt & Bas Zwaan
Reproduction and diet are two major factors controlling the physiology of aging and life history, but how they interact to affect the evolution of longevity is unknown. Moreover, while studies of large-effect mutants suggest an important role of nutrient sensing pathways in regulating aging, the genetic basis of evolutionary changes in lifespan remains poorly understood. To address these questions, we analyzed the genomes of experimentally evolved Drosophila melanogaster populations subjected to a factorial combination of...

Data from: Cyclin dependent kinase 5 (CDK5) regulates the circadian clock

Andrea Brenna, Iwona Olejniczak, Rohit Chavan, Jürgen Ripperger, Sonja Langmesser, Elisabetta Cameroni, Zehan Hu, Claudio De Virgilio, Jörn Dengjel & Urs Albrecht
Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. We observed that the cyclin-dependent kinase 5 (CDK5) regulates the mammalian clock involving phosphorylation of PER2. Knock-down of Cdk5 in the suprachiasmatic nuclei (SCN), the...

Ancient mitogenomics clarifies radiation of extinct Mascarene giant tortoises (Cylindraspis spp.)

Christian Kehlmaier, Eva Graciá, Patrick D. Campbell, Margaretha D. Hofmeyr, Silke Schweiger, Albert Martínez-Silvestre, Walter Joyce & Uwe Fritz
The five extinct giant tortoises of the genus Cylindraspis belong to the most iconic species of the enigmatic fauna of the Mascarene Islands that went largely extinct after the discovery of the islands. To resolve the phylogeny and biogeography of Cylindraspis, we analysed a data set of 45 mitogenomes that includes all lineages of extant tortoises and eight near-complete sequences of all Mascarene species extracted from historic and subfossil material. Cylindraspis is an ancient lineage...

Global biogeographic synthesis and priority conservation regions of the relict tree family Juglandaceae

Yi-Gang Song
Abstract Aim: To establish a complete database of Juglandaceae at a spatiotemporal scale and develop a phylogeographic framework with which to elucidate the distributional patterns, diversity patterns, origins, evolution, and conservation priority regions of this family. Location: Worldwide Methods: Data on the distribution of all the extant and fossil species of Juglandaceae were collected, followed by analyses of its latitudinal distribution, elevational distribution, and species and generic diversity. Furthermore, based on all genera and 87%...

Registration Year

  • 2019
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Resource Types

  • Dataset
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Affiliations

  • University of Fribourg
    4
  • University of the Western Cape
    1
  • Senckenberg Nature Research Society
    1
  • Natural History Museum
    1
  • University of Lausanne
    1
  • Miguel Hernandez University
    1
  • Government of Catalonia
    1
  • Naturhistorisches Museum
    1
  • University of Zurich
    1
  • Wageningen University & Research
    1