10 Works

Data from: Repetitive DNA profiles reveal evidence of rapid genome evolution and reflect species boundaries in ground beetles

John Sproul, Lindsey Barton & David Maddison
Genome architecture is a complex, multidimensional property of an organism defined by the content and spatial organization of the genome’s component parts. Comparative study of entire genome architecture in model organisms is shedding light on mechanisms underlying genome regulation, evolution, and diversification; but such studies require costly analytical approaches which make extensive comparative study impractical for most groups. However, lower-cost methods that measure a single architectural component (e.g., distribution of one class of repeats) have...

Constitutive model of erythrocyte membranes with distributions of spectrin orientations and lengths - pipette aspiration data and MatLab Code

Richard Waugh & Zhangli Peng
The speadsheet contains the original micropipette aspiration measurement of red blood cell membrane. There are five days of experiment each on its own tab, the first three of which are reported in the manuscript. The MatLab code used to generate theoretical predictions based on our new microstructurebased constitutive model are also included. This is the code used to generate least squared regression values for the material coefficients.

Slave Movement -- Slave Trade to Jamaica, 1782-1788, 1805-1808

Herbert S. Klein & Stanley L. Engerman

Data from: Genomic regions underlying metabolic and neuronal signaling pathways are temporally consistent outliers in a moving avian hybrid zone

Dominique Wagner, Robert Curry, Nancy Chen, Irby Lovette & Scott Taylor
The study of hybrid zones can provide insight into the genetic basis of species differences that are relevant for the maintenance of reproductive isolation. Hybrid zones can also provide insight into climate change, species distributions, and evolution. The hybrid zone between black-capped chickadees (Poecile atricapillus) and Carolina chickadees (P. carolinensis) is shifting northward in response to increasing winter temperatures but is not increasing in width. This pattern indicates strong selection against chickadees with admixed genomes....

Extreme developmental instability is associated with the pea aphid wing plasticity

Rachel Hammelman, Carrie Heusinkveld, Emily Hung, Alydia Meinecke, Benjamin Parker & Jennifer Brisson
A key focus of evolutionary developmental biology is on how phenotypic diversity is generated. In particular, both plasticity and developmental instability can contribute to phenotypic variation among genetically identical individuals, but the interactions between the two phenomena and their general fitness impacts are unclear. We discovered a striking example of asymmetry in pea aphids: the presence of wings on one side and the complete or partial absence of wings on the opposite side. We used...

Data from: Phylogenomic analysis of Wolbachia strains reveals patterns of genome evolution and recombination

Xu Wang, Xiaozhu Wang, Xiao Xiong, Wenqi Cao, Chao Zhang & John Werren
Wolbachia are widespread intracellular bacteria that mediate many important biological processes in arthropod species. In this study, we identified 210 conserved single-copy genes in 33 genome-sequenced Wolbachia strains in the A, B, C, D, E and F supergroups. Phylogenomic analysis with these core genes indicate that all 33 Wolbachia strains maintain the supergroup relationship classified previously based on the multilocus sequence typing (MLST) genes. Using an interclade recombination screening method, 14 inter-supergroup recombination events were...

Endothelial glycocalyx layer properties and its ability to limit leukocyte adhesion

Luis Delgadillo
The endothelial glycocalyx layer (EGL), consisting of long proteoglycans protruding from the endothelium, acts as a regulator of inflammation by preventing leukocyte engagement with adhesion molecules on the endothelial surface. The amount of resistance to adhesive events the EGL provides is the result of two properties: EGL thickness and stiffness. To determine these, we used an atomic force microscope to indent the surfaces of cultured endothelial cells with a glass bead and evaluated two different...

PRISM-HD: Patient-Reported Impact of Symptoms in Huntington Disease

Alistair M Glidden, Elizabeth A Luebbe, Molly J Elson, Steven B Goldenthal, Christopher W Snyder, Christine E Zizzi, E Ray Dorsey & Chad R Heatwole
OBJECTIVE: To determine the frequency and relative importance of symptoms experienced by adults with Huntington disease (HD) and to identify factors associated with a higher disease burden. METHODS: We performed 40 qualitative interviews (n = 20 with HD, n = 20 caregivers) and analyzed 2,082 quotes regarding the symptomatic burden of HD. We subsequently performed a cross-sectional study with 389 participants (n = 156 with HD [60 of whom were prodromal], n = 233 caregivers)...

Dynamic evolution of euchromatic satellites on the X chromosome in Drosophila melanogaster and the simulans clade

J.S. Sproul, D.E. Khost, D.G. Eickbush, S. Negm, X. Wei, I. Wong & A.M. Larracuente
ABSTRACTSatellite DNAs (satDNAs) are among the most dynamically evolving components of eukaryotic genomes and play important roles in genome regulation, genome evolution, and speciation. Despite their abundance and functional impact, we know little about the evolutionary dynamics and molecular mechanisms that shape satDNA distributions in genomes. Here we use high-quality genome assemblies to study evolutionary dynamics of two complex satDNAs, Rsp-like and 1.688 gm/cm3, in Drosophila melanogaster and its three nearest relatives in the simulans...

Data from: Osteosarcopenia in reproductive-aged women with polycystic ovary syndrome: a multicenter case-control study

Maryam Kazemi, Brittany Jarrett, Stephen Parry, Anna Thalacker-Mercer, Kathleen Hoeger & Steven Spandorfer
Context: Osteosarcopenia (loss of skeletal muscle and bone mass and/or function usually associated with aging) shares pathophysiological mechanisms with polycystic ovary syndrome (PCOS). However, the relationship between osteosarcopenia and PCOS remains unclear. Objective: We evaluated skeletal muscle index% (SMI%=[appendicular muscle mass/weight {kg}]×100) and bone mineral density (BMD) in PCOS (hyperandrogenism+oligoamenorrhea), and contrasted these musculoskeletal markers against 3 reproductive phenotypes: (1) HA (hyperandrogenism+eumenorrhea); (2) OA (normoandrogenic+oligoamenorrhea) and, (3) controls (normoandrogenic+eumenorrhea). Endocrine predictors of SMI% and BMD...

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