7 Works

Data from: Multiple evolutionary origins of Trypanosoma evansi in Kenya

Christine M. Kamidi, Norah P. Saarman, Kirstin B. Dion, Paul O. Mireji, Collins Ouma, Grace Murilla, Serap Aksoy, Achim Schnaufer, Adalgisa Caccone & Kirstin Dion
Trypanosoma evansi is the parasite causing surra, a form of trypanosomiasis in camels and other livestock, and a serious economic burden in Kenya and many other parts of the world. Trypanosoma evansi transmission can be sustained mechanically by tabanid and Stomoxys biting flies, whereas the closely related African trypanosomes T. brucei brucei and T. b. rhodesiense require cyclical development in tsetse flies (genus Glossina) for transmission. In this study, we investigated the evolutionary origins of...

Data from: Temporal genetic differentiation in Glossina pallidipes tsetse fly populations in Kenya

Winnie A. Okeyo, Norah P. Saarman, Michael Mengual, Kirstin Dion, Rosemary Betata, Paul O. Mireji, Sylvance Okoth, Johnson O. Ouma, Collins Ouma, Joel Ochieng, Grace Murilla, Serap Aksoy & Adalgisa Caccone
Background: Glossina pallidipes is a major vector of both Human and Animal African Trypanosomiasis (HAT and AAT) in Kenya. The disease imposes economic burden on endemic regions in Kenya, including south-western Kenya, which has undergone intense but unsuccessful tsetse fly control measures. We genotyped 387 G. pallidipes flies at 13 microsatellite markers to evaluate levels of temporal genetic variation in two regions that have been subjected to intensive eradication campaigns from the 1960s to the...

Data from: Hepatitis B virus sero-profiles and genotypes in HIV-1 infected and uninfected injection and non-injection drug users from coastal Kenya

Mark W. Kilongosi, Valentine Budambula, Raphael Lihana, Francis O. Musumba, Anthony K. Nyamache, Nancy L. M. Budambula, Aabid A. Ahmed, Collins Ouma & Tom Were
Background: Information about HBV sero-markers, infection stages and genotypes in HIV-1 infected and uninfected injection and non-injection drug users (IDUs) in Kenya remains elusive. Methods: A cross-sectional study examining HBV sero-marker, infection stages and genotypes was conducted among HIV-1 infected and uninfected, respectively, IDUs (n = 157 and n = 214) and non-IDUs (n = 139 and n = 48), and HIV-1 uninfected non-drug using controls (n = 194) from coastal, Kenya. HBV sero-marker and...

A machine learning approach to integrating genetic and ecological data in tsetse flies (Glossina pallidipes) for spatially explicit vector control planning

Anusha Bishop, Giuseppe Amatulli, Chaz Hyseni, Evlyn Pless, Rosemary Bateta, Winnie Okeyo, Paul Mireji, Sylvance Okoth, Imna Malele, Grace Murilla, Serap Aksoy & Norah Saarman
Introduction - Control of vector populations is an effective strategy for addressing vector-borne disease transmission. Effective vector control requires knowledge of habitat use and connectivity. Our goal was to improve this knowledge for the tsetse species Glossina pallidipes, a vector of animal African trypanosomiasis, which is a wasting disease in livestock and represents a serious socioeconomic burden across sub-Saharan Africa. Methods and Results - We used random forest regression to: (i) Build and integrate models...

Data from: Complete blood count reference intervals from a healthy adult urban population in Kenya

Geoffrey Omuse, Daniel Maina, Jane Mwangi, Caroline Wambua, Kiran Radia, Alice Kanyua, Elizabeth Kagotho, Mariza Hoffman, Peter Ojwang, Zul Premji, Kiyoshi Ichihara & Rajiv Erasmus
Background: There are racial, ethnic and geographical differences in complete blood count (CBC) reference intervals (RIs) and therefore it is necessary to establish RIs that are population specific. Several studies have been carried out in Africa to derive CBC RIs but many were not conducted with the rigor recommended for RI studies hence limiting the adoption and generalizability of the results. Method: By use of a Beckman Coulter ACT 5 DIFF CP analyser, we measured...

Additional file 3 of Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs

Dancan M. Wakoli, Bartholomew N. Ondigo, Douglas O. Ochora, Joseph G. Amwoma, Winnie Okore, Edwin W. Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H. Opot, Agnes C. Cheruiyot, Dennis Juma, Amanda Roth, Benhards R. Ogutu, Daniel Boudreaux, Ben Andagalu & Hoseah M. Akala
Additional file 3:. Growth inhibition and genomic end point study data.

Additional file 3 of Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs

Dancan M. Wakoli, Bartholomew N. Ondigo, Douglas O. Ochora, Joseph G. Amwoma, Winnie Okore, Edwin W. Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H. Opot, Agnes C. Cheruiyot, Dennis Juma, Amanda Roth, Benhards R. Ogutu, Daniel Boudreaux, Ben Andagalu & Hoseah M. Akala
Additional file 3:. Growth inhibition and genomic end point study data.

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