13 Works

The lncRNA RHPN1-AS1 downregulation promotes gefitinib resistance by targeting miR-299-3p/TNFSF12 pathway in NSCLC

Xuehao Li, Xin Zhang, Chunlu Yang, Su Cui, Qiming Shen & Shun Xu
Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) gefitinib has exhibited notable clinical efficacy in non-small cell lung cancer (NSCLC) patients. However, its therapeutic efficacy is ultimately limited by the development of gefitinib resistance. The present study aimed to investigate the effects of the long non-coding RNA, RHPN1-AS1 on gefitinib resistance in NSCLC and explore the underlying mechanisms. In this study, RHPN1-AS1 was observed to be downregulated in gefitinib resistant patients and NSCLC...

Data from: Evolutionary history of the angiosperm flora of China

Li-Min Lu, Ling-Feng Mao, Tuo Yang, Jian-Fei Ye, Bing Liu, Hong-Lei Li, Miao Sun, Joseph T. Miller, Sarah Mathews, Hai-Hua Hu, Yan-Ting Niu, Dan-Xiao Peng, You-Hua Chen, Stephen A. Smith, Min Chen, Kun-Li Xiang, Chi-Toan Le, Viet-Cuong Dang, An-Ming Lu, Pamela S. Soltis, Douglas E. Soltis, Jian-Hua Li & Zhi-Duan Chen
High species diversity may result from recent rapid speciation in a ‘cradle’ and/or the gradual accumulation and preservation of species over time in a ‘museum’1,2. China harbours nearly 10% of angiosperm species worldwide and has long been considered as both a museum, owing to the presence of many species with hypothesized ancient origins3,4, and a cradle, as many lineages have originated as recent topographic changes and climatic shifts—such as the formation of the Qinghai–Tibetan Plateau...

Data from: A novel in-situ stress measurement method based on acoustic emission kaiser effect: a theoretical and experimental study

Xin Bai, Dongming Zhang, Hao Wang, Shujian Li, Zi Rao, Shu-Jian Li & Dong-Ming Zhang
Measurement of in-situ stress is critical to understand the deformation and destruction of the underground space surrounding rock, and dynamic disaster of the coal mine. At present, with the increasing depth of mining, in-situ stress parameters is more and more important for coal mine. In this paper, a novel method for in-situ stress measurement with Kaiser effect was studied and applied in the Baijiao coal mine. First, we presented a comprehensive analysis method for the...

Data from: Electrokinetic remediation of heavy metals from municipal solid waste incineration fly ash pretreated by nitric acid

Huilin Li, Faheem Muhammad, Yujie Yan, Manli Zhang, Binquan Jiao, Lin Yu & Dongwei Li
Municipal Solid Waste Incineration (MSWI) fly ash has high concentration of Heavy Metals (HMs) which are hazardous to environment. Moreover, it has high pH and buffering capacity which hinders the removal of HMs. Another constraining factor is considerable fraction of HMs which existe in oxidizable and reducible states. The acid pretreatment of MSWI fly ash is key solution to these problem. Therefore, current experiment is carried out to evaluate the effect of acid pretreatment of...

Expression of circular RNAs during C2C12 myoblast differentiation and prediction of coding potential based on the number of open reading frames and N6-methyladenosine motifs

Rui Chen, Ting Jiang, Si Lei, Yanling She, Huacai Shi, Shanyao Zhou, Jun Ou & Yulin Liu
The importance of circular RNAs (circRNAs) as regulators of muscle development and muscle-associated disorders is becoming increasingly apparent. To explore potential regulators of muscle differentiation, we determined the expression profiles of circRNAs of skeletal muscle C2C12 myoblasts and myotubes using microarray analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to explore circRNA functions. We also established competing endogenous RNA (ceRNA) networks using bioinformatics methods and predicted the coding...

Expression of circular RNAs during C2C12 myoblast differentiation and prediction of coding potential based on the number of open reading frames and N6-methyladenosine motifs

Rui Chen, Ting Jiang, Si Lei, Yanling She, Huacai Shi, Shanyao Zhou, Jun Ou & Yulin Liu
The importance of circular RNAs (circRNAs) as regulators of muscle development and muscle-associated disorders is becoming increasingly apparent. To explore potential regulators of muscle differentiation, we determined the expression profiles of circRNAs of skeletal muscle C2C12 myoblasts and myotubes using microarray analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to explore circRNA functions. We also established competing endogenous RNA (ceRNA) networks using bioinformatics methods and predicted the coding...

Oxidative stress and NF-κB signaling are involved in LPS induced pulmonary dysplasia in chick embryos

Yun Long, Guang Wang, Ke Li, Zongyi Zhang, Ping Zhang, Jing Zhang, Xiaotan Zhang, Yongping Bao, Xuesong Yang & Pengcheng Wang
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, the precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness of alveolar gas exchange zone, and accumulation of PAS+ immature pulmonary cells, accompanied with reduced expression of alveolar epithelial cell markers and lamellar body count. Upon LPS exposure, pulmonary cell proliferation was...

Data from: Factors affecting N-nitrosodimethylamine formation from poly(diallyldimethyl-ammonium chloride) degradation during chloramination

Siying Tan, Shaojie Jiang, Xiaoyu Li & Qiuhong Yuan
Poly (diallyldimethyl ammonium chloride) (polyDADMAC) has been shown to be an important precursor of the probable human carcinogen N-nitrosodimethylamine (NDMA) when in contact with chloramine. In this study, we conducted an orthogonal experiment design to evaluate the effects of pH values, ammonia, bromide, natural organic matter (NOM) and monochloramine dosages on the formation of NDMA from polyDADMAC during chloramination. Meanwhile, single factor experiments of pH, bromide and NOM prove the results of orthogonal experiment. The...

Data from: Wake-induced oscillation behavior of twin bundle conductor transmission lines

Chuan Wu, Bo Yan, Guizao Huang, Bo Zhang, Zhongbin Lv & Qing Li
A numerical method to simulate air flow around a bundle conductor line by means of FLUENT software is presented and verified by a wind tunnel test for aerodynamic characteristics of a twin bundle conductor line. The lift and drag coefficients of the leeward sub-conductor of a twin bundle conductor varying with its relative position in the wake zone to the windward one under different wind velocities are numerically determined by the presented method. A user-defined...

Oxidative stress and NF-κB signaling are involved in LPS induced pulmonary dysplasia in chick embryos

Yun Long, Guang Wang, Ke Li, Zongyi Zhang, Ping Zhang, Jing Zhang, Xiaotan Zhang, Yongping Bao, Xuesong Yang & Pengcheng Wang
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, the precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness of alveolar gas exchange zone, and accumulation of PAS+ immature pulmonary cells, accompanied with reduced expression of alveolar epithelial cell markers and lamellar body count. Upon LPS exposure, pulmonary cell proliferation was...

RETRACTED ARTICLE: The lncRNA RHPN1-AS1 downregulation promotes gefitinib resistance by targeting miR-299-3p/TNFSF12 pathway in NSCLC

Xuehao Li, Xin Zhang, Chunlu Yang, Su Cui, Qiming Shen & Shun Xu
We, the Editors and Publisher of the journal Cell Cycle, have retracted the following article: Xuehao Li, Xin Zhang, Chunlu Yang, Sui Cui, Qiming Shen and Shun Xu. The lncRNA RHPN1-AS1 downregulation promotes gefitinib resistance by targeting miR-299-3p/TNFSF12 pathway in NSCLC. Cell Cycle. 2018;17(14):1772-1783. doi: 10.1080/15384101.2018.1496745 Since publication, concerns have been raised about the integrity of the data in the article. When approached for an explanation, the authors have been unable to address the concerns...

Oxidative Stress and NF-κB signaling are involved in LPS induced pulmonary dysplasia in chick embryos

Yun Long, Guang Wang, Ke Li, Zong-yi Zhang, Ping Zhang, Jing Zhang, Xiao-tan Zhang, Yongping Bao, Xuesong Yang & Peng-cheng Wang
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, the precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness of alveolar gas exchange zone, and accumulation of PAS+ immature pulmonary cells, accompanied with reduced expression of alveolar epithelial cell markers and lamellar body count. Upon LPS exposure, pulmonary cell proliferation was...

Data from: Petrophysical characterization of high-rank coal by nuclear magnetic resonance: a case study of the Baijiao coal reservoir, SW China

Dongming Zhang, Yapei Chu, Shujian Li, Yushun Yang, Xin Bai, Chen Ye & Decai Wen
To better apply nuclear magnetic resonance (NMR) to evaluate the petrophysical characterization of high-rank coal, six anthracite samples from the Bajiao coal reservoir were measured by NMR. The porosity, T2 cutoff value, permeability, and pore type were analysed using the transverse relaxation time (T2) spectrum before and after centrifugation. The results show that the T2 spectrum of water-saturated anthracite can be divided into a discontinuous and continuous trimodal distribution. According to the connectivity among pores,...

Registration Year

  • 2018
    13

Resource Types

  • Dataset
    13

Affiliations

  • Chongqing University
    13
  • University of Chinese Academy of Sciences
    6
  • Chinese Academy of Sciences
    5
  • Jilin University
    4
  • Shandong University
    4
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    4
  • First Affiliated Hospital of Xi'an Jiaotong University
    4
  • Anhui Agricultural University
    4
  • Zhengzhou University
    4
  • Hong Kong Polytechnic University
    3