2 Works

Data from: Serum neurofilament light: a biomarker of neuroaxonal injury after ischemic stroke

Steffen Tiedt, Marco Duering, Christian Barro, Asli Gizem Kaya, Julia Boeck, Felix J. Bode, Matthias Klein, Franziska Dorn, Benno Gesierich, Lars Kellert, Birgit Ertl-Wagner, Michael W. Goertler, Gabor C. Petzold, Jens Kuhle, Frank Arne Wollenweber, Nils Peters & Martin Dichgans
Objective: To explore the utility of serum neurofilament light chain (sNfL) as a biomarker for primary and secondary neuroaxonal injury after ischemic stroke (IS) and study its value for the prediction of clinical outcome. Methods: We used an ultrasensitive single-molecule array (Simoa) assay to measure sNfL levels in healthy controls (HC, N=30) and two independent cohorts of patients with IS: (1) with serial serum sampling at hospital arrival (N=196), at days 2, 3, and 7...

Data from: Early MoCA predicts long-term cognitive and functional outcome and mortality after stroke

Vera Zietemann, Marios K Georgakis, Thibaut Dondaine, Claudia Müller, Anne-Marie Mendyk, Anna Kopczak, Hilde Hénon, Stéphanie Bombois, Frank Arne Wollenweber, Régis Bordet & Martin Dichgans
Objective: To examine whether the Montreal Cognitive Assessment (MoCA) administered within 7 days after stroke predicts long-term cognitive impairment, functional impairment, and mortality. Methods: MoCA was administered to 274 patients from two prospective hospital-based cohort studies in Germany (n=125) and France (n=149). Cognitive and functional outcomes were assessed at 6, 12 and 36 months post-stroke by comprehensive neuropsychological testing, the Clinical Dementia Rating (CDR) scale, modified Rankin Scale (mRS), and Instrumental Activities of Daily Living...

Registration Year

  • 2018
    2

Resource Types

  • Dataset
    2

Affiliations

  • Munich Cluster for Systems Neurology
    2
  • University Hospital Bonn
    1
  • University of Lille
    1
  • University of Basel
    1
  • German Center for Neurodegenerative Diseases
    1
  • University Hospital of Basel
    1
  • Ludwig Maximilian University of Munich
    1