26 Works

Surgical volume during the covid pandemic: a statistical analysis plan

Tom Dobbs, John Gibson, Alex Fowler & Tom Abbott
Developed in Q4 2020 for prospective analysis of hospital episode statistics and patient episode database of Wales data.

Terrestrial laser scanning (TLS) data on tree crown morphology and neighbourhood competition from both Cuellar and Alto Tajo, Spain

Harry Owen, Emily Lines & William Flynn
1. Tree crown morphology is a key driver of forest dynamics, determining not only the competitiveness of an individual but also the competitive effect exerted on neighbouring trees. Multiple ecological theories, including Metabolic Scaling Theory (MST), predict crown morphology from first principles, but typically lack consideration of competition. The accurate quantification of crown morphology to test theoretical predictions, and the canopy interactions that could alter them, has historically been limited by the simplicity and associated...

Habitat structure mediates vulnerability to climate change through its effects on thermoregulatory behavior

Lauren Neel, Michael Logan, Daniel Nicholson, Christina Miller, Albert Chung, Inbar Maayan, Zach Degon, Madeline DuBois, John David Curlis, Q Taylor, Kaitlin Keegan, Owen McMillan, Jonathan Losos & Christian Cox
Tropical ectotherms are thought to be especially vulnerable to climate change because they are thermal specialists, having evolved in aseasonal thermal environments. However, even within the tropics, habitat structure can influence opportunities for behavioral thermoregulation. Open (and edge) habitats likely promote more effective thermoregulation due to the high spatial heterogeneity of the thermal landscape, while forests are thermally homogenous and may constrain opportunities for behavioral buffering of environmental temperatures. Nevertheless, the ways in which behavior...

Adaptation of the small intestine to microbial enteropathogens in Zambian children with stunting

Paul Kelly, Beatrice Amadi, Kanekwa Zyambo, Kanta Chandwe, Ellen Besa, Chola Mulenga, Simutanyi Mwakamui, Stepfanie Siyumbwa, Sophie Croft, Rose Banda, Miyoba Chipunza, Kapula Chifunda, Lydia Kazhila & Kelley VanBuskirk
Environmental enteropathy is a major contributor to growth faltering in millions of children in Africa and South Asia. We carried out a longitudinal, observational and interventional study in Lusaka, Zambia, of 297 children with stunting (aged 2–17 months at recruitment) and 46 control children who had good growth (aged 1–5 months at recruitment). Control children contributed data only at baseline. Children were provided with nutritional supplementation of daily cornmeal-soy blend, an egg and a micronutrient...

Data from: Body size and shape responses to warming and resource competition

Hanrong Tan, Andrew Hirst, David Atkinson & Pavel Kratina
Body size is a fundamental trait that impacts many aspects of species biology and ecology. It is in turn influenced by a suite of environmental factors, and often decreases with warming. Although environmental conditions can also impact body shape, which is another functional trait that influences locomotion, resource acquisition, and potentially physiological processes, such responses are poorly understood and rarely quantified. We experimentally tested the independent and combined effects of environmental temperature, resource level, and...

Chronic disease within the NHS surgical population: An epidemiological study statistical analysis plan

Alexander J Fowler, John Prowle, RM Pearse & David Cromwell
Statistical Analysis Plan

Pervasive decline of subtropical aquatic insects over 20 years driven by water transparency, non-native fish and stoichiometric imbalance

Gustavo Q. Romero, Dieison Moi, Liam Nash, Pablo Antiqueira, Roger Mormul & Pavel Kratina
Insect abundance and diversity are declining worldwide. Although recent research found freshwater insect populations to be increasing in some regions, there is a critical lack of data from tropical and subtropical regions. Here we examine a 20-year monitoring data set of freshwater insects from a subtropical floodplain comprising a diverse suite of rivers, shallow lakes, channels and backwaters. We found a pervasive decline in abundance of all major insect orders (Odonata, Ephemeroptera, Trichoptera, Megaloptera, Coleoptera,...

Comorbid disease and ethnicity in emergency hospital admissions in east London

Yize I Wan, Zudin Puthucheary & John R Prowle

Pedigree-based and phylogenetic methods support surprising patterns of mutation rate and spectrum in the gray mouse lemur

Ryan Campbell, George Tiley, Jelmer Poelstra, Kelsie Hunnicutt, Peter Larsen, Hui-Jie Lee, Jeffrey Thorne, Mario Dos Reis & Anne Yoder
Mutations are the raw material on which evolution acts, and knowledge of their frequency and genomic distribution is crucial for understanding how evolution operates at both long and short timescales. At present, the rate and spectrum of de novo mutations have been directly characterized in relatively few lineages. Our study provides the first direct mutation rate estimate for a strepsirrhine (i.e., the lemurs and lorises), which comprise nearly half of the primate clade. Using high-coverage...

Bat phylogenetic responses to regenerating Amazonian forests

Fábio Z. Farneda, Ricardo Rocha, Sabhrina Gita Aninta, Adrià López-Baucells, Erica M. Sampaio, Jorge M. Palmeirim, Paulo E. D. Bobrowiec, Cristian S. Dambros & Christoph F. J. Meyer
1. Throughout the tropics, regenerating secondary forests occupy vast areas previously cleared for agriculture and cattle ranching. However, despite the importance of regenerating forests in mitigating the pervasive negative consequences of forest loss and fragmentation on forest-associated biodiversity, longitudinal studies on species’ phylogenetic responses to matrix regeneration are rare. 2. We surveyed bats in continuous primary forest, primary forest fragments and in the regenerating secondary forest matrix of a whole-ecosystem Amazonian fragmentation experiment, ~15 and...

Processing code for optical characterization of flat capillary waves

Radomir Slavchov, Boyan Peychev & Ahmed Ismail

Large‐scale genome sampling reveals unique immunity and metabolic adaptations in bats

Diana Daniela Moreno Santillan, Tanya Lama, Yocelyn T Gutierrez Guerrero, Zixia Huang, Graham Hughes, Alexis Brown, Paul Donat, Huabin Zhao, Stephen Rossiter, Laurel Yohe, Joshua Potter, Emma Teeling, Sonja Vernes, Kalina Davies, Eugene Myers, Federico Hoffmann, Angelique Corthals, David Ray & Liliana Davalos
Comprising more than 1,400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity given small body size, and extraordinary immunity. Some of the molecular mechanisms underlying these unique adaptations includes DNA repair, metabolism and immunity. However, analyses have been limited to a few divergent lineages, reducing the scope of inferences on gene family evolution across the Order Chiroptera. We conducted an exhaustive comparative genomic study of 37 bat species encompassing a large...

The influence of instrumental parameters on the particle-surface interaction measurements using colloidal probe AFM in viscous liquids

Yao Lu, Jurriaan Gillissen, Anastasia Papadopoulou, Guanjie He & Manish Tiwari
Understanding surface adhesion in liquids is of great significance for both fundamental study of suspension rheology and industry such as suspension mixing. However, the key factors that influence adhesion between non-deformable particles and surfaces in highly viscous fluids have not been well understood. Here we used colloidal probe atomic force microscope (AFM) techniques to study the adhesion forces △F in viscous liquids by tuning the instrumental parameters such as contact force, contact time, approach and...

Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis

Imran Khan, Catherine Marelia-Bennet, Julia Lefler, Mariyam Zuberi, Eric Denbaum, Akiko Koide, Dean M. Connor, Ann-Marie Broome, Thierry Pécot, Cynthia Timmers, Michael C. Ostrowski, Shohei Koide & John P. O’Bryan
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). Although pharmacological inhibition of RAS has been challenging, KRAS(G12C)-specific inhibitors have recently entered the clinic. While KRAS(G12C) is frequently expressed in lung cancers, it is rare in PDAC. Thus, more broadly efficacious RAS inhibitors are...

Cross-sectional comparisons of sodium content in processed meat and fish products among five countries - potential for feasible targets and reformulation

Yuzhu Song, Yuzhu Song, Yuan Li, Chunlei Guo, Yishan Wang, Liping Huang, Monique Tan, Feng J He, Terry Harris, Graham MacGregor, Jingmin Ding, Le Dong, Yu Liu, Huijun Wang, Puhong Zhang, Yuxia Ma, Yuzhu Song, Yuan Li, Chunlei Guo, Yishan Wang, Liping Huang, Monique Tan, Feng J He, Terry Harris, Graham MacGregor … & Yuxia Ma
ABSTRACT Introduction: Reducing sodium intake has been identified as a highly cost-effective strategy to prevent and control of high blood pressure and reduce cardiovascular mortality. This study aims to compare the sodium content in processed meat and fish products among five countries, which will contribute to the evidence-base for feasible strategies of sodium reduction in such products. Methods: Sodium content on product labels of 26500 prepackaged products, 19601 meat and 6899 fish, was collected in...

Data from: High summer macrophyte cover increases abundance, growth and feeding of juvenile Atlantic salmon

Jessica E. Marsh, Rasmus B. Lauridsen, Stephen D. Gregory, Pavel Kratina, Luke J. Scott, Dave Cooling & J. Iwan Jones
Aquatic habitats are severely threatened by human activities. For anadromous species, managing freshwater habitats to maximise production of more, larger juveniles could improve resilience to threats in marine habitats and enhance population viability. In some juvenile salmonid habitats, complexity created by large substrates provides resources and reduces competitive interactions, thereby promoting juvenile production. In lowland rivers, which lack large substrates, aquatic plants might provide similar complexity and enhance fish productivity. To test the influence of...

Electron flow during photosynthesis is regulated by location of Ferredoxin:NADP(H) Oxidoreductase

Guy Hanke
During photosynthesis, electron transport is necessary for carbon assimilation and must be regulated to minimise free radical damage. There is a longstanding controversy over the role of a critical enzyme in this process (ferredoxin:NADP(H) oxidoreductase, or FNR), and in particular its location within chloroplasts. Here we use immunogold labelling to prove that FNR previously assigned as soluble is in fact membrane associated. We combined this technique with a genetic approach in the model plant Arabidopsis,...

In-depth comparative toxicogenomics of glyphosate and Roundup herbicides: Histopathology, transcriptome and epigenome signatures, and DNA damage

Robin Mesnage, Mariam Ibragim, Daniele Mandrioli, Laura Falcioni, Eva Tibaldi, Inger Brandsma, Fiorella Belpoggi, Emma Bourne, Emanuel Savage, Charles A Mein & Michael Antoniou
Whether or not glyphosate activates cellular mechanisms involved in carcinogenesis remains controversial. We tested whether glyphosate and three glyphosate-based commercial herbicide formulations activate mechanisms known to be key characteristics of carcinogens. The mammalian stem cell-based genotoxicity ToxTracker assay showed that the representative EU formulation Roundup MON 52276 and the UK formulation Roundup MON 76473, but not glyphosate and the US Roundup formulation MON 76207, activated oxidative stress and unfolded protein responses. High-throughput molecular profiling of...

De Novo Designed Peptide and Protein Hairpins Self-assemble into Sheets and Nanoparticles

Johanna Galloway, Harriet E. V. Bray, Deborah K. Shoemark,, Lorna R. Hodgson, Jennifer Coombs, Judith M. Mantell, Ruth S. Rose, James F. Ross,, Caroline Morris, Robert L. Harniman, Christopher W. Wood, Christopher Arthur, Paul Verkade & Derek N. Woolfson
AFM, TEM, fluorescence microscopy image files and spectral data published in DOI:10.1002/smll.202100472. Preprint of this is available at bioRxiv DOI:10.1101/2020.08.14.251462

Strong sexual selection fails to protect against inbreeding-driven extinction in a moth

Jonathan Parrett, Veroncia Ghobert, Fenn Cullen & Robert Knell
Sexual selection is predicted to influence population persistence because skew in male reproductive success may facilitate the purging of mutation load. We manipulated the strength of sexual selection in populations of Indian meal moths, Plodia interpunctella, by biasing adult sex ratios to be either male- or female-biased, leading to strong and weak sexual selection in males, respectively. After between 19 and 22 generations of experimental evolution we examined whether mutation load differed between these populations...

Warming of aquatic ecosystems disrupts aquatic-terrestrial linkages in the tropics

Liam Nash, Pablo Antiqueira, Gustavo Romero, Paula De Omena & Pavel Kratina
Aquatic ecosystems are tightly linked to terrestrial ecosystems by exchanges of resources, which influence species interactions, community dynamics and functioning in both ecosystem types. However, our understanding of how this coupling responds to climate warming is restricted to temperate, boreal, and arctic regions, with limited knowledge from tropical ecosystems. We investigated how warming aquatic ecosystems impacts cross-ecosystem exchanges in the tropics, through the export of aquatic resources into the terrestrial environment and the breakdown of...

Dataset for the study of Ultrafast energy transfer between lipid-linked chromophores and plant Light-Harvesting Complex II

Ashley Hancock, Minjung Son, Muath Nairat, Tiejun Wei, Lars Jeuken, Christopher Duffy, Gabriela Schlau-Cohen & Peter Adams
This dataset shows the raw data, analysed data and documentation related to figures and tables from the study “Ultrafast energy transfer between lipid-linked chromophores and plant Light-Harvesting Complex II". This includes: absorbance and fluorescence spectra; molecular dynamics images and associated files; calculations of excitation energy transfer; other graphical analyses; tabulated numerical data.

Acute Kidney Injury in COVID-19: secondary analysis of prospective data from the EthICAL study

Yize I Wan, Zuzanna Bien & John R Prowle

Interrogating discordance resolves relationships in the rapid radiation of Old World fruit bats (Chiroptera: Pteropodidae)

Nicolas Nesi, Stephen Rossiter, Michael McGowen, Georgia Tsagkogeorga, Burton Lim, Susan Tsang, Violaine Nicolas, Aude Lalis, Silke Riesle Sbarbaro, Sigit Wiantoro, Alan Hitch, Javier Juste, Corinna Pinzari, Frank Bonaccorso, Nancy Simmons, Annette Scanlon & Christopher Todd
The family Pteropodidae (Old World fruit bats) comprises >200 species distributed across the Old World tropics and subtropics. Most pteropodids feed on fruit, suggesting an early origin of frugivory, although several lineages have shifted to nectar-based diets. Pteropodids are of exceptional conservation concern with >50% of species considered threatened, yet the systematics of this group has long been debated, with uncertainty surrounding early splits attributed to an ancient rapid diversification. Resolving the relationships among the...

Usability of electronic health record systems in UK emergency departments

Ben Bloom
Background The large volume of patients, rapid staff turnover and high work pressure means that the usability of all systems within the Emergency Department (ED) is important. The transition to electronic health records (EHRs) has brought many benefits to emergency care but imposes a significant burden on staff to enter data. Poor usability has a direct consequence and opportunity cost in staff time and resources that could otherwise be employed in patient care. This research...

Registration Year

  • 2021

Resource Types

  • Dataset


  • Queen Mary University of London
  • Medical University of South Carolina
  • University of Rennes 1
  • Qassim University
  • University of Leeds
  • Bacha Khan University
  • Macau University of Science and Technology
  • National Cancer Institute
  • University of Haripur
  • Max Planck Institute for Psycholinguistics