11 Works

Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR

Xueqiang Guo, Wei Jin, Cuifang Chang, Yi Ding, Yahao Wang, Lifei Li, Yanhui Chen, Jingbo Zhang, Cunshuan Xu, Guangwen Chen & Jianlin Guo
Researchers have been exploring the genetic mechanisms underlying the control of liver regeneration (LR). However, an integrated analysis of circRNAs expression of rat regenerating livers during the proliferation phase has not been performed yet. For this purpose, circRNAs expression profile was globally analyzed by high-throughput sequencing. It showed that 10,003 circRNAs were detected, and 164 circRNAs were differentially expressed. Subsequently, 27 circRNAs were predicted to bind to 58 candidate miRNAs and compete for miRNA-binding sites...

Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR

Xueqiang Guo, Wei Jin, Cuifang Chang, Yi Ding, Yahao Wang, Lifei Li, Yanhui Chen, Jingbo Zhang, Cunshuan Xu, Guangwen Chen & Jianlin Guo
Researchers have been exploring the genetic mechanisms underlying the control of liver regeneration (LR). However, an integrated analysis of circRNAs expression of rat regenerating livers during the proliferation phase has not been performed yet. For this purpose, circRNAs expression profile was globally analyzed by high-throughput sequencing. It showed that 10,003 circRNAs were detected, and 164 circRNAs were differentially expressed. Subsequently, 27 circRNAs were predicted to bind to 58 candidate miRNAs and compete for miRNA-binding sites...

Data from: Quantifying water requirements of African ungulates through a combination of functional traits

Michiel Veldhuis, Emilian Kihwele, Victor Mchomvu, Norman Owen-Smith, Robyn Hetem, Matthew Hutchinson, Arjun Potter & Han Olff
Climate and land use change modify surface water availability in African savannas. Surface water is a key resource for both wildlife and livestock and its spatial and temporal distribution is important for understanding the composition of large herbivore assemblages in savannas. Yet, the extent to which ungulate species differ in their water requirements remains poorly quantified. Here, we infer the water requirements of 48 African ungulates by combining six different functional traits related to physiological...

Antibiotic production in Streptomyces is organized by a division of labour through terminal genomic differentiation

Zheren Zhang, Chao Du, Frédérique De Barsy, Michael Liem, Apostolos Liakopoulos, Gilles P. Van Wezel, Young H. Choi, Dennis Claessen & Daniel E. Rozen
One of the hallmark behaviors of social groups is division of labour, where different group members become specialized to carry out complementary tasks. By dividing labour, cooperative groups of individuals increase their efficiency, thereby raising group fitness even if these specialized behaviors reduce the fitness of individual group members. Here we provide evidence that antibiotic production in colonies of the multicellular bacterium Streptomyces coelicolor is coordinated by a division of labour. We show that S....

Data from: Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia

Laurent M. A. Favié, Floris Groenendaal, Marcel P. H. Van Den Broek, Carin M. A. Rademaker, Timo R. De Haan, Henrica L. M. Van Straaten, Peter H. Dijk, Arno Van Heijst, Jeroen Dudink, Koen P. Dijkman, Monique Rijken, Inge A. Zonnenberg, Filip Cools, Alexandra Zecic, Johanna H. Van Der Lee, Debbie H. G. M. Nuytemans, Frank Van Bel, Toine C. G. Egberts & Alwin J. R. Huitema
Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of morphine in this population are largely unknown. The objective of this study was to describe pharmacokinetics of morphine and its metabolites morphine-3-glucuronide and morphine-6-glucuronide in encephalopathic neonates treated with therapeutic hypothermia and to develop pharmacokinetics based dosing guidelines for this population. Study design: Term and near-term encephalopathic neonates treated with therapeutic hypothermia and...

Data from: Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis

James F. Howard, Vera Bril, Ted M. Burns, Renato Mantegazza, Malgorzata Bilinska, Andrzej Szczudlik, Said Beydoun, Francisco Javier Rodriguez De Rivera Garrido, Fredrik Piehl, Mariarosa Rottoli, Philip Van Damme, Tuan Vu, Amelia Evoli, Miriam Freimer, Tahseen Mozaffar, E. Sally Ward, Torsten Dreier, Peter Ulrichts, Katrien Verschueren, Antonio Guglietta, Hans De Haard, Nicolas Leupin & Jan J. G. M. Verschuuren
Objective: To investigate safety and explore efficacy of efgartigimod (ARGX-113), an anti-neonatal Fc receptor immunoglobulin G1 Fc fragment, in patients with generalized myasthenia gravis (gMG) with a history of anti-acetylcholine receptor (AChR) autoantibodies, who were on stable standard-of-care myasthenia gravis (MG) treatment. Methods: A phase 2, exploratory, randomized, double-blind, placebo-controlled, 15-center study is described. Eligible patients were randomly assigned (1:1) to receive 4 doses over a 3-week period of either 10 mg/kg IV efgartigimod or...

Data from: Testing an hypothesis of hybrid zone movement for toads in France

Isolde Van Riemsdijk, Roger K. Butlin, Ben Wielstra, Jan W. Arntzen & Isolde Riemsdijk
Hybrid zone movement may result in substantial unidirectional introgression of selectively neutral material from the local to the advancing species, leaving a genetic footprint. This genetic footprint is represented by a trail of asymmetric tails and displaced cline centres in the wake of the moving hybrid zone. A peak of admixture linkage disequilibrium is predicted to exist ahead of the centre of the moving hybrid zone. We test these predictions of the movement hypothesis in...

Data from: Are ecophysiological adaptive traits decoupled from leaf economics traits in wetlands?

Yingji Pan, Ellen Cieraad & Peter Van Bodegom
Wetland plants have developed a suite of traits, such as aerenchyma, radial oxygen loss, and leaf gas films, to adapt to wetland environment featured by e.g. a low redox potential and a lack of electron acceptors. These ecophysiological traits are critical for the survival and physiological functioning of wetland plants. Most studies on these traits typically focus on a single trait and a single or few species at the time. Next to these traits, traits...

Data from: Renal imaging in 199 Dutch patients with Birt-Hogg-Dubé syndrome: screening compliance and outcome

Paul Johannesma, Irma Van De Beek, Lawrence Rozendaal, Marianne Jonker, Simon Horenblas, Tijmen Van Der Wel, Jeroen Van Moorselaar, Hanne Meijers-Heijboer, Theo Starink, Arjan Houweling, Rinze Reinhard, Hans Gille, Pieter Postmus & Jan Hein Van Waesberghe
Birt-Hogg-Dubé syndrome is associated with an increased risk for renal cell carcinoma. Surveillance is recommended, but the optimal imaging method and screening interval remain to be defined. The main aim of our study was to evaluate the outcomes of RCC surveillance to get insight in the safety of annual US in these patients. Surveillance data and medical records of 199 patients with Birt-Hogg-Dubé syndrome were collected retrospectively using medical files and a questionnaire. These patients...

Data from: Global distribution patterns of mycoheterotrophy

Sofia I.F. Gomes, Peter M. Van Bodegom, Vincent S.F.T. Merckx & Nadejda A. Soudzilovskaia
Aim: Mycoheterotrophy is a mode of life where plants cheat the mycorrhizal symbiosis, receiving carbon via their fungal partners. Despite being widespread, mycoheterotrophic plants are locally rare, hampering the understanding of their global environmental drivers. Here, we explore global environmental preferences of mycoheterotrophy, and investigate environmental drivers of differential habitat preferences of mycoheterotrophic plants associated with arbuscular (AM) and ectomycorrhizal (EM) fungi. Location: Global. Time period: Current. Major taxa studied: Mycoheterotrophic flowering plants. Methods: We...

Data from: Aircraft sound exposure leads to song frequency decline and elevated aggression in wild chiffchaffs

Andrew D. Wolfenden, Hans Slabbekoorn, Karolina Kluk & Selvino De Kort
1. The ubiquitous anthropogenic low-frequency noise impedes communication by masking animal signals. To overcome this communication barrier, animals may increase the frequency, amplitude and delivery rate of their acoustic signals, making them more easily heard. However, a direct impact of intermittent, high-level aircraft noise on birds’ behaviour living close to a runway has not been studies in detail. 2. We recorded common chiffchaffs Phylloscopus collybita songs near two airports and nearby control areas, and we...

Registration Year

  • 2019
    11

Resource Types

  • Dataset
    11

Affiliations

  • Leiden University
    11
  • Fudan University Shanghai Cancer Center
    2
  • Wenzhou Medical University
    2
  • Sichuan University
    2
  • Fudan University
    2
  • Nanfang Hospital
    2
  • Beijing Institute of Technology
    2
  • University Medical Center Hamburg-Eppendorf
    2
  • Shanghai Jiao Tong University
    2
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    2