Data from: Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome

Nathan P. McNulty, Wu Meng, Alison R. Erickson, Chongle Pan, Brian K. Erickson, Eric C. Martens, Nicholas A. Pudlo, Brian D. Muegge, Bernard Henrissat, Robert L. Hettich, Jeffrey I. Gordon & Meng Wu
The human gut microbiota is an important metabolic organ. However, little is known about how its individual species interact, establish dominant positions, and respond to changes in environmental factors such as diet. In the current study, gnotobiotic mice colonized with a simplified model microbiota composed of 12 sequenced human gut bacterial species were fed oscillating diets of disparate composition. Rapid, reproducible and reversible changes in community structure were observed. Time series microbial RNA-Seq analyses revealed...

Registration Year

  • 2013
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Resource Types

  • Dataset
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Affiliations

  • Oak Ridge National Laboratory
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  • University of Tennessee at Knoxville
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  • University of Michigan Medical School
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  • French National Centre for Scientific Research
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  • Aix-Marseille University
    1
  • Washington University School of Medicine
    1