3 Works

Data from: Progressive genome-wide introgression in agricultural Campylobacter coli

Samuel K. Sheppard, Xavier Didelot, Keith A. Jolley, Aaron E. Darling, David J. Kelly, Alison Cody, Frances M. Colles, Norval J.C. Strachan, Iain D. Ogden, Ken Forbes, Nigel P. French, Philip Carter, William G. Miller, Noel D. McCarthy, Robert Owen, Eva Litrup, Michael Egholm, Stephen D. Bentley, Julian Parkhill, Martin C. J. Maiden, Daniel Falush, Jason P. Affourtit, Norval J. C. Strachan, Ben Pascoe & Guillaume Meric
Hybridization between distantly related organisms can facilitate rapid adaptation to novel environments, but is potentially constrained by epistatic fitness interactions among cell components. The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other by around 15% at the nucleotide level, corresponding to an average of nearly 40 amino acids per protein-coding gene. Using whole genome sequencing, we show that a single C. coli lineage, which has successfully colonized an agricultural niche, has been...

Data from: Weekend admission as an independent predictor of mortality: an analysis of Scottish hospital admissions

Adam E. Handel, Sunil V. Patel, Andrew Skingsley, Katrina Bramley, Roma Sobieski & Sreeram V. Ramagopalan
OBJECTIVES: Weekend admissions have been shown to be associated with an increased risk of mortality compared with weekday admissions for many diagnoses. We analysed emergency department admissions within the Scottish National Health Service to investigate whether mortality is increased in case of weekend emergency department admissions. DESIGN: A cohort study. SETTING: Scotland National Health Service (NHS) emergency departments. PARTICIPANTS: 5 271 327 emergency department admissions between 1999 and 2009. We included all patients admitted via...

Data from: Experimental design in phylogenetics: testing predictions from expected information

Diego San Mauro, David J. Gower, James A. Cotton, Rafael Zardoya, Mark Wilkinson & Tim Massingham
Taxon and character sampling is central to phylogenetic experimental design yet we lack general rules. Goldman introduced a method to construct efficient sampling designs in phylogenetics, based on the calculation of expected Fisher information given a probabilistic model of sequence evolution. The considerable potential of this approach remains largely unexplored. In an earlier study, we applied Goldman’s method to a problem in the phylogenetics of caecilian amphibians and made an a priori evaluation and testable...

Registration Year

  • 2012
    3

Resource Types

  • Dataset
    3

Affiliations

  • Wellcome Trust
    3
  • London School of Hygiene & Tropical Medicine
    1
  • University of Aberdeen
    1
  • United States Department of Agriculture
    1
  • European Bioinformatics Institute
    1
  • Museo Nacional de Ciencias Naturales
    1
  • Natural History Museum
    1
  • Statens Serum Institut
    1
  • Imperial College London
    1
  • University of London
    1