10 Works

Data from: Spatial analysis of gene regulation reveals new insights into the molecular basis of upper thermal limits

Marina Telonis-Scott, Allanah S. Clemson, Travis K. Johnson, Carla M. Sgrò & Allannah S. Clemson
The cellular stress response has long been the primary model for studying the molecular basis of thermal adaptation, yet the link between gene expression, RNA metabolism and physiological responses to thermal stress remains largely unexplored. We address this by comparing the transcriptional and physiological responses of three geographically distinct populations of D. melanogaster from eastern Australia in response to, and recovery from, a severe heat stress with and without a pre-stress hardening treatment. We focus...

Data from: A meta-analysis of the strength and nature of cytoplasmic genetic effects

Ralph Dobler, Björn Rogell, Françoise Budar & Damian K. Dowling
Genetic variation in cytoplasmic genomes (i.e. the mitochondrial genome in animals, and the combined mitochondrial and chloroplast genomes in plants) was traditionally assumed to accumulate under a neutral equilibrium model. This view has, however, come under increasing challenge from studies that have experimentally linked cytoplasmic genetic effects to the expression of life history phenotypes. Such results suggest that genetic variance located within the cytoplasm might be of evolutionary importance and potentially involved in shaping population...

Data from: Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse

Tia DiTommaso, Lynelle K. Jones, Denny L. Cottle, The WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E. Vancollie, Fiona M. Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P. Steel, John P. Sundberg, Jacqueline K. White, Ian Smyth & Ian M. Smyth
The skin is a highly regenerative organ which plays critical roles in protecting the body and sensing its environment. Consequently, morbidity and mortality associated with skin defects represent a significant health issue. To identify genes important in skin development and homeostasis, we have applied a high throughput, multi-parameter phenotype screen to the conditional targeted mutant mice generated by the Wellcome Trust Sanger Institute's Mouse Genetics Project (Sanger-MGP). A total of 562 different mouse lines were...

Data from: The genetic covariance between life-cycle stages separated by metamorphosis.

J. David Aguirre, Mark W. Blows & Dustin J. Marshall
Metamorphosis is common in animals, yet the genetic associations between life cycle stages are poorly understood. Given the radical changes that occur at metamorphosis, selection may differ before and after metamorphosis, and the extent that genetic associations between pre- and post-metamorphic traits constrain evolutionary change is a subject of considerable interest. In some instances, metamorphosis may allow the genetic decoupling of life cycle stages, whereas in others, metamorphosis could allow complementary responses to selection across...

Data from: A Drosophila laboratory evolution experiment points to low evolutionary potential under increased temperatures likely to be experienced in the future

Mads F. Schou, Torsten N. Kristensen, Vanessa Kellermann, Christian Schlötterer & Volker Loeschcke
The ability to respond evolutionarily to increasing temperatures is important for survival of ectotherms in a changing climate. Recent studies suggest that upper thermal limits may be evolutionary constrained. We address this hypothesis in a laboratory evolution experiment, encompassing ecologically relevant thermal regimes. To examine the potential for species to respond to climate change, we exposed replicate populations of Drosophila melanogaster to increasing temperatures (0.3 °C every generation) for 20 generations, whereas corresponding replicate control...

Data from: Background matching ability and the maintenance of a colour polymorphism in the red devil cichlid

William Sowersby, Topi K. Lehtonen, Bob B.M. Wong & B. B. M. Wong
The evolution and maintenance of colour polymorphisms remains a topic of considerable research interest. One key mechanism thought to contribute to the coexistence of different colour morphs is a bias in how conspicuous they are to visual predators. Although individuals of many species camouflage themselves against their background to avoid predation, differently coloured individuals within a species may vary in their capacity to do so. However, to date, very few studies have explicitly investigated the...

Data from: Transgenerational interactions involving parental age and immune status affect female reproductive success in Drosophila melanogaster

Magdalena Nystrand & Damian K. Dowling
It is well established that the parental phenotype can influence offspring phenotypic expression, independent of the effects of the offspring's own genotype. Nonetheless, the evolutionary implications of such parental effects remain unclear, partly because previous studies have generally overlooked the potential for interactions between parental sources of non-genetic variance to influence patterns of offspring phenotypic expression. We tested for such interactions, subjecting male and female Drosophila melanogaster of two different age classes to an immune...

Data from: Is adaptation to climate change really constrained in niche specialists?

Carla M. Sgró & Belinda Van Heerwaarden
Species with restricted distributions make up the vast majority of biodiversity. Recent evidence suggests that Drosophila species with restricted tropical distributions lack genetic variation in the key trait of desiccation resistance. It has therefore been predicted that tropically restricted species will be limited in their evolutionary response to future climatic changes and will face higher risks of extinction. However, these assessments have been made using extreme levels of desiccation stress (less than 10% relative humidity...

Data from: Conservation and divergence of gene expression plasticity following c. 140 million years of evolution in lodgepole pine (Pinus contorta) and interior spruce (Picea glauca × Picea engelmannii)

Sam Yeaman, Kathryn A. Hodgins, Haktan Suren, Kristin A. Nurkowski, Jason A. Holliday, Loren H. Rieseberg & Sally N. Aitken
Species respond to environmental stress through a combination of genetic adaptation and phenotypic plasticity, both of which may be important for survival in the face of climatic change. By characterizing the molecular basis of plastic responses and comparing patterns among species, it is possible to identify how such traits evolve. Here, we use de novo transcriptome assembly and RNA-seq to explore how patterns of gene expression differ in response to temperature, moisture, and light regime...

Data from: Dose-dependent effects of an immune challenge at both ultimate and proximate levels in Drosophila melanogaster

Magdalena Nystrand & Damian K. Dowling
Immune responses are highly dynamic. The magnitude and efficiency of an immune response to a pathogen can change markedly across individuals, and such changes may be influenced by variance in a range of intrinsic (e.g. age, genotype, sex) and external (e.g. abiotic stress, pathogen identity, strain) factors. Life history theory predicts that up-regulation of the immune system will come at a physiological cost, and studies have confirmed that increased investment in immunity can reduce reproductive...

Registration Year

  • 2014

Resource Types

  • Dataset


  • Monash University
  • University of Queensland
  • Aarhus University
  • University of Veterinary Medicine Vienna
  • Jackson Laboratory
  • King's College London
  • Wellcome Trust
  • AgroParisTech
  • Virginia Tech
  • University of Tübingen