Cellular dialogues that enable self-organization of dynamic spatial patterns

Yiteng Dang, Douwe A.J. Grundel & Hyun Youk
Cells form spatial patterns by coordinating their gene expressions. How a group of mesoscopic numbers (hundreds-to-thousands) of cells, without pre-defined morphogens and spatial organization, self-organizes spatial patterns remains incompletely understood. Of particular importance are dynamic spatial patterns - such as spiral waves that perpetually move and transmit information over macroscopic length-scales. We developed an open-source, expandable software that can simulate a field of cells communicating with any number of cell-secreted molecules in any manner. With...

Registration Year

  • 2019
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Resource Types

  • Dataset
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Affiliations

  • Delft University of Technology
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