183 Works

Data from: Female cowbirds have more accurate spatial memory than males

Mélanie F. Guigueno, Danielle A. Snow, Scott A. MacDougall-Shackleton & David F. Sherry
Brown-headed cowbirds (Molothrus ater) are obligate brood parasites. Only females search for host nests and they find host nests one or more days before placing eggs in them. Past work has shown that females have a larger hippocampus than males, but sex differences in spatial cognition have not been extensively investigated. We tested cowbirds for sex and seasonal differences in spatial memory on a foraging task with an ecologically relevant retention interval. Birds were trained...

Data from: The effects of dietary macronutrients on flight ability, energetics, and fuel metabolism of yellow-rumped warblers Setophaga coronata

Christopher G. Guglielmo, Alexander R. Gerson, Edwin R. Price & Quentin R. Hays
The catabolism of protein from organs and muscles during migratory flight is necessary to produce glucose, key metabolic intermediates, and water, but may have negative effects on flight range and refueling at stopovers. We tested the hypothesis, suggested by previous studies, that birds that eat high-protein insect diets use more protein for fuel in flight than those that eat high-carbohydrate fruits. First, we fed migratory yellow-rumped warblers synthetic fruit or mixed insect/fruit diets, and measured...

Data from: An increase in immature β-cells lacking Glut2 precedes the expansion of β-cell mass in the pregnant mouse

Christine A. Beamish, Linhao Zhang, Sandra K. Szlapinski, Brenda J. Strutt & David J. Hill
A compensatory increase in β-cell mass occurs during pregnancy to counter the associated insulin resistance, and a failure in adaptation is thought to contribute to gestational diabetes. Insulin-expressing but glucose-transporter-2-low (Ins+Glut2LO) progenitor cells are present in mouse and human pancreas, being predominantly located in extra-islet β-cell clusters, and contribute to the regeneration of the endocrine pancreas following induced ablation. We therefore sought to investigate the contribution of Ins+Glut2LO cells to β-cell mass expansion during pregnancy....

Supplementary Documentation - Epilepsy risk among survivors of intensive care unit hospitalization for sepsis

Tresah Antaya, Britney Allen, Lucie Richard, Salimah Shariff, Gustavo Saposnik & Jorge Burneo
Objective Our objectives were to determine if survivors of intensive care unit (ICU) hospitalizations with sepsis experience higher epilepsy risk than survivors of ICU hospitalizations without sepsis, and to identify sepsis survivors at highest risk. Methods We used linked, administrative healthcare databases to conduct a population-based, retrospective matched cohort study of adult Ontario residents discharged from an ICU between January 1, 2010 and December 31, 2015, identified using the Discharge Abstract Database. We used propensity...

BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains

Xiaoli Wu, Yanrong Zheng, Mengru Liu, Yue Li, Shijia Ma, Weidong Tang, Wenping Yan, Ming Cao, Wanqing Zheng, Lei Jiang, Jiaying Wu, Feng Han, Zhenghong Qin, Liang Fang, Weiwei Hu, Zhong Chen & Xiangnan Zhang
Mitophagy, the elimination of damaged mitochondria through autophagy, promotes neuronal survival in cerebral ischemia. Previous studies found deficient mitophagy in ischemic neurons, but the mechanisms are still largely unknown. We determined that BNIP3L/NIX, a mitophagy receptor, was degraded by proteasomes, which led to mitophagy deficiency in both ischemic neurons and brains. BNIP3L exists as a monomer and homodimer in mammalian cells, but the effects of homodimer and monomer on mitophagy are unclear. Site-specific mutations in...

Data from: Complex interactions between temperature, sexual signals, and mate choice in a desert-dwelling jumping spider

Erin Brandt, Malcolm Rosenthal & Damian Elias
Environmental context is a crucial factor that influences sexual communication systems. Particularly in ectotherms, which cannot metabolically regulate their body temperature, temperature has an outsized effect on these intraspecific interactions. Using a desert-dwelling jumping spider Habronattus clypeatus, we assessed how temperature impacts various parts of the male signal and female mate choice for the signal. These spiders have multimodal, temporally-structured courtship displays that begin with visual-only “sidling” displays and proceed to multimodal visual and vibratory...

Responses of White-throated sparrows to simulated winter storm cues

Scott MacDougall-Shackleton & Andrea Boyer
These data were used in the publication "Increased frequency of exposure to simulated winter storm cues negatively affects white-throated sparrows (Zonotrichia albicollis)" Front. Ecol. Evol. | doi: 10.3389/fevo.2020.00222 Climate change is causing changes in weather patterns and more frequent extreme weather events. Although birds are often able to cope with and respond to inclement weather with physiological and behavioral responses, as weather events become more severe or frequent the adaptive coping responses of many species...

Integrating efficacy and safety of vedolizumab compared with other advanced therapies to assess net clinical benefit of ulcerative colitis treatments: a network meta-analysis

Vipul Jairath, Keith Chan, Karen Lasch, Sam Keeping, Christian Agboton, Aimee Blake & Haridarshan Patel
Objectives: Because only one head-to-head randomized trial of biologics for moderate-to-severe UC has been performed, indirect treatment comparisons remain important. This systematic review and network meta-analysis examined efficacy and safety of biologics and tofacitinib for moderate-to-severe UC, using vedolizumab as reference. Methods: Relevant studies (N = 19) of vedolizumab, adalimumab, infliximab, golimumab, ustekinumab, and tofacitinib were identified. Study design differences were addressed by assessing efficacy outcomes conditional on response at maintenance initiation. Primary analysis used...

Data from: Seasonal shifts in the insect gut microbiome are concurrent with changes in cold tolerance and immunity

Laura V. Ferguson, Pranav Dhakal, Jacqueline E. Lebenzon, David E. Heinrichs, Carol Bucking & Brent J. Sinclair
1. Seasonal changes in the environment, such as varying temperature, have the potential to change the functional relationship between ectothermic animals, such as insects, and their microbiomes. Our objectives were to determine: a) whether seasonal changes in temperature shift the composition of the insect gut microbiome, and b) if changes in the microbiome are concomitant with changes in the physiology of the host, including the immune system and response to cold. 2. We exposed laboratory...

Data from: Purifying selection in the toll-like receptors of song sparrows Melospiza melodia

Martha J. Nelson-Flower, Ryan R. Germain, Elizabeth A. MacDougall-Shackleton, Sabrina S. Taylor & Peter Arcese
Variation in immune gene sequences is known to influence resistance to infectious diseases and parasites, and hence survival and mate choice, across animal taxa. Toll-like receptors (TLRs) comprise one essential gene family in the vertebrate innate immune system, and recognize evolutionarily conserved structures from all major microorganism classes. However, the causes and consequences of TLR variation in passerine birds remain largely unexplored. We examined seven TLR genes in song sparrows (Melospiza melodia), a species that...

Integrating efficacy and safety of vedolizumab compared with other advanced therapies to assess net clinical benefit of ulcerative colitis treatments: a network meta-analysis

Vipul Jairath, Keith Chan, Karen Lasch, Sam Keeping, Christian Agboton, Aimee Blake & Haridarshan Patel
Because only one head-to-head randomized trial of biologics for moderate-to-severe UC has been performed, indirect treatment comparisons remain important. This systematic review and network meta-analysis examined efficacy and safety of biologics and tofacitinib for moderate-to-severe UC, using vedolizumab as reference. Relevant studies (N = 19) of vedolizumab, adalimumab, infliximab, golimumab, ustekinumab, and tofacitinib were identified. Study design differences were addressed by assessing efficacy outcomes conditional on response at maintenance initiation. Primary analysis used fixed-effect models...

The role of plant-pollinator interactions in structuring nectar microbial communities

Clara De Vega, Sergio Álvarez-Pérez, Rafael G. Albaladejo, Sandy-Lynn Steenhuisen, Marc-André Lachance, Steve D. Johnson & Carlos M. Herrera
1. Floral nectar harbours a diverse microbiome of yeasts and bacteria that depend predominantly on animal visitors for their dispersal. Since pollinators visit specific sets of flowers and carry their own unique microbiota, we hypothesize that plant species visited by the same set of pollinators may support non-random nectar microbial communities linked together by the type of pollinator. 2. Here we explore the importance of plant-pollinator interactions in the assembly of nectar microbiome and study...

Data from: Toxic diffuse isolated cerebellar edema from over-the-counter health supplements

David Dongkyung Kim, Christen L. Shoesmith & Lee-Cyn Ang
Figure e-1. Pathology images of the cerebellar biopsy sample.(Panel A) Biopsy shows cerebellar cortex with dark Purkinje neurons and Purkinje neuron dropout. There is microvacuolation of neuropil and white matter. Features are consistent with ischemic neuronal changes with surrounding edema. Luxol-fast blue/hematoxylin-eosin (Bar = 50 microns). (Panel B) Neurofilament immunohistochemistry highlights collapsed basket cells which emphasize the Purkinje neuron dropout. (Bar = 50 microns).Supplementary Figure.tifTable e-1. Labelled ingredients of each herbal or naturopathic product that...

Data from: Range-wide populations of a long-distance migratory songbird converge during stopover in the tropics

Camila Gomez, Sara L. Guerrero, Alyssa M. FitzGerald, Nicholas J. Bayly, Keith A. Hobson & Carlos Daniel Cadena
Geographic convergence during migration influences the extent to which animal populations may experience carry-over effects across periods of the annual cycle. When most individuals of a population share geographic areas during a given period, carry-over effects are likely stronger than when individuals occupy multiple areas. We used genetic data and stable isotope (δ2H) measurements from feathers and claws to describe the likely breeding and wintering geographic origins of a long-distance migratory songbird (Gray-cheeked Thrush, Catharus...

Data from: Molecular diet analysis finds an insectivorous desert bat community dominated by resource sharing despite diverse echolocation and foraging strategies

Rowena Gordon, Sally Ivens, Loren K. Ammerman, M. Brock Fenton, Joanne E. Littlefair, John M. Ratcliffe & Elizabeth L. Clare
Interspecific differences in traits can alter the relative niche use of species within the same environment. Bats provide an excellent model to study niche use because they have a wide variety of behavioural, acoustic and morphological traits that may lead to multi-species, functional groups. Predatory bats have been classified by their foraging location (edge, clutter, open space), ability to aerial hawk and/or substrate glean prey and echolocation call design and flexibility, all of which may...

Data files for: Hazardous loss of genetic diversity through selective sweeps in asexual populations

Lindi Wahl & Mark Tanaka
With the two-fold cost of sex, derived asexual organisms have an immediate reproductive advantage over their sexual sisters. Yet the "twiggy'' phylogenetic distribution of asexual lineages implies that they go extinct relatively quickly over evolutionary time. Meanwhile, bacteria and archaea have persisted for billions of years without requiring sexual reproduction. A simple explanation for this difference is that prokaryotes have very large population sizes that are not subject to the accumulation of deleterious mutations, but...

Invasive widow spiders perform differently at low temperatures than conspecifics from the native range

Monica A. Mowery, Susan E. Anthony, Alexandra N. Dorison, Andrew C. Mason & Maydianne C. B. Andrade
Temperature challenges are one of the leading abiotic causes of success or failure of non-native species in a novel environment, and this is particularly true for low temperatures. Establishing and reproducing in a novel thermal environment can alter survival, behaviour, and traits related to fitness. It has been proposed that plasticity or adaptation of thermal tolerance may allow an introduced species to thrive, or that successful invaders may be those with a thermal breadth in...

Hierarchy of fear: experimentally testing ungulate reactions to lion, African wild dog and cheetah

Liana Zanette, Noa Rigoudy, Michael Clinchy, Mike Peel, Sarah Huebner & Craig Packer
Experiments have begun demonstrating that the fear (antipredator responses) large carnivores inspire in ungulates can shape ecosystem structure and function. Most such experiments have focused on the impacts of either just one large carnivore, or all as a whole, rather than the different impacts different large carnivores may have in intact multi-predator-prey systems. Experimentally testing the relative fearfulness ungulates demonstrate toward different large carnivores is a necessary first step in addressing these likely differing impacts....

Additional file 9 of Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Additional file 9: Table S4. The 21 prognositc DE-MRGs based on the TCGA GBM cohort.

Additional file 10 of Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Additional file 10: Table S5. GO enrichment analysis by using DAVID.

Additional file 13 of Comparative transcriptomic analysis provides insights into the molecular basis underlying pre-harvest sprouting in rice

Dong Liu, Mingyang Zeng, Yan Wu, Yanli Du, Jianming Liu, Shaoqiang Luo & Yongjun Zeng
Additional file 13: Table S12. The list of representative DEGs related to phenylpropanoid biosynthesis.

Additional file 15 of Comparative transcriptomic analysis provides insights into the molecular basis underlying pre-harvest sprouting in rice

Dong Liu, Mingyang Zeng, Yan Wu, Yanli Du, Jianming Liu, Shaoqiang Luo & Yongjun Zeng
Additional file 15: Table S14. Primers used for quantitative real-time PCR in this study.

Additional file 15 of Comparative transcriptomic analysis provides insights into the molecular basis underlying pre-harvest sprouting in rice

Dong Liu, Mingyang Zeng, Yan Wu, Yanli Du, Jianming Liu, Shaoqiang Luo & Yongjun Zeng
Additional file 15: Table S14. Primers used for quantitative real-time PCR in this study.

LINC02535/miR-30a-5p/GALNT3 axis contributes to lung adenocarcinoma progression via the NF- κ B signaling pathway

Yue Li, Jian Zhao, Weijie Zhang, Anqi Wang, Min Jiao, Xin Cai, Jianjie Zhu, Zeyi Liu & Jian-an Huang
Long non-coding RNAs (LncRNA) play important roles in multiple types of cancers. We addressed the role of LINC02535 by regulating the miR-30a-5p /GalNAc Transferase 3 (GALNT3) axis to promote the proliferation, migration, and invasion in lung adenocarcinoma (LUAD) cells. The Cancer Genome Atlas (TCGA) database screened differentially expressed lncRNAs. Quantitative real-time PCR analysis (qRT-PCR) confirmed that LINC02535 is highly expressed in LUAD tissues and cells. In vitro experiments showed that LINC02535 promotes the proliferation, migration,...

Registration Year

  • 2023
    16
  • 2022
    60
  • 2021
    19
  • 2020
    18
  • 2019
    8
  • 2018
    10
  • 2017
    12
  • 2016
    9
  • 2015
    8
  • 2014
    10

Resource Types

  • Dataset
    183

Affiliations

  • Western University
    183
  • Soochow University
    42
  • Jiangxi Agricultural University
    36
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    34
  • Zhejiang University
    32
  • Shanghai Jiao Tong University
    32
  • Huazhong University of Science and Technology
    30
  • Peking University
    30
  • Anhui Medical University
    30
  • Binzhou Medical College Hospital
    28