7 Works

Data from: Host plant-related genomic differentiation in the European cherry fruit fly, Rhagoletis cerasi (L., 1758) (Diptera: Tephritidae)

Vid Bakovic, Hannes Schuler, Martin Schebeck, Jeffrey L. Feder, Christian Stauffer & Gregory J. Ragland
Elucidating the mechanisms and conditions facilitating the formation of biodiversity are central topics in evolutionary biology. A growing number of studies imply that divergent ecological selection may often play a critical role in speciation by counteracting the homogenising effects of gene flow. Several examples involve phytophagous insects, where divergent selection pressures associated with host plant shifts may generate reproductive isolation, promoting speciation. Here, we use ddRADseq to assess the population structure and to test for...

A mathematical model of flow-mediated coagulation identifies factor V as a modifier of thrombin generation in hemophilia A

Michael Stobb, Kathryn Link, Matthew Sorrells, Maria Bortot, Katherine Ruegg, Marilyn Manco-Johnson, Jorge DiPaola, Suzanne Sindi, Aaron Fogelson, Karin Leiderman & Keith Neeves
Hemophilia A is a bleeding disorder categorized as severe, mild, and moderate deficiencies in factor VIII (FVIII). Within these categories the variance in bleeding severity is significant and the origins unknown. The number of parameters that could modify bleeding are so numerous that experimental approaches are not feasible for considering all possible combinations. Consequently, we turn to a mathematical model of coagulation under flow to act as a screening tool to identify parameters that are...

Data from: Fire-regime complacency and sensitivity to centennial- through millennial-scale climate change in Rocky Mountain subalpine forests, Colorado, U.S.A.

Philip E. Higuera, Christy E. Briles & Cathy Whitlock
1. Key uncertainties in anticipating future fire regimes are their sensitivity to climate change, and the degree to which climate will impact fire regimes directly, through increasing the probability of fire, versus indirectly, through changes in vegetation and landscape flammability. 2. We studied the sensitivity of subalpine forest fire regimes (i.e., fire frequency, fire severity) to previously documented climate variability over the past 6000 years, utilizing pollen and macroscopic charcoal from high-resolution lake-sediment records in...

Data from: Stage-specific genotype-by-environment interactions for cold and heat hardiness in Drosophila melanogaster.

Philip J. Freda, Zainab M. Ali, Nicholas Heter, Gregory J. Ragland & Theodore J. Morgan
Environments often vary across a life cycle, imposing fluctuating natural selection across development. Such fluctuating selection can drive evolutionary responses specific to distinct life-history stages. However, selection and genetic variation, phenotypic plasticity, and their interaction (GxE), as well as genetic correlation across development dictate stage-specific evolution. Thus, quantifying genetic covariance of fitness-related traits and plasticity across development is vital to determine whether stage-specific adaptation occurs in nature. Additionally, the interaction of genetic variation and environmental...

Migratory divides coincide with reproductive barriers across replicated avian hybrid zones above the Tibetan Plateau

Elizabeth Scordato, Chris C. R. Smith, Georgy A. Semenov, Yu Liu, Matthew R. Wilkins, Wei Liang, Alexander Rubtsov, Gomboobaatar Sundev, Kazuo Koyama, Sheela P. Turbek, Michael B. Wunder, Craig A. Stricker & Rebecca Safran
Migratory divides are proposed to be catalysts for speciation across a diversity of taxa. However, it is difficult to test the relative contributions of migratory behavior vs. other divergent traits to reproductive isolation. Comparing hybrid zones with and without migratory divides offers a rare opportunity to directly examine the contribution of divergent migratory behavior to reproductive barriers. We show that across replicate sampling transects of two pairs of barn swallow (Hirundo rustica) subspecies, strong reproductive...

Data from: A new way to estimate neurologic disease prevalence in the United States

Lorene M. Nelson, Mitchell T. Wallin, Ruth Ann Marrie, W.J. Culpepper, Annette Langer-Gould, Jon Campbell, Stephen Buka, Helen Tremlett, Gary Cutter, Wendy Kaye, Laurie Wagner & Nicholas G. Larocca
Objective: Considerable gaps exist in knowledge regarding the prevalence of neurologic diseases, such as multiple sclerosis (MS), in the United States. Therefore, the MS Prevalence Working Group sought to review and evaluate alternative methods for obtaining a scientifically valid estimate of national MS prevalence in the current health care era. Methods: We carried out a strengths, weaknesses, opportunities, and threats (SWOT) analysis for 3 approaches to estimate MS prevalence: population-based MS registries, national probability health...

Efficacy and safety of semaglutide for type 2 diabetes by race and ethnicity: a post hoc analysis of the SUSTAIN trials

Cyrus Desouza, Bertrand Cariou, Satish Garg, Nanna Lausvig, Andrea Navarria & Vivian Fonseca
Context: Variations in the prevalence and aetiology of type 2 diabetes (T2D) across race and ethnicity may affect treatment responses. Semaglutide is a glucagon-like peptide-1 (GLP-1) analog approved for once–weekly, subcutaneous (s.c.) treatment of T2D. Objective: To compare semaglutide efficacy and safety in race and ethnicity subgroups across the SUSTAIN trials. Design: Post hoc analysis of data from phase 3 randomized SUSTAIN 1–5 and 7 (pooled) and SUSTAIN 6 trials. Participants: 3,074 subjects (SUSTAIN 1–5...

Registration Year

  • 2019

Resource Types

  • Dataset


  • University of Colorado Denver
  • University of Colorado Boulder
  • University of Alabama at Birmingham
  • University of California, Merced
  • L’Institut du Cancer Courlancy Reims
  • University of Nebraska Medical Center
  • Stanford University School of Medicine
  • Free University of Bozen-Bolzano
  • Queen Mary University of London
  • University of Manitoba