Intraviral protein–protein interactions are crucial for replication, pathogenicity, and viral assembly. Among these, virus assembly is a critical step as it regulates the arrangements of viral structural proteins and helps in the encapsulation of genomic material. SARS-CoV-2 structural proteins play an essential role in the self-rearrangement, RNA encapsulation, and mature virus particle formation. In SARS-CoV, the membrane protein interacts with the envelope and spike protein in Endoplasmic Reticulum Golgi Intermediate Complex (ERGIC) to form an...

Peste des petits ruminants (PPR) characterized by fever, sore mouth, conjunctivitis, gastroenteritis, and pneumonia, is an acute, highly contagious viral disease of sheep and goats. The role of long non-coding RNAs (lncRNAs) in PPRV infection has not been explored to date. In this study, the transcriptome profiles of virulent Peste des petits ruminants virus (PPRV) infected goat tissues – lung and spleen were analyzed to identify the role of lncRNAs in PPRV infection. A total...

The detection of selection signatures assists in understanding domestication, evolution, and the identification of genomic regions related to adaptation and production traits in buffaloes. The emergence of high-throughput technologies like Next Generation Sequencing and SNP genotyping had expanded our ability to detect these signatures of selection. In this study, we sought to identify signatures of selection in five buffalo populations (Brazilian Murrah, Bulgarian Murrah, Indian Murrah, Nili-Ravi, and Kundi) using Axiom Buffalo 90 K Genotyping...

North-Eastern India is blessed with a vast diversity of rice genotypes with varying yielding abilities. However, the predominant strong soil acidity induced nutrient stresses from the toxicity of aluminum (Al3+) ions often causes sub-optimal rice productivity. The lack of suitable nutrient media for the screening of aluminum (Al) toxicity tolerance of rice genotypes is one of the limiting factors in Al tolerant varieties' development. Modified Magnavaca's solution has been the most recommended nutrient solution for...

Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and human-to-human transmission had major roles in the amplification of MARV outbreaks in African countries. The high fatality rate of up to 90% demands the broad study of MARV diseases (MVD) that correspond with MARV...

The detection of selection signatures assists in understanding domestication, evolution, and the identification of genomic regions related to adaptation and production traits in buffaloes. The emergence of high-throughput technologies like Next Generation Sequencing and SNP genotyping had expanded our ability to detect these signatures of selection. In this study, we sought to identify signatures of selection in five buffalo populations (Brazilian Murrah, Bulgarian Murrah, Indian Murrah, Nili-Ravi, and Kundi) using Axiom Buffalo 90 K Genotyping...

The present study highlights the long-term variations in temperature and precipitation using time series datasets of CRU and ERA5-Land across the Himalayan region. The Mann-Kendall and Sen’s slope-based trend analysis exhibited an apparent warming trend in the region, with higher increase in Tmin (1.5 °C) and comparatively lower increase in Tmax (0.8 °C) during 1901–2018. The joint CCl/WCRP/JCOMM based 19 extreme indices elucidated an increasing frequency of warm days (16%) in Central Himalayan urban agglomerations...

Malaria in Pregnancy (MiP) leading to morbidity and mortality is a major public health problem that poses significant risk to pregnant women and their fetus. To cope with this alarming situation, administration of Sulfadoxine-pyrimethamine (SP) drugs to pregnant women as an intermittent preventive treatment (IPT) from 16 weeks of gestation is recommended by the World Health Organization (WHO) guidelines. We conducted a comprehensive search of published articles related to MiP in last 10 years with...

Peste des petits ruminants (PPR) characterized by fever, sore mouth, conjunctivitis, gastroenteritis, and pneumonia, is an acute, highly contagious viral disease of sheep and goats. The role of long non-coding RNAs (lncRNAs) in PPRV infection has not been explored to date. In this study, the transcriptome profiles of virulent Peste des petits ruminants virus (PPRV) infected goat tissues – lung and spleen were analyzed to identify the role of lncRNAs in PPRV infection. A total...

Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and human-to-human transmission had major roles in the amplification of MARV outbreaks in African countries. The high fatality rate of up to 90% demands the broad study of MARV diseases (MVD) that correspond with MARV...

The present study highlights the long-term variations in temperature and precipitation using time series datasets of CRU and ERA5-Land across the Himalayan region. The Mann-Kendall and Sen’s slope-based trend analysis exhibited an apparent warming trend in the region, with higher increase in Tmin (1.5 °C) and comparatively lower increase in Tmax (0.8 °C) during 1901–2018. The joint CCl/WCRP/JCOMM based 19 extreme indices elucidated an increasing frequency of warm days (16%) in Central Himalayan urban agglomerations...

Despite the effective control of Bovine Tuberculosis (bTB) in many countries using test-and-slaughter, more than 50 million cattle are still likely to be infected worldwide, highlighting the urgent need for alternative interventions such as vaccines to reduce disease burden and control spread of bTB. Vaccination may be particularly important in regions where the disease is endemic, and test-and-slaughter is neither practical nor acceptable socio-economically. Bacillus Calmette-Guérin (BCG) has been in experimental use in cattle for...

More than 50 million cattle are likely exposed to bovine tuberculosis (bTB) worldwide, highlighting a need for vaccination in regions where bTB is endemic and test-and-slaughter approaches are unfeasible. Bacillus Calmette-Guérin (BCG) was first evaluated as a vaccine in cattle even before its widespread use in humans, yet its efficacy in cattle remains poorly understood. We performed a systematic review and meta-analysis on the efficacy of BCG against bTB challenge in cattle, which demonstrated a...

Intraviral protein–protein interactions are crucial for replication, pathogenicity, and viral assembly. Among these, virus assembly is a critical step as it regulates the arrangements of viral structural proteins and helps in the encapsulation of genomic material. SARS-CoV-2 structural proteins play an essential role in the self-rearrangement, RNA encapsulation, and mature virus particle formation. In SARS-CoV, the membrane protein interacts with the envelope and spike protein in Endoplasmic Reticulum Golgi Intermediate Complex (ERGIC) to form an...

Malaria in Pregnancy (MiP) leading to morbidity and mortality is a major public health problem that poses significant risk to pregnant women and their fetus. To cope with this alarming situation, administration of Sulfadoxine-pyrimethamine (SP) drugs to pregnant women as an intermittent preventive treatment (IPT) from 16 weeks of gestation is recommended by the World Health Organization (WHO) guidelines. We conducted a comprehensive search of published articles related to MiP in last 10 years with...

Additional file 1.

This systematic review evaluates the gut microbiota (GM) status in tuberculosis (TB) patients compared to healthy volunteers due to the disease or its treatment. We conducted a systematic review of all articles published in PubMed, Web of Science, and Embase that assessed the impact of TB disease and anti-tubercular therapy (ATT) on GM from inception till January 2022 (Protocol registration number in PROSPERO: CRD42021261884). Regarding the microbial diversity indices and taxonomy, we found a significant...

This systematic review evaluates the gut microbiota (GM) status in tuberculosis (TB) patients compared to healthy volunteers due to the disease or its treatment. We conducted a systematic review of all articles published in PubMed, Web of Science, and Embase that assessed the impact of TB disease and anti-tubercular therapy (ATT) on GM from inception till January 2022 (Protocol registration number in PROSPERO: CRD42021261884). Regarding the microbial diversity indices and taxonomy, we found a significant...

Additional file 1.

North-Eastern India is blessed with a vast diversity of rice genotypes with varying yielding abilities. However, the predominant strong soil acidity induced nutrient stresses from the toxicity of aluminum (Al3+) ions often causes sub-optimal rice productivity. The lack of suitable nutrient media for the screening of aluminum (Al) toxicity tolerance of rice genotypes is one of the limiting factors in Al tolerant varieties' development. Modified Magnavaca's solution has been the most recommended nutrient solution for...