3 Works

Collision between biological process and statistical analysis revealed by mean-centering

David Westneat, Yimen Araya-Ajoy, Hassen Allegue, Barbara Class, Niels Dingemanse, Ned Dochtermann, Laszlo Garamszegi, Julien Martin, Shinichi Nakagawa, Denis Reale & Holger Schielzeth
1. Animal ecologists often collect hierarchically-structured data and analyze these with linear mixed-effects models. Specific complications arise when the effect sizes of covariates vary on multiple levels (e.g., within vs among subjects). Mean-centering of covariates within subjects offers a useful approach in such situations, but is not without problems. 2. A statistical model represents a hypothesis about the underlying biological process. Mean-centering within clusters assumes that the lower level responses (e.g. within subjects) depend on...

Source data for: Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

Veronica Egger, Vanessa Lage-Rupprecht, Li Zhou, Gaia Bianchini, S. Sara Aghvami, Balazs Rozsa, Marco Sassoe-Pognetto & Max Mueller
In the rodent olfactory bulb the smooth dendrites of the principal glutamatergic mitral cells (MCs) form reciprocal dendrodendritic synapses with large spines on GABAergic granule cells (GC), where unitary release of glutamate can trigger postsynaptic local activation of voltage-gated Na+-channels (Navs), i.e. a spine spike. Can such single MC input evoke reciprocal release? We find that unitary-like activation via two-photon uncaging of glutamate causes GC spines to release GABA both synchronously and asynchronously onto MC...

Sphaerospora molnari (Myxozoa) SMBS transcriptome data

Ashlie Hartigan, Anush Kosakyan, Hana Pecková, Edit Eszterbauer & Astrid Holzer
Parasites employ proteases to evade host immune systems, feed and replicate and are often the target of anti-parasite strategies to disrupt these interactions. Myxozoans are obligate cnidarian parasites, alternating between invertebrate and fish hosts. They are highly divergent from other metazoans with regard to their gene sequences, and available genomic and transcriptomic datasets are limited. Some myxozoans are important aquaculture pathogens such as Sphaerospora molnari replicating in the blood of farmed carp before reaching the...

Registration Year

  • 2020
    3

Resource Types

  • Dataset
    3

Affiliations

  • Hungarian Academy of Sciences
    3
  • University of Quebec at Montreal
    1
  • Fraunhofer Institute for Algorithms and Scientific Computing
    1
  • University of the Sunshine Coast
    1
  • Institute of Parasitology
    1
  • University of Regensburg
    1
  • Bielefeld University
    1
  • University of Kentucky
    1
  • University of Ottawa
    1
  • UNSW Sydney
    1