Exposure to metals increases risk for pregnancy complications. Extracellular vesicle (EV) miRNA contribute to maternal-foetal communication and are dysregulated in pregnancy complications. However, metal impacts on maternal circulating EV miRNA during pregnancy are unknown. Our objective was to investigate the impact of multiple metal exposures on EV miRNA in maternal circulation during pregnancy in the MADRES Study. Associations between urinary concentrations of nine metals and 106 EV miRNA in maternal plasma during pregnancy were investigated...

This dataset comprises zircon U-Pb data on 11 samples, each containing ~90-150 individual grains. This method was applied to sediment samples from IODP Expedition 374 Site U1521 to the Ross Sea, collected on the RV JOIDES Resolution. Shipboard biostratigraphy and magnetostratigraphy suggests the samples are mainly early Miocene in age (McKay et al., 2019). The uppermost samples do, however, include younger Plio-Pleistocene sediments. Samples were measured using an Agilent 7900 laser ablation inductively-coupled plasma mass...

Exposure to metals increases risk for pregnancy complications. Extracellular vesicle (EV) miRNA contribute to maternal-foetal communication and are dysregulated in pregnancy complications. However, metal impacts on maternal circulating EV miRNA during pregnancy are unknown. Our objective was to investigate the impact of multiple metal exposures on EV miRNA in maternal circulation during pregnancy in the MADRES Study. Associations between urinary concentrations of nine metals and 106 EV miRNA in maternal plasma during pregnancy were investigated...

A new fossil batoid (ray) Ptychotrygon rostrispatula sp. nov. is described from five exceptionally well-preserved, three-dimensional skeletal remains from the Turonian (Late Cretaceous) of Morocco. These specimens represent the first known skeletal remains for the genus Ptychotrygon and allow an almost complete description of the genus providing a new insight to its phylogenetic relations and validate its taxonomic status as a member of the Sclerorhynchoidei. Mechanical preparation of the fossil remains revealed a relatively large...

The role of climate change in the origin and diversification of early hominins is hotly debated. Most accounts of early hominin evolution link observed fluctuations in species diversity to directional shifts in climate or periods of intense climatic instability. None of these hypotheses, however, have tested whether observed diversity patterns are distorted by variation in the quality of the hominin fossil record. Here, we present a detailed examination of early hominin diversity dynamics, including both...

Taxonomic identification of fossils based on morphometric data traditionally relies on the use of standard linear models to classify such data. Machine learning and decision trees offer powerful alternative approaches to this problem but are not widely used in palaeontology. Here, we apply these techniques to published morphometric data of isolated theropod teeth in order to explore their utility in tackling taxonomic problems. We chose two published datasets consisting of 886 teeth from 14 taxa...

Background: Exposure to metals increases risk for pregnancy complications. Extracellular vesicle (EV) miRNA contribute to maternal-fetal communication and are dysregulated in pregnancy complications. However, metal impacts on maternal circulating EV miRNA during pregnancy are unknown. Our objective was to investigate the impact of multiple metal exposures on EV miRNA in maternal circulation during pregnancy in the MADRES Study. Methods: Associations between urinary concentrations of nine metals and 106 EV miRNA in maternal plasma during pregnancy...

A network of 6 Guralp 6TD and 6 Guralp ESP seismometers deployed for 20 months around the Teno and Tinguiririca Valleys in the Chilean Andes.