372 Works

Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM)

Liang Liu, Shan Xiao, Yan Wang, Zifeng Zhu, Yiyao Cao, Sen Yang, Rongkang Mai & Yong Zheng
Circular RNAs (circRNAs) are closely associated with cancer development in glioblastoma (GBM), and this study aims to explore the molecular mechanisms of a novel circular RNA circZNF652 in regulating GBM aggressiveness. The present study found that CircZNF652 and SERPINE1 were upregulated, while miR-486-5p was downregulated in GBM tissues and cell lines, and GBM patients with high expression of CircZNF652 and SERPINE1, and patients with low expression of miR-486-5p tended to have a worse prognosis. Further...

Comparison of transcriptome profiles of nucleated red blood cells in cord blood between preterm and full-term neonates

Yuanyuan Han, Ling Huang, Man Zhou, Xiaoyu Tan, Shangjin Gong, Zhaojun Zhang, Tingting Jin, Xiangdong Fang, Yankai Jia & S. W. Huang
The reactivation of fetal γ-globin expression is an effective strategy for ameliorating the clinical symptoms of β-hemoglobinopathies. However, the mechanism of globin switching, especially the roles of long non-coding RNAs (lncRNAs) in this process, remains elusive. We compared the in vivo transcriptome profiles of nucleated red blood cells (NRBCs) isolated from the umbilical cord blood of preterm and full-term newborns. We collected 75 umbilical cord blood samples and performed qPCR of the candidate genes. In...

RETRACTED ARTICLE: KIAA1429 promotes osteosarcoma progression by promoting stem cell properties and is regulated by miR-143-3p

Qicai Han, Jie Yang, Hao Yang, Chao Li, Juan Li & Yuan Cao
We, the Editors and Publisher of the journal Cell Cycle, have retracted the following article: Qicai Han, Jie Yang, Hao Yang, Chao Li, Juan Li & Yuan Cao (2020) KIAA1429 promotes osteosarcoma progression by promoting stem cell properties and is regulated by miR-143-3p, Cell Cycle, 19:10, 1172-1185, DOI: 10.1080/15384101.2020.1749465 Since publication, concerns have been raised about similarity of the data in another published article: Yang J, Han Q, Li C, Yang H, Chen X, Wang...

Prospero homeobox 1 promotes proliferation, migration, and invasion of osteosarcoma cells and its clinical significance

Dawei Liu, Ran Wang, Yuefeng Wang, Ye Wang & Liantang Wang
Osteosarcoma (OS) is the most common primary malignant bone tumor. Prospero homeobox 1 (PROX1) is a key transcription factor involved in some cancers, but the role of PROX1 in OS is unclear. This study aimed to explore the clinical and biology significance of PROX1 in OS. Fifty-four OS tissues and matched nontumor tissues were collected to explore the relationship between PROX1 expression and clinical characteristics and prognosis. qRT-PCR and immunohistochemistry were used to investigate the...

Geochronology and Sr-Nd-Pb-Hf isotopic geochemistry of middle-late Permian granitic and volcanic rocks within the eastern margin of the Khanka Massif: petrogenesis and implications for the tectonic nature

Chen-Ying Sui, Feng Wang, Wen-Liang Xu, Yi-Ni Wang, A.A. Sorokin, A.V. Grebennikov & I.V. Kemkin
The Khanka Massif forms the easternmost part of the Central Asian Orogenic Belt (CAOB) and represents an ideal location for examination of the timing and processes involved in the transition from the Palaeo-Asian to Palaeo-Pacific Ocean tectonic systems. However, it is obstructed because the late Palaeozoic tectonic attributes of the eastern margin of this massif remain unclear. In this paper, we provide zircon U-Pb ages and Hf isotopic, as well as the whole-rock Sr-Nd-Pb-Hf isotopic...

Transcriptome Analysis of Adipocytokines and Their-related LncRNAs in Lung Adenocarcinoma Revealing the Association with Prognosis, Immune Infiltration, and Metabolic Characteristics

Jie Ren, Hui Zhang, Jinna Wang, Yingsong Xu, Lei Zhao & Qihang Yuan
Lung adenocarcinoma (LUAD) is amongst the major contributors to cancer-related deaths on a global scale. Adipocytokines have an impact on immune and metabolism. Long non-coding RNAs (lncRNAs) are indispensable participants in cancer. We performed a pan-cancer analysis of the mRNA expression, single nucleotide variation, copy number variation, and prognostic value of adipocytokines, and displayed the results in heat maps. LUAD samples were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA)...

Novel H5N6 reassortants bearing the clade 2.3.4.4b HA gene of H5N8 virus have been detected in poultry and caused multiple human infections in China

Wenli Gu, Jianzhong Shi, Pengfei Cui, Cheng Yan, Yaping Zhang, Congcong Wang, Yuancheng Zhang, Xin Xing, Xianying Zeng, Liling Liu, Guobin Tian, Yasuo Suzuki, Chengjun Li, Guohua Deng & Hualan Chen
The globally circulating H5N8 avian influenza viruses bearing the clade 2.3.4.4b hemagglutinin (HA) gene are responsible for the loss of more than 33 million domestic poultry since January 2020. Moreover, the H5N8 viruses have reassorted with other avian influenza viruses and formed H5N1, H5N2, H5N3, H5N4, and H5N5 viruses in Europe, Africa, and North America. In this study, we analyzed 15 H5N6 viruses isolated from poultry and seven H5N6 viruses isolated from humans, and found...

Magnesium isoglycyrrhizinate suppresses bladder cancer progression by modulating the miR-26b/Nox4 axis

Zhihao Yuan, Guancheng Guo, Guifang Sun, Qi Li, Lihui Wang & Baoping Qiao
Magnesium isoglycyrrhizinate (MI), a magnesium salt of 18α-GA stereoisomer, has been reported to exert efficient hepatoprotective activity. However, its effect on bladder cancer remains unclear. The study explored the effects of MI on the growth, colony formation, apoptosis, invasion, and migration of bladder cancer cells (HTB9 and BIU87 cells). Typical apoptotic changes of bladder cancer cells such as nuclear concentration and fragmentation were observed using Hoechst staining. The effects of MI on the expression levels...

Transcriptome analysis of strawberry (Fragaria × ananasa) responsive to Colletotrichum gloeosporioides inoculation and mining of resistance genes

Wenwei Liang, Mingjie Wang, Binghao Du, Lei Ling, Yingdong Bi, Jinghua Zhang, Yimin Sun, Shuang Zhou, Lili Zhang, Xiao Ma, Jun Ma, Liren Wu & Changhong Guo
Strawberry has high nutritional and economic value and is an important horticultural crop widely cultivated worldwide. Strawberry anthracnose is the most harmful disease in strawberry production, which causes huge production losses every year. Mining disease resistance genes and breeding high-quality strawberry varieties are the fundamental way to solve the problem of strawberry anthracnose. In this study, transcriptome analysis and disease resistance-related genes mining were targeted on strawberry anthracnose. The main results are as follows: (1)...

Hybrid three-dimensional modelling for reservoir fluorescent dissolved organic matter risk assessment

Xinchen Wang, Hong Zhang, Edoardo Bertone, Rodney A. Stewart & Sara P. Hughes
A coupled data-driven and 3-dimensional (3D) process-based fluorescent dissolved organic matter (fDOM) prediction model was developed for a shallow, subtropical Australian reservoir. The extent to which reservoir water volume, inflow, and wind conditions affect the fDOM transport dynamics during cyclonic weather events was assessed through scenario analysis and a data-driven Bayesian network (BN) approach. The analysis shows that (a) inflow plumes are the main sources of fDOM during heavy rainfall; (b) the concentration of fDOM...

NLRC5 Restricts Dengue Virus Infection by Promoting the Autophagic Degradation of Viral NS3 through E3 Ligase CUL2 (cullin 2)

Jiawei Hao, Jinqian Li, Zhenzhen Zhang, Yang Yang, Qing Zhou, Tiantian Wu, Tongling Chen, Zhongdao Wu, Ping Zhang, Jun Cui & Yi-Ping Li
NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably suppressed DENV infection, whereas knockout of NLRC5 led to a significant increase in DENV infection. Mechanistic...

Subspace Estimation with Automatic Dimension and Variable Selection in Sufficient Dimension Reduction

Jing Zeng, Qing Mai & Xin Zhang
Sufficient dimension reduction (SDR) methods target finding lower-dimensional representations of a multivariate predictor to preserve all the information about the conditional distribution of the response given the predictor. The reduction is commonly achieved by projecting the predictor onto a low-dimensional subspace. The smallest such subspace is known as the Central Subspace (CS) and is the key parameter of interest for most SDR methods. In this article, we propose a unified and flexible framework for estimating...

SPRY4 promotes adipogenic differentiation of human mesenchymal stem cells through the MEK–ERK1/2 signaling pathway

Na Li, Yunfei Chen, Haiyan Wang, Jing Li & Robert Chunhua Zhao
Obesity is a chronic metabolic disorder characterized by the accumulation of excess fat in the body. Preventing and controlling obesity by inhibiting the adipogenic differentiation of mesenchymal stem cells (MSCs) and thereby avoiding the increase of white adipose tissue is safe and effective. Recent studies have demonstrated that Sprouty proteins (SPRYs) are involved in cell differentiation and related diseases. However, the role and mechanism of SPRY4 in MSC adipogenic differentiation remain to be explored. Here,...

Novel mycoplasma nucleomodulin MbovP475 decreased cell viability by regulating expression of CRYAB and MCF2L2

Gang Zhao, Doukun Lu, Shujuan Wang, Hui Zhang, Xifang Zhu, Zhiyu Hao, Ali Dawood, Yingyu Chen, Elise Schieck, Changmin Hu, Xi Chen, Liguo Yang & Aizhen Guo
Nucleomodulins are secreted bacterial proteins whose molecular targets are located in host cell nuclei. They are gaining attention as critical virulence factors that either modify the epigenetics of host cells or directly regulate host gene expression. Mycoplasma bovis is a major veterinary pathogen that secretes several potential virulence factors. The aim of this study was to determine whether any of their secreted proteins might function as nucleomodulins. After an initial in silico screening, the nuclear...

Additional file 6 of Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Additional file 6: Table S1. The mitochondria-related genes extracted from the uniprot database.

Additional file 8 of Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Additional file 8: Table S3. The 201 DE-MRGs between neoplatstic and non-neoplastic cells.

Additional file 1 of A CT-based nomogram for differentiating invasive fungal disease of the lung from bacterial pneumonia

Meilin Gong, Jingmei Xu, Kang Li, Ke Li, Yuwei Xia, Yang Jing, Jiafei Chen, Jing Li, Jing Yang, Mingshan Du, Wenjing Hou, Yuan Ou, Lian Li & Wei Chen
Additional file 1. On the orininal data of the study.

Additional file 5 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 5: Table S2. One-to-one orthologous relationships among T.aestivum and T.aestivum, A.thaliana, A. tauschii, B. distachyon, H. vulgare, rice, S.italica and Zea mays, respectively.

Additional file 6 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 6: Table S3. The information of cis-acting elements on the promoters of T. aestivum RING-zf genes.

Additional file 6 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 6: Table S3. The information of cis-acting elements on the promoters of T. aestivum RING-zf genes.

Additional file 2 of Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer

Peng Song, Ying Li, Feng Wang, Lingxiao Pu, Linsen Bao, Hengfei Gao, Chuandong Zhu, Meng Wang & Liang Tao
Additional file 2: Table S1. The characteristics of methylation-driven lncRNAs.

Additional file 10 of Targeted Identification of Rice Grain-Associated Gene Allelic Variation Through Mutation Induction, Targeted Sequencing, and Whole Genome Sequencing Combined with a Mixed-Samples Strategy

Kai Sun, Dandan Li, Aoyun Xia, Hua Zhao, Qin Wen, Sisi Jia, Jiafeng Wang, Guili Yang, Danhua Zhou, Cuihong Huang, Hui Wang, Zhiqiang Chen & Tao Guo
Additional file 10: Table S7. Mutation site information screened by whole genome sequencing.

Additional file 6 of Targeted Identification of Rice Grain-Associated Gene Allelic Variation Through Mutation Induction, Targeted Sequencing, and Whole Genome Sequencing Combined with a Mixed-Samples Strategy

Kai Sun, Dandan Li, Aoyun Xia, Hua Zhao, Qin Wen, Sisi Jia, Jiafeng Wang, Guili Yang, Danhua Zhou, Cuihong Huang, Hui Wang, Zhiqiang Chen & Tao Guo
Additional file 6: Table S3. Primers for authenticity verification of mutant individuals.

Additional file 7 of Targeted Identification of Rice Grain-Associated Gene Allelic Variation Through Mutation Induction, Targeted Sequencing, and Whole Genome Sequencing Combined with a Mixed-Samples Strategy

Kai Sun, Dandan Li, Aoyun Xia, Hua Zhao, Qin Wen, Sisi Jia, Jiafeng Wang, Guili Yang, Danhua Zhou, Cuihong Huang, Hui Wang, Zhiqiang Chen & Tao Guo
Additional file 7: Table S4. Grain type datas.

Additional file 10 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 10: Table S8. Gene coverage of various functional KEGG genes detected through shotgun sequencing.

Registration Year

  • 2022
    372

Resource Types

  • Dataset
    372

Affiliations

  • Tianjin Medical University
    372
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    285
  • Zhejiang University
    255
  • Shanghai Jiao Tong University
    231
  • Chinese Academy of Sciences
    214
  • Fudan University
    208
  • Sichuan University
    207
  • Sun Yat-sen University
    205
  • Southern Medical University
    189
  • Huazhong University of Science and Technology
    188