5 Works

Neurofilament light chain (NfL) as a biomarker of hereditary transthyretin-mediated amyloidosis

Paul Nioi, Simina Ticau, Gautham V. Sridharan, Shira Tsour, William L. Cantley, Amy Chan, Jason A. Gilbert, David Erbe, Emre Aldinc, Mary M. Reilly, David Adams, Michael Polydefkis, Kevin Fitzgerald & Akshay Vaishnaw
To identify changes in the proteome associated with onset and progression of ATTRv amyloidosis, we performed an observational, case-controlled study which compared proteomes of patients with ATTRv amyloidosis and healthy controls. Plasma levels of >1,000 proteins were measured in patients with ATTRv amyloidosis with polyneuropathy who received either placebo or patisiran in the APOLLO study and in healthy controls. The impact of patisiran on the time profile of each protein was determined by linear mixed...

Plant species fed on by wild ring-tailed lemurs (Lemur catta) at nine sites

Stephanie Canington
A key aspect of a primate’s ecology is its food source – the very nature of which is spatially and seasonally dependent, and may be affected by anthropic pressures. One of the most endangered, yet best-studied, strepsirrhine primates is the ring-tailed lemur (Lemur catta) – a species that has experienced significant human-induced habitat loss over many decades. To help understand feeding variability across time and space, I present a literature review of plant species (and...

Chromosomal-level genome assembly of the scimitar‐horned oryx: insights into diversity and demography of a species extinct in the wild

Emily Humble, Pavel Dobrynin, Helen Senn, Justin Chuven, Alan F. Scott, David W. Mohr, Olga Dudchenko, Arina D. Omer, Zane Colaric, Erez Lieberman Aiden, Shaikha Salem Al Dhaheri, David Wildt, Shireen Oliaji, Gaik Tamazian, Budhan Pukazhenthi, Rob Ogden & Klaus‐Peter Koepfli
Captive populations provide a valuable insurance against extinctions in the wild. However, they are also vulnerable to the negative impacts of inbreeding, selection and drift. Genetic information is therefore considered a critical aspect of conservation management. Recent developments in sequencing technologies have the potential to improve the outcomes of management programmes; however, the transfer of these approaches to applied conservation has been slow. The scimitar‐horned oryx (Oryx dammah) is a North African antelope that has...

Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes

Mari Sato, Tadataka Tsuji, Kunyan Yang, Jonathan Dreyfuss, Tian Lian Huang, Chih-Hao Wang, Farnaz Shamsi, Luiz Leiria, Matthew Lynes, Yu-Hua Tseng, Xiaozhi Ren & King-Wai Yau
Opsin3 (Opn3) is a transmembrane heptahelical G-protein-coupled receptor (GPCR) with the potential to produce a non-visual photoreceptive effect. Interestingly, anatomical profiling of GPCRs reveals that Opn3 mRNA is highly expressed in adipose tissue. The photosensitive functions of Opn3 in mammals are poorly understood, and whether Opn3 has a role in fat is entirely unknown. In this study, we found that Opn3-knockout (Opn3-KO) mice were prone to diet-induced obesity and insulin-resistance. At the cellular level, Opn3-KO...

Glucose transporter expression and regulation following a fast in the ruby-throated hummingbird, Archilochus colubris

Raafay Syed Ali, Morag F. Dick, Saad Muhammad, Dylan Sarver, Lily Hou, G. William Wong & Kenneth C. Welch
Hummingbirds, subsisting almost exclusively on nectar sugar, face extreme challenges to blood sugar regulation. The capacity for transmembrane sugar transport is mediated by the activity of facilitative glucose transporters (GLUTs) and their localisation to the plasma membrane (PM). In this study, we determined the relative protein abundance of GLUT1, GLUT2, GLUT3, and GLUT5 via immunoblot using custom antibodies in whole-tissue and PM fractions of flight-muscle, heart, and liver of ruby-throated hummingbirds (Archilochus colubris). GLUTs examined...

Registration Year

  • 2020

Resource Types

  • Dataset


  • Johns Hopkins University School of Medicine
  • Environment Agency Abu Dhabi
  • Alnylam Pharmaceuticals (United States)
  • University of Edinburgh
  • Baylor College of Medicine
  • University of Toronto
  • Harvard Medical School
  • University of Paris-Saclay
  • University of London
  • Smithsonian Conservation Biology Institute