Additional file 12 Supplementary Table 4. Expression profile for mouse KRAB-Zfps in various types and tissue types (information for Fig. 2).

Additional file 13 Supplementary Table 5. sgRNA efficiency test in reporter system (raw data for Fig. 4B and D).

Additional file 9 Supplementary Table 1. All mouse and human KRAB-ZFP genes (information for Fig. 1 A and S1A)

Additional file 3: Propagation walkscores of 127 proxy protein-coding genes in the TCGA-BRCA cohort.

Additional file 4: Canonical pathways, diseases and functions associated with the 127 proxy protein-coding genes.

Additional file 7: Akaike information criterion (AIC), delta AIC, and HRs for death (overall survival) and corresponding 95%-confidence interval for ICR and 3 ir-lncRNA signature in 18 solid cancer TCGA datasets and RAQA cohort.

Supplementary Material 2

Supplementary Material 5

Additional file 1: Supplementary figure 1. A mRNA levels of grp78 and chop in TM-stimulated BV-2 cells; B mRNA levels of inos and il-10 in TM-stimulated BV-2 cells; C mRNA levels of grp78 and chop in 4-PBA-stimulated BV-2 cells. B mRNA levels of inos and il-10 4-PBA-stimulated BV-2 cells. Supplementary figure 2. A Full-length blots/gels of β-actin; B Full-length blots/gels of PERK; C Full-length blots/gels p-PREK. All of them were repeated three times. Supplementary figure...

Additional file 4. Differentially metabolic substance data.

Additional file 4. Differentially metabolic substance data.

We investigated the role of IL-17A in sevoflurane-inducedneurocognitive impairment in neonatal mice. Seventy-two wild-type (WT) and 42 IL-17A knockout (KO) neonatal mice were randomly divided into WT (n = 36), IL-17A−/− (n = 6), sevoflurane (Sev, n = 36), and IL-17A−/− + sevoflurane (IL-17A−/− + Sev, n = 36) groups. The latter two groups were given 3% sevoflurane for 2 h per day on postnatal days (P) 6–8. Behavioral experiments were performed on P30–36. At...

The protection of the isolated heart is very important in heart transplantation surgery, meanwhile, the ischaemia/reperfusion (I/R) of the isolated heart is the main cause of its damage. A timely supply of oxygen can significantly improve the prevention of myocardial ischaemia, however, the cardioprotective solution does not have an oxygen supply function. Haemoglobin Based on Oxygen Carriers (HBOCs) is a kind of nano-oxygen drug, which can effectively and timely supply oxygen to hypoxic organs and...

The present study aimed to assess the role of the long non-coding RNA-urothelial cancer associated 1 (lncRNA-UCA1)/microRNA (miR)-383/vascular endothelial growth factor A (VEGFA) axis in regulating lung adenocarcinoma physiology through in vivo and in vitro experiments. The expression profile of lncRNA-UCA1 was analyzed by genome-wide analysis from GSE146459. The cell counting Kit-8, colony formation, wound healing and transwell assays were performed to evaluate the effects of lncRNA-UCA1 in vitro. In addition, luciferase reporter assays were...

Additional file 13 Supplementary Table 5. sgRNA efficiency test in reporter system (raw data for Fig. 4B and D).

Additional file 16 Supplementary Table 8. Fingerprints of the 216 Human KRAB-ZFPs on chr19.

Additional file 9 Supplementary Table 1. All mouse and human KRAB-ZFP genes (information for Fig. 1 A and S1A)

Additional file 1. Clinical data for HPV52 study in Taizhou area, China.

ABSTRACT Introduction The standing long jump consists of four parts: pre-swing, take-off, flying, and landing. Objective Analyze the influence of gymnastics game fitness on standing long jump. Methods Eight kindergartens in a city were selected and divided into experimental and control groups. The children in the experimental group were intervened in gymnastics and game fitness modules. Each module was intervened in a rolling cycle in the morning and afternoon outdoor activities of children from June...

Additional file 2. Differentially expressed gene data.

Additional file 3. Differentially expressed protein data.

Additional file 3: Propagation walkscores of 127 proxy protein-coding genes in the TCGA-BRCA cohort.

Additional file 7: Akaike information criterion (AIC), delta AIC, and HRs for death (overall survival) and corresponding 95%-confidence interval for ICR and 3 ir-lncRNA signature in 18 solid cancer TCGA datasets and RAQA cohort.

All source data of submitted manuscript.

By leveraging single-cell transcriptome and T cell receptor (TCR) sequencing, we aimed to track the transcriptional signatures of CAR T cell clonotypes throughout the course of treatment and furthermore identify molecular patterns leading to potent CAR T cell cytotoxicity. The data presented in this study encompass blood and bone marrow samples from patients ≤ 21 years of age with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) participating in the SJCAR19 phase I/II clinical trial...