1,073 Works

Additional file 10 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 10: Table S8. Gene coverage of various functional KEGG genes detected through shotgun sequencing.

Additional file 5 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 5: Table S4. Relative abundance of orders detected through 16S rRNA gene sequencing using fecal DNA.

Additional file 4 of Functional structure analysis and genome-wide identification of CNX gene family in cotton

Nan Xu, Hong Zhang, Yuexin Zhang, Yapeng Fan, Jing Wang, Waqar Afzal Malik, Cun Rui, Mingge Han, Xuke Lu, Xiugui Chen, Junjuan Wang, Delong Wang, Shuai Wang, Chao Chen, Lixue Guo, Lanjie Zhao & Wuwei Ye
Additional file 4. Table S4: ID and protein sequences of 60 CNXs family members in cotton.

Additional file 4 of Functional structure analysis and genome-wide identification of CNX gene family in cotton

Nan Xu, Hong Zhang, Yuexin Zhang, Yapeng Fan, Jing Wang, Waqar Afzal Malik, Cun Rui, Mingge Han, Xuke Lu, Xiugui Chen, Junjuan Wang, Delong Wang, Shuai Wang, Chao Chen, Lixue Guo, Lanjie Zhao & Wuwei Ye
Additional file 4. Table S4: ID and protein sequences of 60 CNXs family members in cotton.

Additional file 7 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 7: Table S6. Relative abundance of genera detected through 16S rRNA gene sequencing using fecal DNA.

Additional file 9 of Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet

Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian & Sookja Kim Chung
Additional file 9: Table S7. Relative abundance of bacterial species determined through shotgun sequencing.

Additional file 2 of Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions

Xinhui Liu, Jifeng Yang, Hongkai Li, Qing Wang, Yuanyuan Yu, Xiaoru Sun, Shucheng Si, Lei Hou, Lu Liu, Fan Yang, Ran Yan, Yifan Yu, Zhentao Fu, Zilong Lu, Dejin Li, Hao Xue, Xiaolei Guo, Fuzhong Xue & Xiaokang Ji
Additional file 2: Table S1. Ranked matrix of LCR in global scope and the contribution of the genetic and environmental factors on the variation in cancer risk. Table S2. Ranked matrix of LCR in national-wide of China and the contribution of the genetic and environmental factors on the variation in cancer risk. Table S3. Ranked matrix of LCR in counties of Shandong province, China and the contribution of the genetic and environmental factors on the...

Additional file 2 of Extracellular vesicles isolated from hyperuricemia patients might aggravate airway inflammation of COPD via senescence-associated pathway

Xuanqi Liu, Zheng Li, Yang Zheng, Wenhao Wang, Peiqing He, Kangwei Guan, Tao Wu, Xiaojun Wang & Xuelin Zhang
Additional file 2.

Additional file 2 of Extracellular vesicles isolated from hyperuricemia patients might aggravate airway inflammation of COPD via senescence-associated pathway

Xuanqi Liu, Zheng Li, Yang Zheng, Wenhao Wang, Peiqing He, Kangwei Guan, Tao Wu, Xiaojun Wang & Xuelin Zhang
Additional file 2.

Reconstructing the East Palaeotethyan assemblage boundary at West Indonesia: constraints from Triassic granitoids in Bangka and Belitung islands

Yuzhi Zhang, Xiaoqing Yu, Yuejun Wang, Xin Qian, Chengshi Gan, Azman Ghani, Yongqi Yu & Chang Xu
Table S1, summary of sampling locations, zircon U–Pb and in situ Hf–O analyses of the granitoids in Bangka and Belitung islands, Indonesia; Table S2, whole-rock major oxides, trace elemental and Sr–Nd–Pb isotopic data for the Triassic granitoids in Bangka and Belitung islands, Indonesia; Table S3, LA-ICP-MS zircon U–Pb data for the Triassic granitoids in Bangka and Belitung islands, Indonesia; and Table S4, zircon in situ Hf-O isotopic data for the Triassic granitoids in Bangka and...

Additional file 1 of Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Yang Liu, Wenjie Song, Haoran Liang, Chaoxin Li, Wenjie Niu, Huifeng Shao, Yuze Wang, Ziquan Yang, Pengcui Li, Xiaogang Wu, Yong He, Xiaochun Wei & Wangping Duan
Additional file 1.

Additional file 2 of Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Yang Liu, Wenjie Song, Haoran Liang, Chaoxin Li, Wenjie Niu, Huifeng Shao, Yuze Wang, Ziquan Yang, Pengcui Li, Xiaogang Wu, Yong He, Xiaochun Wei & Wangping Duan
Additional file 2.

Additional file 10 of Evolution and function of developmentally dynamic pseudogenes in mammals

Sheng Hu Qian, Lu Chen, Yu-Li Xiong & Zhen-Xia Chen
Additional file 10: Table S9. DDPs among different tissues in mouse.

Additional file 11 of Evolution and function of developmentally dynamic pseudogenes in mammals

Sheng Hu Qian, Lu Chen, Yu-Li Xiong & Zhen-Xia Chen
Additional file 11: Table S10. Expression level of human DDPs in developmental transcriptome.

Additional file 8 of Functional structure analysis and genome-wide identification of CNX gene family in cotton

Nan Xu, Hong Zhang, Yuexin Zhang, Yapeng Fan, Jing Wang, Waqar Afzal Malik, Cun Rui, Mingge Han, Xuke Lu, Xiugui Chen, Junjuan Wang, Delong Wang, Shuai Wang, Chao Chen, Lixue Guo, Lanjie Zhao & Wuwei Ye
Additional file 8. Table S8: Relative expression levels of 8 selected genes under four abiotic stresses.

Additional file 5 of ERF49 mediates brassinosteroid regulation of heat stress tolerance in Arabidopsis thaliana

Xia Chen, Huidan Xue, Liping Zhu, Huiqin Wang, Hao Long, Jun Zhao, Funing Meng, Yunfei Liu, Yuan Ye, Xiaomin Luo, Zhi Liu, Guanghui Xiao & Shengwei Zhu
Additional file 5. Detailed information of 30 overlap genes downregulated in ERF49 overexpression lines and upregulated after heat and BR treatment.

XRD数据.xlsx

Xiaoya Yan, Shougao Ni, Yueqing Xu, Yifan Xu, Xinyuan Shen & Rong Liu
This is original data.

Ligustrazine suppresses platelet aggregation through inhibiting the activities of calcium sensors

Shuibo Gao, Zhen Lei & Hong Wu
Abstract Ligustrazine is widely used for the treatment of cardiovascular diseases in traditional Chinese medication. It has been reported that Ligustrazine decreases the concentration of intracellular calcium ions (Ca2+); however, the underlying mechanism remains unknown. In the present study, the effect of Ligustrazine on adenosine diphosphate (ADP)-induced platelet aggregation was evaluated using a turbidimetric approach. The changes in concentration of intracellular Ca2+ stimulated by ADP was measured using fluo-4, a fluorescent Ca2+ indicator dye. The...

NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2)

Jiawei Hao, Jinqian Li, Zhenzhen Zhang, Yang Yang, Qing Zhou, Tiantian Wu, Tongling Chen, Zhongdao Wu, Ping Zhang, Jun Cui & Yi-Ping Li
NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that the expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably suppressed DENV infection, whereas knockout of NLRC5 led to a significant increase in DENV infection....

Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China

Canjia Zhang, Huan Chen, Shangxin Cui, Yeli Lin, Yongqiang Liang, Ping Zhao, Changyi Wang, Shan Xu, Xiaolin Peng, Hongen Chen, Li Wang, Dan Zhao, Ming Zhang, Dongsheng Hu, Yanmei Lou & Fulan Hu
This study aimed at investigating the relationships between Platelet-Lymphocyte ratio (PLR) and Neutrophil–Lymphocyte ratio (NLR) and their dynamic changes (∆PLR, ∆NLR) with type 2 diabetes mellitus (T2DM) in a Chinese cohort study. This study recruited 41,439 individuals who were diagnosed without T2DM at first health examination and completed at least one follow-up. The relationships between NLR, PLR, ∆PLR, ∆NLR and T2DM risk were analyzed using the Cox regression model with corresponding Hazard Ratios (HRs) and...

Learning Coefficient Heterogeneity over Networks: A Distributed Spanning-Tree-Based Fused-Lasso Regression

Xin Zhang, Jia Liu & Zhengyuan Zhu
Identifying the latent cluster structure based on model heterogeneity is a fundamental but challenging task arises in many machine learning applications. In this article, we study the clustered coefficient regression problem in the distributed network systems, where the data are locally collected and held by nodes. Our work aims to improve the regression estimation efficiency by aggregating the neighbors’ information while also identifying the cluster membership for nodes. To achieve efficient estimation and clustering, we...

Additional file 6 of Small molecule modulation of microbiota: a systems pharmacology perspective

Qiao Liu, Bohyun Lee & Lei Xie
Additional file 6. Table S5. Drugs that are found in both drug screen results using Drugbank database and that using STITCH database.

Additional file 7 of Comparative analysis of the complete chloroplast genomes of six threatened subgenus Gynopodium (Magnolia) species

Huanhuan Xie, Lei Zhang, Cheng Zhang, Hong Chang, Zhenxiang Xi & Xiaoting Xu
Additional file 7: Table S4. Accession numbers of the CPGs used in the phylogenetic analysis.

Additional file 1 of MetaRNN: differentiating rare pathogenic and rare benign missense SNVs and InDels using deep learning

Chang Li, Degui Zhi, Kai Wang & Xiaoming Liu
Additional file 1: Includes 11 tables for training and testing data sets used in the study. The names of the tables are: Table S1. Training variants for MetaRNN; Table S2. Training variants for MetaRNN-indel; Table S3. Summary statistics for test datasets used to evaluate MetaRNN; Table S4. RNTS validation data set for MetaRNN model evaluation; Table S5. RCTS validation data set for MetaRNN model evaluation; Table S6. AF-RNTS validation data set for MetaRNN model evaluation;...

Additional file 1 of MetaRNN: differentiating rare pathogenic and rare benign missense SNVs and InDels using deep learning

Chang Li, Degui Zhi, Kai Wang & Xiaoming Liu
Additional file 1: Includes 11 tables for training and testing data sets used in the study. The names of the tables are: Table S1. Training variants for MetaRNN; Table S2. Training variants for MetaRNN-indel; Table S3. Summary statistics for test datasets used to evaluate MetaRNN; Table S4. RNTS validation data set for MetaRNN model evaluation; Table S5. RCTS validation data set for MetaRNN model evaluation; Table S6. AF-RNTS validation data set for MetaRNN model evaluation;...

Registration Year

  • 2022
    1,073

Resource Types

  • Dataset
    1,073

Affiliations

  • Peking University
    1,073
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    677
  • Zhejiang University
    619
  • Huazhong University of Science and Technology
    580
  • Shanghai Jiao Tong University
    574
  • Capital Medical University
    563
  • Sichuan University
    558
  • Chinese Academy of Sciences
    495
  • Fudan University
    491
  • University of Chinese Academy of Sciences
    444