Additional file 3. MeRIP sequencing identified 496 differentially peaks for MM cells transfected with sh-HNRNPA2B1-8226 and the control sh-NC-8226.

Additional file 11: Table S8. KEGG pathway analysis of Model, S+Rg, S, and Rg groups.

Additional file 2: Table S1. Marker genes for all subclusters in the overall dataset. Table S2. Marker genes for subclusters in the endothelial cells. Table S3. Marker genes for UCell scoring in each EC subtypes. Table S4. The primers and shRNA sequences used in PCR. Table S5. Differentially expressed gene list of Healing EC between MCAO and sham conditions. Table S6. Gene sets enrichment analysis in Healing EC by comparing MCAO and sham condition. Table...

Additional file 6: Table S1. The primer sequences uesd in RT-qPCR.

Additional file 25: Table S3. Integrated Multi-omics Features in Tumor Tissues Compared with NATs of the PDAC. Table S3A Matrix of 7,055 protein groups and their relative intensities in at least 1/6 of the samples (226 tumors and 220 NATs). Table S3B 19,992 mRNA and their ratio of tumors/NATs (54 tumors and 51 NATs). Table S3C A list of protein identified both in protein and mRNA level. Table S3D A list of phosphosites used for...

Additional file 25: Table S3. Integrated Multi-omics Features in Tumor Tissues Compared with NATs of the PDAC. Table S3A Matrix of 7,055 protein groups and their relative intensities in at least 1/6 of the samples (226 tumors and 220 NATs). Table S3B 19,992 mRNA and their ratio of tumors/NATs (54 tumors and 51 NATs). Table S3C A list of protein identified both in protein and mRNA level. Table S3D A list of phosphosites used for...

Additional file 28: Table S6. Proteomic Subtypes of PDAC Patients. Table S6A Proteomic subtypes, transcriptomic subtypes and phosphoproteomic subtypes of PDAC patients. Table S6B A list of differentially expressed proteins among three subtypes. Table S6C Pathway alterations in the proteomic subtypes of the PDAC cohort. Table S6D Matrix of protein expression and kinase activity of kinase activated in S-III. Table S6E Matrix of differential pathway enrichment between patients located in H-PDAC and BT-PDAC. Table S6F...

With the ongoing COVID-19 pandemic and the emergence of various SARS-CoV-2 variants, a comprehensive evaluation of long-term efficacy of antibody response in convalescent individuals is urgently needed. Several longitudinal studies had reported the antibody dynamics after SARS-CoV-2 acute infection, but the follow-up was mostly limited to 1 year or 18 months at the maximum. In this study, we investigated the durability, potency, and susceptibility to immune evasion of SARS-CoV-2-specific antibody in COVID-19 convalescents for 2...

It remains controversial whether primary tumor resection (PTR) improves survival in patients with asymptomatic, unresectable metastatic colorectal cancer (mCRC). Therefore, we conducted a meta-analysis to assess the latest evidence on clinical outcomes. We systematically searched PubMed, Web of Science, Cochrane Library, and Embase databases for eligible studies published between database inception and May 2022. RevMan 5.4 and Stata 16.0 were used for the meta-analysis. A total of nine studies were included, including four randomized controlled...

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Additional file 3:

Additional file 4: Table S4. The GO and KEGG enrichment analysis of cis‑ and trans- target genes for dif-lncRNAs at 3 hpi and 12 hpi.

Additional file 4: Table S4. The GO and KEGG enrichment analysis of cis‑ and trans- target genes for dif-lncRNAs at 3 hpi and 12 hpi.

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The data include volcanic aerosol forcing over different ocean and land regions, and monthly precipitation, sea surface temperature, sea surface height, and 850hPa zonal wind.

Predicting acute oral toxicity LD50 of chemicals in rats is a challenge since many factors affect toxicity data. In this paper, 40 descriptors were successfully used to develop a quantitative structure–activity relationship model for 8448 rat acute oral toxicity logLD50 by applying the random forest (RF) algorithm. To develop the optimal RF model, a training set (5914 chemicals) was used to establish models, a validation set (1267 chemicals) used to tune RF parameters and a...

Plastic take-out food containers may release microplastics (MPs) into food and pose a potential risk to food safety and human health. Here, after being subjected to hot water treatment, MPs released from three types of plastic food containers (polypropylene, PP; polyethylene, PE; expanded polystyrene, EPS) were identified by micro-Raman spectroscopy. The results showed that the size of released MPs ranged from 0.8–38 μm and over 96% MPs were smaller than 10 μm. Various MPs concentrations...

Nucleomodulins are secreted bacterial proteins whose molecular targets are located in host cell nuclei. They are gaining attention as critical virulence factors that either modify the epigenetics of host cells or directly regulate host gene expression. Mycoplasma bovis is a major veterinary pathogen that secretes several potential virulence factors. The aim of this study was to determine whether any of their secreted proteins might function as nucleomodulins. After an initial in silico screening, the nuclear...

Mutations in WNT1 can cause rare inherited disorders such as osteogenesis imperfecta (OI) and early-onset osteoporosis (EOOP). Due to its rarity, the clinical characteristics and pathogenic mechanism of WNT1 mutations remain unclear. We aimed to explore the phenotypic and genotypic spectrum and treatment responses of a large cohort of patients with WNT1-related OI/OP and the molecular mechanisms of WNT1 variants. The phenotypes and genotypes of patients and their responses to bisphosphonates or denosumab were evaluated....

Additional file 2: Table S2. The GSVA results of TCGA-PRAD dataset.

Additional file 2: Table S2. The GSVA results of TCGA-PRAD dataset.

Additional file 6: Table S6. The GSVA results of GSE70769 dataset.

Additional file 6: Table S6. The GSVA results of GSE70769 dataset.