6 Works

Data from: Asthma-like symptoms in homeless children in the Greater Paris area in 2013: prevalence, associated factors and utilization of healthcare services in the ENFAMS survey

Delphine Lefeuvre, Marie-Christine Delmas, Christophe Marguet, Pierre Chauvin & Stéphanie Vandentorren
Asthma remains poorly studied in homeless children. We sought to estimate the prevalence of asthma-like symptoms (ALS) and to identify the factors associated with ALS and healthcare service utilisation. Materials and Methods: A cross-sectional survey of a random sample of sheltered homeless families was conducted by interviewing 801 parents of children (0–12 years) in 17 languages. ALS were defined as wheezing or night cough without fever during the previous year. Poisson regression models with robust...

Data from: Tempo and mode of genome evolution in a 50,000-generation experiment

Olivier Tenaillon, Jeffrey E. Barrick, Noah Ribeck, Daniel E. Deatherage, Jeffrey L. Blanchard, Aurko Dasgupta, Gabriel C. Wu, Sébastien Wielgoss, Stéphane Cruveiller, Claudine Médigue, Dominique Schneider & Richard E. Lenski
Adaptation by natural selection depends on the rates, effects and interactions of many mutations, making it difficult to determine what proportion of mutations in an evolving lineage are beneficial. Here we analysed 264 complete genomes from 12 Escherichia coli populations to characterize their dynamics over 50,000 generations. The populations that retained the ancestral mutation rate support a model in which most fixed mutations are beneficial, the fraction of beneficial mutations declines as fitness rises, and...

Data from: Convergent evolution of sperm gigantism and the developmental origins of sperm size variability in Caenorhabditis nematodes

Anne Vielle, Nicolas Callemeyn-Torre, Clotilde Gimond, Nausicaa Poullet, Jeremy C. Gray, Asher D. Cutter & Christian Braendle
Sperm cells provide essential, if usually diminutive, ingredients to successful sexual reproduction. Despite this conserved function, sperm competition and coevolution with female traits can drive spectacular morphological change in these cells. Here, we characterize four repeated instances of convergent evolution of sperm gigantism in Caenorhabditis nematodes using phylogenetic comparative methods on 26 species. Species at the extreme end of the 50-fold range of sperm-cell volumes across the genus have sperm capable of comprising up to...

Data from: Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin treated mouse gut

Mathilde Lescat, Launay Adrien, Mohamed Ghalayini, Mélanie Magnan, Jérémy Glodt, Coralie Pintard, Sara Dion, Erick Denamur, Olivier Tenaillon & Adrien Launay
Though microbial ecology of the gut is now a major focus of interest, little is known about the molecular determinants of microbial adaptation in the gut. Experimental evolution coupled with whole genome sequencing can provide insights of the adaptive process. In vitro experiments have revealed some conserved patterns: intermediate convergence, epistatic interactions between beneficial mutations and mutations in global regulators. To test the relevance of these patterns and to identify the selective pressures acting in...

Data from: Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains

Filippo Casoni, Samuel A. Malone, Morgane Belle, Federico Luzzati, Francis Collier, Cecile Allet, Erik Hrabovszky, Sowmyalakshmi Rasika, Vincent Prevot, Alain Chedotal & Paolo Giacobini
Fertility in mammals is controlled by hypothalamic neurons that secrete gonadotropin-releasing hormone (GnRH). These neurons differentiate in the olfactory placodes during embryogenesis and migrate from the nose to the hypothalamus before birth. Information regarding this process in humans is sparse. Here, we adapted new tissue-clearing and whole-mount immunohistochemical techniques to entire human embryos/fetuses to meticulously study this system during the first trimester of gestation in the largest series of human fetuses examined to date. Combining...

Data from: Large-scale functional networks identified from resting-state EEG using spatial ICA

Denis P. Schwartz, Stéphane Sockeel, Mélanie Pélégrini-Issac, Habib Benali & Denis Schwartz
Several methods have been applied to EEG or MEG signals to detect functional networks. In recent works using MEG/EEG and fMRI data, temporal ICA analysis has been used to extract spatial maps of resting-state networks with or without an atlas-based parcellation of the cortex. Since the links between the fMRI signal and the electromagnetic signals are not fully established, and to avoid any bias, we examined whether EEG alone was able to derive the spatial...

Registration Year

  • 2016

Resource Types

  • Dataset


  • Inserm
  • University of Massachusetts Amherst
  • The University of Texas at Austin
  • Biomedical Imaging Lab
  • French National Centre for Scientific Research
  • University of Lille
  • Paris Diderot University
  • Grenoble Alpes University
  • Institute of Experimental Medicine
  • University of Toronto