8 Works

Data from: Biogeography of Leptospira in wild animal communities inhabiting the insular ecosystem of the western Indian Ocean islands and neighboring Africa

Muriel Dietrich, Yann Gomard, Erwan Lagadec, Beza Ramasindrazana, Gildas Le Minter, Vanina Guernier, Aude Benlali, Gérard Rocamora, Wanda Markotter, Steve M. Goodman, Koussay Dellagi, Pablo Tortosa & Steven M. Goodman
Understanding the processes driving parasite assemblages is particularly important in the context of zoonotic infectious diseases. Leptospirosis is a widespread zoonotic bacterial infection caused by pathogenic species of the genus Leptospira. Despite a wide range of animal hosts, information is still lacking on the factors shaping Leptospira diversity in wild animal communities, especially in regions, such as tropical insular ecosystems, with high host species richness and complex biogeographical patterns. Using a large dataset (34 mammal...

Data from: Pattern of polyphenol intake and the long-term risk of dementia in older persons

Sophie Lefèvre-Arbogast, David Gaudout, Julien Bensalem, Luc Letenneur, Jean-François Dartigues, Boris P. Hejblum, Catherine Féart, Cécile Delcourt & Cécilia Samieri
Objective: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study. Methods: We included 1,329 non-demented older adults from the 3C Study with assessment of intake of 26 polyphenol subclasses and followed for 12 years for dementia. Using Partial Least Square for Cox models, we identified a pattern of polyphenol intake associated with dementia risk. Results: The...

Data from: Evaluation of exposure to effervescent drugs in a large health check-up population in France: a cross-sectional study

Germain Perrin, Sarah Berdot, Frédérique Thomas, Bruno Pannier, Nicolas Danchin, Pierre Durieux & Brigitte Sabatier
OBJECTIVES: The relationship between high dietary sodium intake and hypertension is well established. Some drugs are associated with high-sodium content, particularly effervescent tablets (ETs). Despite a possible cardiovascular risk associated with the use of such drugs, observational data describing exposure to ETs in ambulatory subjects are lacking. The aim of this study was to estimate the prevalence of exposure to ETs, and to highlight factors associated with this exposure, in a large French health check-up...

Data from: Immune checkpoint inhibitor–related myositis and myocarditis in patients with cancer

Mehdi Touat, Thierry Maisonobe, Samuel Knauss, Omar Ben Hadj Salem, Baptiste Hervier, Karine Auré, Tali-Anne Szwebel, Nora Kramkimel, Claire Lethrosne, Jean-Frédéric Bruch, Pauline Laly, Jacques Cadranel, Nicolas Weiss, Anthony Béhin, Yves Allenbach, Olivier Benveniste, Timothée Lenglet, Dimitri Psimaras, Werner Stenzel & Sarah Léonard-Louis
Objective: To report the clinicopathological features and outcome of myositis in patients treated with immune checkpoint inhibitors (irMyositis). Methods: We retrospectively analyzed patients diagnosed with irMyositis in tertiary centers in Paris, France, and Berlin, Germany, from January 2015, to July 2017. Main outcomes were clinical manifestations and muscle histology, which included MHC-I, C5b-9, CD3, CD4, CD8, CD20, CD68, PD-1, PD-L1 and PD-L2 immunohistochemical stains. Results: Ten patients with metastatic cancer were included; median age was...

Data from: Developmental venous anomaly in diffuse glioma adult patients: a clinically relevant coexistence?

Alexandre Roux, Myriam Edjlali, Sayuri Porelli, Arnault Tauziede, Marc Zanello, Edouard Dezamis, Gilles Zha-Bi, Marc Sanson, Stéphanie Puget, Laurent Capelle, Pascale Varlet, Catherine Oppenheim & Johan Pallud
Objective: To determine the prevalence of developmental venous anomaly in diffuse glioma adult patients. Methods: We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in two centers: Sainte-Anne Hospital (experimental and control sets), and Pitié-Salpêtrière Hospital (external validation set). We included 219 diffuse glioma patients (experimental set), 252 brain metastasis patients (control set), and 200 diffuse glioma patients (validation set). The inclusion criteria were: age ≥18 years at...

Data from: Electrically induced verbal perseveration: a striatal deafferentation model

Emmanuel Mandonnet, Guillaume Herbet, Sylvie Moritz-Gasser, Isabelle Poisson, Francois Rheault & Hugues Duffau
Objective: The present study aimed to elucidate the neural correlates of the deafferentation cognitive model of verbal perseveration (VP) by analyzing the connectomics of the sites where electrical stimulation elicited VP during awake left glioma surgery. Methods: We retrospectively reviewed the anatomical sites that generated VP when electrically stimulated, in a series of 21 patients operated on while awake for a left glioma. Each stimulation point was manually located on the postoperative MRI and then...

Data from: Longitudinal analysis of impulse control disorders in Parkinson’s disease

Jean-Christophe Corvol, Fanny Artaud, Florence Cormier-Dequaire, Olivier Rascol, Franck Durif, Pascal Derckinderen, Ana-Raquel Marques, Frédéric Bourdain, Jean-Philippe Brandel, Fernando Pico, Lucette Lacomblez, Cecilia Bonnet, Christine Brefel-Courbon, Fabienne Ory-Magne, David Grabli, Stephan Klebe, Graziella Mangone, Hana You, Valérie Mesnages, Pei-Chen Lee, Alexis Brice, Marie Vidailhet & Alexis Elbaz
Objective: To investigate the longitudinal dose-effect relationship between dopamine replacement therapy and impulse control disorders (ICDs) in Parkinson’s disease (PD). Methods: We used data from a multicentre longitudinal cohort of consecutive PD patients with ≤5y disease duration at baseline followed annually up to 5y. ICDs were evaluated during face-to-face semi-structured interviews with movement disorder specialists. Generalized estimating equations Poisson models with robust variance were used to study the association between several time-dependent definitions of dopamine...

Data from: Predictors of new remote cerebral microbleeds after intravenous thrombolysis for ischemic stroke

Tim Bastian Braemswig, Kersten Villringer, Guillaume Turc, Hebun Erdur, Jochen B. Fiebach, Heinrich J. Audebert, Matthias Endres, Christian H. Nolte & Jan F. Scheitz
Objective: To assess the frequency, associated factors, and underlying vasculopathy of new remote cerebral microbleeds (CMB), as well as the risk of concomitant hemorrhagic complications related to new CMBs, after intravenous thrombolysis (IVT) in acute stroke patients. Methods: We conducted an observational study using data from our local thrombolysis registry. We included consecutive stroke patients with MRI (3-Tesla)-based IVT and a follow-up MRI the next day between 2008–2017 (n=396). Only CMBs located outside of the...

Registration Year

  • 2018

Resource Types

  • Dataset


  • Inserm
  • Charité
  • University of Pretoria
  • Université de Sherbrooke
  • Field Museum of Natural History
  • Hôpital Cochin
  • University of Toulouse
  • National Taipei University of Nursing and Health Science
  • Humboldt University of Berlin
  • Paris Descartes University