51 Works

Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma

Ke Shi, Xinyue Zhu, Jiali Wu, Yuhong Chen, Jingfa Zhang & Xiaodong Sun
Retinoblastoma is the most common intraocular malignancy during childhood. Currently, there is no effective treatment for metastatic retinoblastoma. We investigated potential biomarkers of retinoblastoma by utilizing three datasets from a public database. Functional enrichment analysis, including gene ontology, Kyoto encyclopedia of genes and genomes, gene set enrichment analysis and variation analysis, suggested that differentially expressed genes in retinoblastoma were enriched in accelerated cell cycle events. Protein-protein interaction analysis constructed a network consisting of six hub...

Identification and verification of vascular cell adhesion protein 1 as an immune-related hub gene associated with the tubulointerstitial injury in diabetic kidney disease

Yan Jia, Hui Xu, Qi Yu, Lishan Tan & Zuying Xiong
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), but the pathogenesis is not completely understood. Tubulointerstitial injury plays critical roles in the development and progression of DKD. The present study aimed to investigate the profile of tubulointerstitial immune cell infiltration and reveal the underlying mechanisms between tubular cell injury and interstitial inflammation in DKD using bioinformatics strategies. First, xCell analysis identified immune cells displaying significant...

Additional file 1 of Agreement and correlation of abdominal skeletal muscle area measured by CT and MR imaging in cirrhotic patients

Zhengyu Xu, Jia Luo, Dawei Yang, Hui Xu, Jidong Jia & Zhenghan Yang
Additional file 1. Table S1. The original data of the baseline clinical characteristics of the patients.

Additional file 1 of Expanding known viral diversity in plants: virome of 161 species alongside an ancient canal

Shixing Yang, Qingqing Mao, Yan Wang, Jingxian He, Jie Yang, Xu Chen, Yuqing Xiao, Yumin He, Min Zhao, Juan Lu, Zijun Yang, Ziyuan Dai, Qi Liu, Yuxin Yao, Xiang Lu, Hong Li, Rui Zhou, Jian Zeng, Wang Li, Chenglin Zhou, Xiaochun Wang, Quan Shen, Hui Xu, Xutao Deng, Eric Delwart … & Wen Zhang
Additional file 1. Table S1: Plant species and library information.

SETD2 detection may reveal response to induction therapy and survival profile in acute myeloid leukemia patients

Hui Liu
SET domain containing protein 2 (SETD2) involves in the progression and development of chemotherapy resistance in acute myeloid leukemia (AML). Hence, this study aimed to investigate the relationship of SETD2 expression with disease risk, features, treatment response, and survival profile in AML. One-hundred and sixty primary AML patients were retrospectively analyzed. Their bone marrow (BM) samples before and after induction therapy were retrieved for SETD2 detection by RT-qPCR. Moreover, SETD2 expression in BM samples of...

Supplimentary Information.docx

Deepak Joshi, Heidi L. Sieverding, Hui Xu, Hoyoung Kwon, Michael Wang, Sharon A Clay, Jane M. Johnson, Resham Thapa, Shaina Westhoff & David E. Clay
Data from : A Global Meta-analysis of Cover Crop Response on Soil Carbon Storage Within a Corn Production System

Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma

Ke Shi, Xinyue Zhu, Jiali Wu, Yuhong Chen, Jingfa Zhang & Xiaodong Sun
Retinoblastoma is the most common intraocular malignancy during childhood. Currently, there is no effective treatment for metastatic retinoblastoma. We investigated potential biomarkers of retinoblastoma by utilizing three datasets from a public database. Functional enrichment analysis, including gene ontology, Kyoto encyclopedia of genes and genomes, gene set enrichment analysis and variation analysis, suggested that differentially expressed genes in retinoblastoma were enriched in accelerated cell cycle events. Protein-protein interaction analysis constructed a network consisting of six hub...

miR-199a-3p plays an anti-tumorigenic role in lung adenocarcinoma by suppressing anterior gradient 2

Hui Liu, Yanfeng Wang, Yi Wang, Daoyuan Wu & He Zhang
Previous studies have explored the association between protein-coding genes and microRNAs (miRNAs) in lung adenocarcinoma (LUAD). However, the influence of the miR-199a-3p/anterior gradient 2 (AGR2) axis in LUAD has not yet been fully explored. Therefore, this study aimed to examine the underlying roles of AGR2 and miR-199a-3p in the development of LUAD. The expression levels of miR-199a-3p and AGR2 in LUAD tissues and cells were detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A luciferase...

Hypoxia triggers the outbreak of infectious spleen and kidney necrosis virus disease through viral hypoxia response elements

Jian He, Yang Yu, Zhi-Min Li, Zhi-Xuan Liu, Shao-Ping Weng, Chang-Jun Guo & Jian-Guo He
Hypoxia frequently occurs in aquatic environments, especially in aquaculture areas. However, research on the relationship between hypoxic aquatic environments with viral diseases outbreak is limited, and its underlying mechanisms remain elusive. Herein, we demonstrated that hypoxia directly triggers the outbreak of infectious spleen and kidney necrosis virus (ISKNV) disease. Hypoxia or activated hypoxia-inducible factor (HIF) pathway could remarkably increase the levels of viral genomic DNA, titers, and gene expression, indicating that ISKNV can response to...

Hypoxia triggers the outbreak of infectious spleen and kidney necrosis virus disease through viral hypoxia response elements

Jian He, Yang Yu, Zhi-Min Li, Zhi-Xuan Liu, Shao-Ping Weng, Chang-Jun Guo & Jian-Guo He
Hypoxia frequently occurs in aquatic environments, especially in aquaculture areas. However, research on the relationship between hypoxic aquatic environments with viral diseases outbreak is limited, and its underlying mechanisms remain elusive. Herein, we demonstrated that hypoxia directly triggers the outbreak of infectious spleen and kidney necrosis virus (ISKNV) disease. Hypoxia or activated hypoxia-inducible factor (HIF) pathway could remarkably increase the levels of viral genomic DNA, titers, and gene expression, indicating that ISKNV can response to...

Whole-Rock Geochemistry, Zircon U-Pb geochronology and Lu-Hf isotopic constraints on metasedimentary rocks (Paragneisses) in Stornes Peninsula, Larsemann Hills,East Antarctica

Shi Zong, Liudong Ren, Meiqian Wu, Hui Xu & Shifei Zhu
Understanding the geological history of the Larsemann Hills and other exposures along the southeastern coast of Prydz Bay is essential for reconstructing the formation and evolution of the East Gondwana continent. This research involves analyses of the major elements, trace elements, REE, U-Pb and Lu-Hf isotopes of zircons from the metasedimentary rocks found in the Larsemann Hills. The results suggest that the provenance of the metasedimentary rocks within the Larsemann Hills is mainly Mesoproterozoic to...

Southwest China, the last refuge of continental primates in East Asia

He Zhang, Jiqi Lu, Shiyi Tang, Zhipang Huang, Liangwei Cui, Daoying Lan, Rong Hou, Wen Xiao, Haitao Wang, Songtao Guo Guo, Gang He, Kang Huang, Pei Zhang, Hao Pan, Charles Oxnard, Ruliang Pan & Baoguo Li
Knowledge of primate evolutionary history from the Late Miocene to the present in East Asia is necessary to develop a tangible conservation strategy for their today and future. This background is especially evident from the distributions of fossil-bearing sites in the Pleistocene and historical records over the past 800 years. They illustrate catarrhines’ early dispersal and radiation routes, paths, and later shrinking trajectories, based on which their future distribution areas can be predicted, providing robust...

Additional file 9 of Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin & David F. Stroncek
Additional file 9: Table S4. Differential integration sites at gene locus based on clinical outcomes.

Additional file 1 of A novel surgical technique in transforaminal lumbar interbody fusion by the bone graft delivery device: evaluation of therapeutic effect in patients with minimally invasive spine surgery

Kai-shun Yang, Chih-Wei Chen, Ru-Bin Yau, Huang-Chien Liang, Ching-Chung Ko, Jinn-Rung Kuo, Chung-Ching Chio & Sher-Wei Lim
Additional file 1. Patient data in this study.

Protective effects of psoralen polymer lipid nanoparticles on doxorubicin - induced myocardial toxicity

Fansu Meng, Yong Ouyang, Qianqian Ma, Manling Du, Hui Liu, Yong Zhuang, Mujuan Pang, Tiange Cai & Yu Cai
Abstract Doxorubicin (DOX) induced myocardial toxicity may limit its therapeutic use in clinic. Psoralen (PSO), a major active tricyclic furocoumarin extracted from Psoralea corylifolia, is widely used as an antineoplastic agent in treatment of leukemia and other cancers. This study is aim to find the protective effect of psoralen polymer lipid nanoparticles (PSO-PLN) on doxorubicin-induced myocardial toxicity in mice. The model of myocardial toxicity induced by DOX was established. The experiment was divided into 6...

Supplimentary Information.docx

Deepak Joshi, Heidi L. Sieverding, Hui Xu, Hoyoung Kwon, Michael Wang, Sharon A Clay, Jane M. Johnson, Resham Thapa, Shaina Westhoff & David E. Clay
Data from : A Global Meta-analysis of Cover Crop Response on Soil Carbon Storage Within a Corn Production System

Allelic and haplotypic polymorphisms and paternal genetic analysis of Chinese Shaanxi Han population utilizing a multiplex Y-STR set

Hui Xu, Ming Zhao, Shuyan Mei, Yunying Zhang, Meiming Cai, Fanzhang Lei & Bofeng Zhu
The analysis of Y chromosomal genetic markers is of great significance in human genetic fields related to male individuals. The Han nationality is the most populous ethnic group. It is critical to investigate the Y-chromosome short tandem repeat (Y-STR) genetic informativeness of Han nationalities in different Chinese regions in order to gain a comprehensive understanding of their paternal genetic relationships and origin. To assess the allelic and haplotypic polymorphisms of the novel AGCU Y SUPP...

Additional file 11 of Evolution and functional analysis of the GRAS family genes in six Rosaceae species

Yibo Bai, Hui Liu, Kaikai Zhu & Zong-Ming Cheng
Additional file 11: Table S1. Total of 333 GRAS genes were identified in six Rosaceae species. Table S2. Ks values of six Rosaceae species. Table S3. Duplication events of six Rosaceae species. Table S4. ka/Ks values of six Rosaceae species. Table S5. Primers used to detect drought stress and salt stress gene expression.

The fungal pathogen Fusarium solani poses an increasing threat to tomato production in Northern China

Chunyan Chen, Mingxuan Ma, Genzhong Liu, Fangfang Ma & Zhilong Bao
Greenhouse cultivation conditions, such as low light intensity, high humidity and limited crop rotation, result in an increased severity of foot rot disease. Here, we isolated a fungal pathogen from tomato plants infected with foot rot disease to investigate its pathogenicity and establish an inoculation system to distinguish tomato susceptible and resistant varieties. Microscopic analyses of the fungal spores suggested that the pathogen belonged to the genus Fusarium, while polymerase chain reaction amplification of internal...

Data from: A new moth-preying alpine pitviper species from Qinghai-Tibetan plateau (Viperidae, Crotalinae)

Jingsong Shi, Gang Wang, Xi'er Chen, Li Ding, Song Huang, Mian Hou, Jun Liu, Pipeng Li, Xi’er Chen & Yihao Fang
The Sanjiangyuan region of Qinghai-Tibetan Plateau is recognized as a biodiversity hotspot of alpine mammals but a barren area in terms of amphibians and reptiles. Here, we describe a new pit viper species, Gloydius rubromaculatus sp. n. Shi, Li and Liu, 2017 that was discovered in this region, with a brief taxonomic revision of the genus Gloydius. The new species can be distinguished from the other congeneric species by the following characteristics: cardinal crossbands on...

Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma

Ke Shi, Xinyue Zhu, Jiali Wu, Yuhong Chen, Jingfa Zhang & Xiaodong Sun
Retinoblastoma is the most common intraocular malignancy during childhood. Currently, there is no effective treatment for metastatic retinoblastoma. We investigated potential biomarkers of retinoblastoma by utilizing three datasets from a public database. Functional enrichment analysis, including gene ontology, Kyoto encyclopedia of genes and genomes, gene set enrichment analysis and variation analysis, suggested that differentially expressed genes in retinoblastoma were enriched in accelerated cell cycle events. Protein-protein interaction analysis constructed a network consisting of six hub...

miR-199a-3p plays an anti-tumorigenic role in lung adenocarcinoma by suppressing anterior gradient 2

Hui Liu, Yanfeng Wang, Yi Wang, Daoyuan Wu & He Zhang
Previous studies have explored the association between protein-coding genes and microRNAs (miRNAs) in lung adenocarcinoma (LUAD). However, the influence of the miR-199a-3p/anterior gradient 2 (AGR2) axis in LUAD has not yet been fully explored. Therefore, this study aimed to examine the underlying roles of AGR2 and miR-199a-3p in the development of LUAD. The expression levels of miR-199a-3p and AGR2 in LUAD tissues and cells were detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A luciferase...

Identification and verification of vascular cell adhesion protein 1 as an immune-related hub gene associated with the tubulointerstitial injury in diabetic kidney disease

Yan Jia, Hui Xu, Qi Yu, Lishan Tan & Zuying Xiong
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), but the pathogenesis is not completely understood. Tubulointerstitial injury plays critical roles in the development and progression of DKD. The present study aimed to investigate the profile of tubulointerstitial immune cell infiltration and reveal the underlying mechanisms between tubular cell injury and interstitial inflammation in DKD using bioinformatics strategies. First, xCell analysis identified immune cells displaying significant...

Decomposing niche components reveals simultaneous effects of opposite deterministic processes structuring alpine small mammal assembly

Wenyu Song, Kenneth Otieno Onditi, Xueyou Li, Zhongzheng Chen, Shuiwang He, Quan Li & Xuelong Jiang
Our knowledge of community assembly dynamics under multiple stressors is limited because of opposite niche-based processes, i.e., limiting similarity and habitat filtering could simultaneously occur, masking the overall patterns. Alpine biomes provide the ideal systems to explore the influences of co-occurrence processes as these communities usually face multiple stresses such as resources limitation and habitat constraints. However, the assembly processes of mammals in alpine areas have hardly been exclusively studied. Here, we aimed to address...

Protective effects of psoralen polymer lipid nanoparticles on doxorubicin - induced myocardial toxicity

Fansu Meng, Yong Ouyang, Qianqian Ma, Manling Du, Hui Liu, Yong Zhuang, Mujuan Pang, Tiange Cai & Yu Cai
Abstract Doxorubicin (DOX) induced myocardial toxicity may limit its therapeutic use in clinic. Psoralen (PSO), a major active tricyclic furocoumarin extracted from Psoralea corylifolia, is widely used as an antineoplastic agent in treatment of leukemia and other cancers. This study is aim to find the protective effect of psoralen polymer lipid nanoparticles (PSO-PLN) on doxorubicin-induced myocardial toxicity in mice. The model of myocardial toxicity induced by DOX was established. The experiment was divided into 6...

Registration Year

  • 2023
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Resource Types

  • Dataset
    51

Affiliations

  • Dali University
    51
  • Huazhong Agricultural University
    26
  • Zhejiang University
    25
  • Sichuan University
    25
  • Nanfang Hospital
    25
  • Chinese Academy of Sciences
    25
  • Huazhong University of Science and Technology
    23
  • Anhui Medical University
    21
  • Capital Medical University
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  • Peking University
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