489 Works

WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP

Guang Lu, Hayden Weng Siong Tan, Tomas Schmauck-Medina, Liming Wang, Jiaqing Chen, Yik-Lam Cho, Kelie Chen, Jing-Zi Zhang, Weifeng He, Yihua Wu, Dajing Xia, Jing Zhou, Evandro F. Fang, Lei Fang, Wei Liu & Han-Ming Shen
The mammalian Atg18 ortholog WIPI2 is a key regulator of LC3 lipidation to promote autophagosome biogenesis during nonselective macroautophagy, while its functions in selective autophagy such as mitophagy remain largely unexplored. In this study, we explored the role of WIPI2 in PINK1-PRKN/parkin-mediated mitophagy. First, we found that WIPI2 is recruited to damaged mitochondria upon mitophagy induction. Second, loss of WIPI2 impedes mitochondrial damaging agents-induced mitophagy. Third, at molecular level, WIPI2 binds to and promotes AAA-ATPase...

ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation

Jilong Zhou, Hainan He, Jing-Jing Zhang, Xin Liu, Wang Yao, Chengyu Li, Tian Xu, Shu-Yuan Yin, Dan-Ya Wu, Cheng-Li Dou, Qiao Li, Jiani Xiang, Wen-Jing Xiong, Li-Yan Wang, Jun-ming Tang, Zhouyiyuan Xue, Xia Zhang & Yi-Liang Miao
Macroautophagy/autophagy is a conserved cellular mechanism to degrade unneeded cytoplasmic proteins and organelles to recycle their components, and it is critical for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Whereas autophagy is essential for early development of embryos, no information exists regarding its functions during the transition from naive-to-primed pluripotency. Here, by using an in vitro transition model of ESCs to epiblast-like cells (EpiLCs), we find that dynamic changes in ATG7-dependent autophagy are...

Prevalence of major morbidities and outcome of all hospitalized neonates. A retrospective cohort study of Huai’an neonatal survivals

Yaling Xu, Xiaoqin Zhu, Hui Wang, Zhaojun Pan, Xiaoqiong Li, Xiaojing Guo, Hongni Yue & Bo Sun
Reliable data for causal implication of neonatal survival in China are lacking. We assumed that by analyzing surviving data of in-hospital neonatal care based on all livebirths in Huai’an, prevalence of neonatal morbidity, mortality and causal relations may be derived comprehensively. Data of all regionally hospitalized neonates were retrospectively linked with corresponding whole livebirths (59,056) in 2015 as a cohort. Diagnoses of diseases and causes of deaths were redefined and categorized. Disease patterns, prevalence of...

Sevoflurane reduces lipopolysaccharide-induced apoptosis and pulmonary fibrosis in the RAW264.7 cells and mice models to ameliorate acute lung injury by eliminating oxidative damages

Fushuang Zheng, Xiuying Wu, Jin Zhang, Zhiling Fu & Yan Zhang
Sevoflurane is identified as an effective candidate drug for acute lung injury (ALI) treatment, but its curing effects and detailed mechanisms have not been fully disclosed. The present study was designed to resolve this academic issue. The ALI mice models were established, and Hematoxylin-eosin staining assay was performed to examine tissue morphologies. Cell viability was determined by CCK-8 assay, and Annexin V-FITC/PI double staining assay was used to examine cell apoptosis. The expression levels of...

Additional file 4 of Exogenous ABA and IAA modulate physiological and hormonal adaptation strategies in Cleistocalyx operculatus and Syzygium jambos under long-term waterlogging conditions

El-Hadji Malick Cisse, Juan Zhang, Da-Dong Li, Ling-Feng Miao, Li-Yan Yin & Fan Yang
Additional file 4.

Comparative transcriptome and proteome analyses of the longissimus dorsi muscle for explaining the difference between donkey meat and other meats

Yan Sun, Yonghui Wang, Yuhua Li, Haijing Li, Changfa Wang & Qin Zhang
Domestic donkeys (Equus asinus) have been maintained mainly for service purposes in the past. Nowadays, there is an increasing interest in donkey milk and meat production in several countries, including China. Donkey meat is highly consumed because of its nutritional value and unique flavor. However, genomic studies on donkey meat are limited. Therefore, in this study, we aimed to examine the molecular difference of longissimus dorsi muscles of donkey, cow, and goat. RNA sequencing and...

Additional file 1 of Analysis of risk factors related to extremely and very preterm birth: a retrospective study

Xiaohong Ji, Chengqian Wu, Min Chen, Lili Wu, Ting Li, Zhijing Miao, Yan Lv & Hongjuan Ding
Supplementary Material 1

Genome and annotation of triploid cultivated banana

Xiuxiu Li, Sheng Yu, Zhihao Cheng, Yingzi Yun, Xuequn Chen, Xing Liu, Hua Li, Wenjun Zhu, Shiyao Xu, Yanbing Xu, Chen Zhang, Xianjun Wang, Xingtan Zhang, Zhenguo Lin, Jean-Marc Aury, Yves Van de Peer, Zonghua Wang, Xiaofan Zhou, Peitao Lü & Liangsheng Zhang
Genome assemblies and annotations of Cavendish and Gros Michel bananas

Additional file 12 of Genomic Architecture of Yield Performance of an Elite Rice Hybrid Revealed by its Derived Recombinant Inbred Line and Their Backcross Hybrid Populations

Fan Zhang, Conghe Zhang, Xiuqin Zhao, Shuangbing Zhu, Kai Chen, Guixiang Zhou, Zhichao Wu, Min Li, Tianqing Zheng, Wensheng Wang, Zhi Yan, Qinyong Fei, Zhikang Li, Jinjie Chen & Jianlong Xu
Additional file 12: Table S7. The function of 45 cloned yield related genes identified as the candidate genes for determining the performance of hybrid rice variety QYSM.

Additional file 1 of Effect and mechanisms of kaempferol against endometriosis based on network pharmacology and in vitro experiments

Junde Zhao, Juntao Wang, Jinxing Liu, Shuling Li, Pengfei Liu & Xiaodan Zhang
Additional file 1.

Additional file 1 of Construction of a ferroptosis-related five-lncRNA signature for predicting prognosis and immune response in thyroid carcinoma

Yuan Qin, Dai Zhang, Huan Zhang, Lan Hou, Zhe Wang, Liu Yang, Mingkun Zhang, Ge Zhao, Qing Yao, Rui Ling & Juliang Zhang
Additional file 1: Table S1. Ferroptosis-related genes.

Additional file 3 of Efficacy and safety of Tripterygium wilfordii polyglycosides for diabetic kidney disease: an overview of systematic reviews and meta-analyses

Ying Wang, Mei Han, Yao-Tan Li, Zhen Wang & Jian-Ping Liu
Additional file 3: Supplemental Table 1. Overview of 24-hour Urinary Protein in the Included SRs and MAs. Supplemental Table 2. Overview of the Included SRs and MAs of Renal Function. Supplemental Table 3. Overview of the Included SRs and MAs about the Outcome of Serum Albumin. Supplemental Table 4. Overview of the Included SRs and MAs of AL. Supplemental Table 5. Overview of the included SRs and MAs about the outcomes of WBC. Supplemental Table...

Outdoor air pollution and the risk of asthma exacerbations in single lag0 and lag1 exposure patterns: a systematic review and meta-analysis

Junjun Huang, Xiaoyu Yang, Fangfang Fan, Yan Hu, Xi Wang, Sainan Zhu, Guanhua Ren & Guangfa Wang
Objective: To synthesize evidence regarding the relationship between outdoor air pollution and risk of asthma exacerbations in single lag0 and lag1 exposure patterns. Methods: We performed a systematic literature search using PubMed, Embase, Cochrane Library, Web of Science, ClinicalTrials, China National Knowledge Internet, Chinese BioMedical, and Wanfang databases. Articles published until August 1, 2020 and the reference lists of the relevant articles were reviewed. Two authors independently evaluated the eligible articles and performed structured extraction...

Additional file 8 of Genome-centric insight into metabolically active microbial population in shallow-sea hydrothermal vents

Xiaofeng Chen, Kai Tang, Mu Zhang, Shujing Liu, Mingming Chen, Peiwen Zhan, Wei Fan, Chen-Tung Arthur Chen & Yao Zhang
Additional file 8: Table S7. Genomic and proteomic information of 20 MAGs recovered in this study.

Additional file 1 of Transcriptome profiling of lung immune responses potentially related to acute respiratory distress syndrome in forest musk deer

Jie Tang, Lijuan Suo, Feiran Li, Kun Bian, Chao Yang & Yan Wang
Additional file 1.

Additional file 3 of Genome-centric insight into metabolically active microbial population in shallow-sea hydrothermal vents

Xiaofeng Chen, Kai Tang, Mu Zhang, Shujing Liu, Mingming Chen, Peiwen Zhan, Wei Fan, Chen-Tung Arthur Chen & Yao Zhang
Additional file 3: Table S2. Summary of the metagenome sequencing statistics.

Additional file 6 of Genome-centric insight into metabolically active microbial population in shallow-sea hydrothermal vents

Xiaofeng Chen, Kai Tang, Mu Zhang, Shujing Liu, Mingming Chen, Peiwen Zhan, Wei Fan, Chen-Tung Arthur Chen & Yao Zhang
Additional file 6: Table S5. The average nucleotide identity (ANI) and amino acid identity (AAI) between MAGs and their closes relatives.

Additional file 6 of Genome-centric insight into metabolically active microbial population in shallow-sea hydrothermal vents

Xiaofeng Chen, Kai Tang, Mu Zhang, Shujing Liu, Mingming Chen, Peiwen Zhan, Wei Fan, Chen-Tung Arthur Chen & Yao Zhang
Additional file 6: Table S5. The average nucleotide identity (ANI) and amino acid identity (AAI) between MAGs and their closes relatives.

Additional file 1 of Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma

Tongyan Liu, Chencheng Han, Panqi Fang, Zhifei Ma, Xiaoxiao Wang, Hao Chen, Siwei Wang, Fanchen Meng, Cheng Wang, Erbao Zhang, Guozhang Dong, Hongyu Zhu, Wenda Yin, Jie Wang, Xianglin Zuo, Mantang Qiu, Jinke Wang, Xu Qian, Hongbing Shen, Lin Xu, Zhibin Hu & Rong Yin
Additional file 1. Supplementary Tables.

Additional file 4 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu & Xiaojun Zha
Additional file 4: Supplementary Table S8. List of the downregulated differentially expressed genes from RNA sequencing results in Tsc2-/- MEFs and Tsc2+/+ MEFs. All genes were identified with FDR-adjusted p-value<0.05 and absolute value of log2(FC)>1.

Additional file 3 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu & Xiaojun Zha
Additional file 3: Supplementary Table S7. List of the predict target genes of miR-130b-3p from prediction softwares TargetScan, RNA22, PicTar, miRDB and miRWalk.

Additional file 6 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 6: Table S3. Differentially expressed protein-coding genes in atm mutated flies.

Additional file 9 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 9: Table S6. Differentially expressed miRNAs in atm mutated flies.

Additional file 12 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 12: Table S9. Differentially expressed lncRNAs in atm mutated flies.

ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis

Jinjin Zhang, Haixia Wang, Hongbin Chen, Hongbo Li, Pan Xu, Bo Liu, Qian Zhang, Changjun Lv & Xiaodong Song
Idiopathic pulmonary fibrosis (IPF) is characterized by lung scarring and has no effective treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and migration are major clinical manifestations of this disease; hence, blocking these processes is a practical treatment strategy. Here, highly upregulated LINC00941/lncIAPF was found to accelerate pulmonary fibrosis by promoting fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and migration. Assay for transposase-accessible chromatin using sequencing and chromatin immunoprecipitation experiments elucidated that histone 3 lysine 27 acetylation (H3K27ac) activated...

Registration Year

  • 2022
    489

Resource Types

  • Dataset
    489

Affiliations

  • Peking University First Hospital
    489
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    358
  • Zhejiang University
    314
  • Shanghai Jiao Tong University
    292
  • Fudan University
    285
  • Sichuan University
    267
  • Peking University
    262
  • Capital Medical University
    260
  • University of Chinese Academy of Sciences
    237
  • Huazhong University of Science and Technology
    222