456 Works

Metabolomics research on the effect of dexamethasone‐induced chronic stress in serum of rabbits

Hongli Liu, Bin Zhang, Lei Liu & Fuchang Li
Stress is a common factor that reduces production performance. However, the physiology of stress is not fully understood. In this study, 40-day-old rabbits were injected 1.0 mg/kg BW Dexamethasone to induce stress. A metabolomic study on serum of stress-induced rabbits was performed to research the metabolism mechanism of stress by using ultra-performance liquid chromatography coupled to mass spectrometry (UPLC–MS). Clear separations between stress rabbits and control rabbits were observed by principal component analysis (PCA) based...

Metabolomics research on the effect of dexamethasone‐induced chronic stress in serum of rabbits

Hongli Liu, Bin Zhang, Lei Liu & Fuchang Li
Stress is a common factor that reduces production performance. However, the physiology of stress is not fully understood. In this study, 40-day-old rabbits were injected 1.0 mg/kg BW Dexamethasone to induce stress. A metabolomic study on serum of stress-induced rabbits was performed to research the metabolism mechanism of stress by using ultra-performance liquid chromatography coupled to mass spectrometry (UPLC–MS). Clear separations between stress rabbits and control rabbits were observed by principal component analysis (PCA) based...

Nutritional components and protein quality analysis of genetically modified phytase maize

Yichun Hu, Liqin Linghu, Min Li, Deqian Mao, Yu Zhang, Xiaoguang Yang & Lichen Yang
The nutritional components and protein quality of genetically modified maize expressing phytase gene (GM) were analyzed and evaluated in this study. The nutritional components were analyzed by Chinese national standard methods. The ileostomy Bama miniature pigs were utilized to analyze the true digestibility of protein and amino acids. The digestible indispensable amino acid score (DIAAS) was adopted to evaluate the protein quality of GM, its parental maize (PM) and commercial available maize Zhengdan 958 (ZD)....

A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants

Joy-Yan Lam, Yau-Yee Ng, Chun-Kit Yuen, Wan-Man Wong, Kwok-Yung Yuen & Kin-Hang Kok
SARS-CoV-2 has caused the COVID-19 pandemic since early 2020. As of January 2022, the worldwide spreading of SARS-CoV-2 leads to approximately 0.35 billion of human infections and five millions of deaths. Current vaccination is one of the effective ways to control SARS-CoV-2 transmission and reduce the disease severity. However, the antibody level against the immunogen significantly drops several months after the standard two-dose vaccination, and hence a third or fourth dose booster (the same immunogen)...

Two QTL for kernel number per spike identified from durum wheat

Jingtian Yang, Zhengqiao Liao, Baoguo Du, Kuan Zhang & Lei Liu
As one of the three yield components, kernel number per spike (KNPS) plays a key role in determining wheat yield. In this study, in combination with the previously constructed genetic map for a tetraploid wheat recombinant inbred line (RIL) population developed from the cross between a durum wheat and a wild emmer wheat and phenotype data from four environments, two major and stably expressed quantitative trait loci (QTL) for KNPS were identified. The phenotypic variation...

A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants

Joy-Yan Lam, Yau-Yee Ng, Chun-Kit Yuen, Wan-Man Wong, Kwok-Yung Yuen & Kin-Hang Kok
SARS-CoV-2 has caused the COVID-19 pandemic since early 2020. As of January 2022, the worldwide spreading of SARS-CoV-2 leads to approximately 0.35 billion of human infections and five millions of deaths. Current vaccination is one of the effective ways to control SARS-CoV-2 transmission and reduce the disease severity. However, the antibody level against the immunogen significantly drops several months after the standard two-dose vaccination, and hence a third or fourth dose booster (the same immunogen)...

No consistent effect of daytime versus night-time measurement of thermal tolerance in nocturnal and diurnal lizards

Pauline C Dufour, Toby PN Tsang, Susana Clusella-Trullas & Timothy C Bonebrake
While essential in understanding impacts of climate change for organisms, diel variation remains an understudied component of temporal variation in thermal tolerance limits (i.e. the critical thermal minimum (CTmin) and maximum (CTmax)). For example, a higher Ctmax might be expected for an individual if the measurement is taken during the day (when heat stress is most likely to occur) instead of at night. We measured thermal tolerance (Ctmin and Ctmax) during both the daytime and...

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

Stefanie Allert, Daniela Schulz, Philipp Kämmer, Peter Großmann, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Sascha Brunke & Bernhard Hube
Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, C. auris recently emerged as a new species causing invasive infections with high rates of clinical treatment failures. To mimic initial phases of systemic Candida infections with dissemination via the bloodstream and to elucidate the pathogenic potential of C. auris, we used an ex vivo whole blood...

Data from: Decipher soil organic carbon dynamics and driving forces across China using machine learning

Huiwen Li, Yiping Wu, Shuguang Liu, Jingfeng Xiao, Wenzhi Zhao, Ji Chen, Georgii Alexandrov & Yue Cao
The dynamics of soil organic carbon (SOC) play a critical role in modulating global warming. However, the long-term spatiotemporal changes of SOC at large scale and the impacts of driving forces remain unclear. In this study, we investigated the dynamics of SOC in different soil layers across China through the 1980s to 2010s using a machine learning approach and quantified the impacts of the key factors based on factorial simulation experiments. Our results showed that...

FROM-GLC Plus: toward near real-time and multi-resolution land cover mapping

Le Yu, Zhenrong Du, Runmin Dong, Juepeng Zheng, Ying Tu, Xin Chen, Pengyu Hao, Bo Zhong, Dailiang Peng, Jiyao Zhao, Xiyu Li, Jianyu Yang, Haohuan Fu, Guangwen Yang & Peng Gong
Global land cover has undergone extensive and rapid changes as a result of human activities and climate change. These changes have had a significant impact on biodiversity, the surface energy balance, and sustainable development. Global land cover data underpins research on the development of earth system models, resource management, and evaluation of the ecological environment. However, there are limitations in the classification detail, spatial resolution, and rapid change monitoring capability of global land cover change...

The global distribution of known and undiscovered ant biodiversity

Jamie Kass, Benoit Guénard, Kenneth Dudley, Clinton Jenkins, Fumika Azuma, Brian Fisher, Catherine Parr, Heloise Gibb, John Longino, Philip Ward, Anne Chao, David Lubertazzi, Michael Weiser, Walter Jetz, Robert Guralnick, Rumsaïs Blatrix, James Des Lauriers, David Donoso, Christos Georgiadis, Kiko Gomez, Peter Hawkes, Robert Johnson, John Lattke, Joe MacGown, William Mackay … & Evan Economo
Invertebrates constitute the majority of animal species and are critical for ecosystem functioning and services. Nonetheless, global invertebrate biodiversity patterns and their congruences with vertebrates remain largely unknown. We resolve the first high-resolution (~20-km) global diversity map for a major invertebrate clade, ants, using biodiversity informatics, range modeling, and machine learning to synthesize existing knowledge and predict the distribution of undiscovered diversity. We find that ants and different vertebrate groups have distinct features in their...

Supporting data for \"Controlling avian influenza with public health measures\"

Damien Alain Michel Philippon
This dataset contains the data collected and generated during the PhD. The avian human infections folder contains a dataset from a collection of avian influenza human infections from the published literature and publicly available reports from the WHO, between 1996 to 2021. Information on date of report, age, gender, outcome, exposure, and source (as a DOI or URL to the document providing this information) is available.
The avian interventions folder contains a dataset from...

Figure data for \"High Parametric Efficiency in Laser Cavity-Soliton Microcombs\"

Antonio Cutrona, Maxwell Rowley, Debayan Das, Luana Olivieri, Luke Peters, Sai Ting Chu, Brent E. Little, Roberto Morandotti, David Moss, Juan Sebastian Totero Gongora, Marco Peccianti & Alessia Pasquazi
Figure data for: High Parametric Efficiency in Laser Cavity-Soliton Microcombs Antonio Cutrona1,2, Maxwell Rowley2, Debayan Das1,2 , Luana Olivieri 1,2, Luke Peters 1,2, Sai T. Chu3, Brent E. Little4, Roberto Morandotti5, David J. Moss6, Juan Sebastian Totero Gongora1,2, Marco Peccianti1,2, and Alessia Pasquazi1,2,* 1 Emergent Photonics Research Centre, Dept. of Physics, Loughborough University, Loughborough, LE11 3TU, England, UK 2Emergent Photonics Lab (Epic), Department of Physics and Astronomy, University of Sussex, Brighton, BN1 9QH, UK 3...

Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer

Dan Li, YanWei Shen, Hui Ren, Li Wang, Jin Yang & Yuan Wang
Long non-coding ribonucleic acid 01555 (linc01555) is a brand-new long non-coding RNA (lncRNA) that acts a carcinogenic function in various cancers. However, its role in small cell lung cancer (SCLC) is uncertain. This research was to figure out the role of linc01555 in cisplatin (DDP) resistance of SCLC cells and its possible latent mechanism. After establishment of the resistant sub-strain H446/DDP or DMS-53/DDP, detection of linc01555, microRNA (miR)-122-5p and CLICl was done in the H446/DDP...

Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer

Dan Li, YanWei Shen, Hui Ren, Li Wang, Jin Yang & Yuan Wang
Long non-coding ribonucleic acid 01555 (linc01555) is a brand-new long non-coding RNA (lncRNA) that acts a carcinogenic function in various cancers. However, its role in small cell lung cancer (SCLC) is uncertain. This research was to figure out the role of linc01555 in cisplatin (DDP) resistance of SCLC cells and its possible latent mechanism. After establishment of the resistant sub-strain H446/DDP or DMS-53/DDP, detection of linc01555, microRNA (miR)-122-5p and CLICl was done in the H446/DDP...

Supporting data for \"Large-eddy Simulation of Flow and Pollutant Dispersion behind a Heavy-duty Vehicle\"

Jingwei Xie
The file contains the supporting data for the thesis "Large-eddy Simulation of Flow and Pollutant Dispersion behind a Heavy-duty Vehicle". In the thesis, flow behaviors were examined first to improve the understanding of vehicular wake dynamics with the large-eddy simulation (LES) method. Our LES results were validated by comparing them with wind-tunnel experimental results from a previous study. The comparison result is contained in the "Validation" folder. The analysis of flow and pollutant dispersion is...

Supporting data for \"Unrevealing Parental Mosaicism: The hidden answer to the recurrence of apparent de novo variants\"

Mianne Lee
In this study, I investigated the diagnostic yield of parental mosaicism in a cohort of 21 families with apparent de novo variants (DNVs) associated with neurodevelopmental disorders, and determined the usefulness of the detection of parental mosaicism to the management and genetic counselling of patients. Buccal and sperm samples were collected from the parents to detect potential parental mosaicism by digital PCR (dPCR)/droplet digital PCR (ddPCR), with blocker displacement amplification (BDA) whenever possible.
This...

Additional file 14 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 14. Functional enrichment of genes differentially expressed in the medial preoptic area (MPOA), the nucleus accumbens (NAc), or the lateral septum (LS). For each pairwise comparison, the functional enrichments in gene ontologies of the biological processes (BP), cellular components (CC), and molecular functions (MF) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) were tested for the differentially expressed genes up- or down-regulated (UP, and DOWN, respectively)....

Additional file 21 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 21. Number of immediate early genes (IEG) in the genes differentially expressed in the medial preoptic area (MPOA), nucleus accumbens (NAc), and lateral septum (LS).

Additional file 23 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 23. Functional enrichment for modules and groups of modules derived from the weighted gene co-expression analysis (WGCNA). For each pairwise group of modules, the functional enrichments in gene ontologies (GO) of the biological processes (BP), cellular components (CC), and molecular functions (MF) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG).

Additional file 23 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 23. Functional enrichment for modules and groups of modules derived from the weighted gene co-expression analysis (WGCNA). For each pairwise group of modules, the functional enrichments in gene ontologies (GO) of the biological processes (BP), cellular components (CC), and molecular functions (MF) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG).

Additional file 1 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 1. Table S1: Patient demography.

Supporting data for the \"Development of tailored NGS data analysis pipeline for the diagnosis of Neuromuscular disorders\"

Yao Lei
This dataset is an excel file that summarises information of patients that found potential causal variant(s) or VUS(s) incompatible with the clinical diagnosis. It includes patients' gender, symptom onset age, age at last follow-up, clinical presentation, provisional clinical diagnosis, prior genetic test and results, availability of the WES and WGS data, and WES and WGS of their parents.
The first sheet is the patients that found potential causal variants. The last three columns are...

Dexmedetomidine protects cells from Angiotensin II-induced smooth muscle cell phenotype switch and endothelial cell dysfunction

Min Dai, Xiaohong Zhu, Simin Zeng, Qiang Liu, Ruilin Hu, Lianghui Huang, Yu Wang, Jun Deng & Qi Yu
Abdominal aortic aneurysm (AAA) is a vascular disorder greatly threatening life of the elderly population. Dexmedetomidine (DEX), an α2-adrenergic receptor agonist, has been shown to suppress AAA development. Nevertheless, the signaling pathways that might be mediated by DEX in AAA has not been clarified. Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) were treated with Angiotensin II (Ang II) to mimic AAA in vitro. BrdU, wound healing, and Transwell assays were utilized for measuring...

Supporting data for “Development of Microneedle-based vaccine delivery systems and mRNA-based vaccines”.

Chaiyaporn Kuwentrai
Files are separated by Project Title and date. Each major project has one large file with subfiles inside containing raw data, figures, tables and original images. The overall data represents different experimental results from mRNA-based vaccine research and microneedle-based vaccine delivery research. There are 2 disease subtopics including cancer and COVID-19 (nCoV). Major mRNA studies are about measuring vaccine-related responses in animals and comparing different treatments for cancer and COVID-19. Some important data highlight the...

Registration Year

  • 2022
    456

Resource Types

  • Dataset
    456

Affiliations

  • University of Hong Kong
    456
  • Southern Medical University
    149
  • Zhejiang University
    147
  • Shanghai Jiao Tong University
    147
  • Sichuan University
    138
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    136
  • Peking University
    135
  • West China Hospital of Sichuan University
    127
  • Jilin University
    122
  • Chinese Academy of Sciences
    122