Application of simultaneous selective pressures slows adaptation

Lauren Merlo, Kathleen Sprouffske, Taylor Howard, Kristin Gardiner, Aleah Caulin, Steven Blum, Perry Evans, Antonio Bedalov, Paul Sniegowski & Carlo Maley
Background and objectives: Beneficial mutations that arise in an evolving asexual population may compete or interact in ways that alter the overall rate of adaptation through mechanisms such as clonal or functional interference. The application of multiple selective pressures simultaneously may allow for a greater number of adaptive mutations, increasing the opportunities for competition between selectively advantageous alterations, and thereby reducing the rate of adaptation. Methodology: We evolved a strain of Saccharomyces cerevisiae that could...

Registration Year

  • 2020
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Resource Types

  • Dataset
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Affiliations

  • Fred Hutchinson Cancer Research Center
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  • University of Pennsylvania
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  • Children's Hospital of Philadelphia
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  • Novartis (Switzerland)
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  • Lankenau Institute for Medical Research
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  • Arizona State University
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  • Dana-Farber/Harvard Cancer Center
    1
  • University of Nevada, Las Vegas
    1