Many critical infrastructure systems have network structure and are under stress. Despite their national importance, the complexity of large-scale transport networks means we do not fully understand their vulnerabilities to cascade failures. The research in this paper examines the interdependent rail networks in Greater London and surrounding commuter area. We focus on the morning commuter hours, where the system is under the most demand stress. There is increasing evidence that the topological shape of the...

Zebrafish erythropoietin a (epoa) is a well characterized regulator of red blood cell formation. Recent morpholino mediated knockdown data have also identified epoa being essential for physiological pronephros development in zebrafish, which is driven by blocking apoptosis in developing kidneys. Yet, zebrafish mutants for epoa have not been described so far. In order to compare a transient knockdown vs. permanent knockout for epoa in zebrafish on pronephros development, we used CRISPR/Cas9 technology to generate epoa...

Additional file 2. Supplementary Tables S1, S2, and S3.

The recent extreme volatility in cryptocurrency prices occurred in the setting of popular social media forums devoted to the discussion of cryptocurrencies. We develop a framework that discovers potential causes of phasic shifts in the price movement captured by social media discussions. This draws on principles developed in healthcare epidemiology where, similarly, only observational data are available. Such causes may have a major, one-off effect or recurring effects on the trend in the price series....

We develop a new Data-Driven Phasic Word Identification (DDPWI) methodology to determine which words matter as the bitcoin pricing dynamic changes from one phase to another. With Google search volumes as a baseline, we find that Reddit submissions are both correlated with Google and have a comparable relationship with a variety of bitcoin metrics, using Spearman’s rho. Reddit provides complete access to the text of submissions. Rather than associating sentiment with market activity, we describe...

We present a new dataset for the task of toponym resolution in digitised historical newspapers in English. It consists of 343 annotated articles from newspapers based in four different locations in England (Manchester, Ashton-under-Lyne, Poole and Dorchester), published between 1780 and 1870. The articles have been manually annotated with mentions of places, which are linked---whenever possible---to their corresponding entry on Wikipedia. The dataset is published on the British Library shared research repository, and is especially...

Additional file 2. Supplementary Tables S1, S2, and S3.

Zebrafish erythropoietin a (epoa) is a well characterized regulator of red blood cell formation. Recent morpholino mediated knockdown data have also identified epoa being essential for physiological pronephros development in zebrafish, which is driven by blocking apoptosis in developing kidneys. Yet, zebrafish mutants for epoa have not been described so far. In order to compare a transient knockdown vs. permanent knockout for epoa in zebrafish on pronephros development, we used CRISPR/Cas9 technology to generate epoa...