7 Works

Rule based and information integration category learning

John Freeman & Matthew Broschard
The following dataset includes sessions from rats and humans learning and generalizing to Rule-based and Information Integration categories. Here, category exemplars are Gabor patches, which are circular stimuli that contain black and white gratings. Across exemplars, these gratings can change in their spatial frequency and orientation. For Rule-based tasks, only one stimulus dimension (i.e., spatial frequency or orientation) is category-relevant, and the other dimension varies randomly. For Information Integration tasks, both stimulus dimensions (i.e., spatial...

Data from: Ontogenetic variability in crystallography and mosaicity of conodont apatite: Implications for microstructure, paleothermometry and geochemistry

Mohammad Shohel, Neo McAdams & Bradley Cramer
X-ray diffraction data from Silurian conodonts belonging to various developmental stages of the species Dapsilodus obliquicostatus demonstrate changes in crystallography and degree of nanocrystallite ordering (mosaicity) in both hyaline and albid crown tissue. The exclusive use of a single species in this study, combined with systematic testing of each element type at multiple locations, provided insight into microstructural and crystallographic differentiation between element position (Sa, Sb-c, M) as well as between juveniles and adults. A...

Character data for taxa added to phylogenetic analyses in \"A new crocodylid from the middle Miocene of Kenya and the timing of crocodylian faunal change in the late Cenozoic of Africa\"

Christopher Brochu
Brochuchus is a small crocodylid originally based on specimens from the early Miocene of Rusinga Island, Lake Victoria, Kenya. Here, we report occurrences of Brochuchus from several early and middle Miocene sites. Some are from the Lake Victoria region, and others are in the Lake Turkana Basin. Specimens from the middle Miocene Maboko locality form the basis of a new species, Brochuchus parvidens, which has comparatively smaller maxillary alveoli. Because of the smaller alveoli, the...

Data from: Validation of serum neurofilaments as prognostic & potential pharmacodynamic biomarkers for ALS

Michael Benatar, Lanyu Zhang, Lily Wang, Volkan Granit, Jeffrey Statland, Richard Barohn, Andrea Swenson, John Ravitz, Carlayne Jackson, Ted Burns, Jaya Trivedi, Erik Pioro, James Caress, Jonathan Katz, Jacob McCauley, Rosa Rademakers, Andrea Malaspina, Lyle Ostrow & Joanne Wuu
Objective. Identify preferred neurofilament assays, and clinically validate serum NfL and pNfH as prognostic and potential pharmacodynamic biomarkers relevant to ALS therapy development. Methods. Prospective, multi-center, longitudinal observational study of patients with ALS (n=229), primary lateral sclerosis (PLS, n=20) and progressive muscular atrophy (PMA, n=11). Biological specimens were collected, processed and stored according to strict standard operating procedures (SOPs) 1. Neurofilament assays were performed in a blinded manner by independent contract research organizations (CROs). Results....

Data from: Male phenotypes in a female framework: evidence for degeneration in sperm produced by male snails from asexual lineages

Joseph Jalinsky, John Logsdon & Maurine Neiman
How changes in selective regimes affect trait evolution is an important open biological question. We take advantage of naturally occurring and repeated transitions from sexual to asexual reproduction in a New Zealand freshwater snail species, Potamopyrgus antipodarum, to address how evolution in an asexual content— including the potential for relaxed selection on male-specific traits— influences sperm morphology. The occasional production of male offspring by the otherwise all-female asexual P. antipodarum lineages affords a unique and...

Ectopic expression of BBS1 rescues male infertility, but not retinal degeneration, in a BBS1 mouse model

Matthew Cring
Bardet-Biedl syndrome (BBS) is a rare ciliopathy for which there are no current effective treatments. BBS is a genetically heterogeneous disease, though the M390R mutation in BBS1 is involved in approximately 25% of all genetic diagnoses of BBS. The principle features of BBS include retinal degeneration, obesity, male infertility, polydactyly, intellectual disability, and renal abnormalities. Patients with mutations in BBS genes often present with night blindness within the first decade of life, which progresses to...

Data from: Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice

Joe Lim, Julia Cui, Xueshu Li, Hans-Joachim Lehmler, Dongfang Wang & Haiwei Gu
Polychlorinated biphenyls (PCBs) are ubiquitously detected in the environment and have been linked to metabolic diseases. The liver serves as a central hub for the metabolism of xenobiotics and endogenous metabolites. Gut dysbiosis is recognized as a critical regulator of disease susceptibility, however, little is known regarding how PCBs and gut microbiome interact to modulate the interface between xenobiotic and intermediary metabolism. We hypothesized that the gut microbiome regulates PCBs-mediated changes in the metabolic fingerprints...

Registration Year

  • 2020
    7

Resource Types

  • Dataset
    7

Affiliations

  • University of Iowa
    7
  • University of Washington
    1
  • Southwestern Medical Center
    1
  • Johns Hopkins University
    1
  • University of Virginia
    1
  • University of California, San Diego
    1
  • Wake Forest University
    1
  • Queen Mary University of London
    1
  • California Pacific Medical Center
    1
  • University of Miami
    1