9 Works

Data from: Multispecies invasion reduces the negative impact of single alien plant species on native flora

Magdalena Lenda, Piotr Skórka, Johannes Knops, Michał Żmihorski, Renata Gaj, Dawid Moroń, Michal Woyciechowski & Piotr Tryjanowski
Aim: In the current Anthropocene, many ecosystems are being simultaneously invaded by multiple alien species. Some of these invasive species become more dominant and have greater environmental impacts than others. If two potentially dominant species invade the same area, the combined impact has been reported to be either (1) domination by one species, i.e., the competitive dominance of one invader, or (2) invasion meltdown, where the combined impact is much greater, i.e., a synergistic effect....

Data from: MHC structuring and divergent allele advantage in a urodele amphibian: a hierarchical multi-scale approach

Lorenzo Talarico, Wieslaw Babik, Silvio Marta, Venusta Pietrocini & Marco Mattoccia
The proteins encoded by extraordinarily polymorphic major histocompatibility complex (MHC) genes are involved in the adaptive immune response. Balancing selection is believed to maintain MHC polymorphism in the long-term, although neutral processes also play a role in shaping MHC diversity. However, the relative contribution of these processes is poorly understood. Here we characterized MHC class II variation of a low-dispersal, pond-breeding newt (Triturus carnifex) over a restricted, geographically structured area. We aimed to: (1) evaluate...

Data from: Pervasive introgression of MHC genes in newt hybrid zones

Dudek Katarzyna, Tomasz Gaczorek, Piotr Zieliński & Wieslaw Babik
Variation in the vertebrate major histocompatibility complex (MHC) genes is crucial for fighting pathogen assault. Because new alleles confer a selective advantage, MHC should readily introgress between species, even under limited hybridization. Using replicated transects through two hybrid zones between strongly reproductively isolated European newts, Lissotriton montandoni and L. vulgaris, we demonstrated recent and ongoing MHC class I and II introgression in the Carpathian region. The extent of introgression correlated with the age of contact....

Does operational sex ratio influence relative strength of purging selection in males vs. females?

Agata Plesnar-Bielak, Karolina Sychta, Tomasz S Gaczorek, Joanna K Palka, Monika A Prus & Zofia M Prokop
According to theory, sexual selection in males may efficiently purge mutation load of sexual populations, reducing or fully compensating “the cost of males”. For this to occur, mutations not only need to be deleterious to both sexes, they also must affect males more than females. A frequently overlooked problem is that relative strength of selection on males vs. females may vary between environments, with social conditions being particularly likely to affect selection in males and...

Data from: Key pollen host plants provide balanced diets for wild bee larvae: a lesson for planting flower strips and hedgerows

Michał Filipiak
Bee‐friendly plants are defined by the quantity of food they produce and the visitation rates of adult insects foraging for nectar. However, it is pollen nutritional quality that enables proper larval development of bees, affecting their populations. Not all plants produce pollen that satisfies the nutritional requirements of bee larvae, and we lack an understanding of how different plant pollens impact bee nutritional demands. This study examined whether nutritionally desirable key plant species may promote...

Seasonal shifts of biodiversity patterns and species’ elevation ranges of butterflies and moths along a complete rainforest elevational gradient on Mount Cameroon

Vincent Maicher, Szabolcs Sáfián, Mercy Murkwe, Sylvain Delabye, Łukasz Przybyłowicz, Pavel Potocký, Ishmeal N. Kobe, Štěpán Janeček, Jan E. J. Mertens, Eric B. Fokam, Tomasz Pyrcz, Jiří Doležal, Jan Altman, David Hořák, Konrad Fiedler & Robert Tropek
Aim Temporal dynamics of biodiversity along tropical elevational gradients are unknown. We studied seasonal changes of Lepidoptera biodiversity along the only complete forest elevational gradient in the Afrotropics. We focused on shifts of species richness patterns, seasonal turnover of communities, and seasonal shifts of species’ elevational ranges, the latter often serving as an indicator of the global change effects on mountain ecosystems. Location Mount Cameroon, Cameroon. Taxon Butterflies and moths (Lepidoptera) Methods We quantitatively sampled...

Data from: Birds with high lifetime reproductive success experience increased telomere loss

Joanna Sudyka, Aneta Arct, Szymon M. Drobniak, Lars Gustafsson & Mariusz Cichoń
Lifetime reproductive success (LRS) is what counts in terms of evolution, but investments in reproduction entail costs for an organism. The idea that telomere dynamics may be shaped in response to such costs is already established, however we still lack information if this relation translates to overall fitness. Here, we quantified lifetime reproductive success (number of fledged young) and longitudinal telomere dynamics of small passerine birds - the blue tits. We found that individual telomere...

Data from: Parental genetic similarity and offspring performance in blue tits in relation to brood size manipulation

Aneta Arct, Szymon Drobniak, Samantha Mellinger, Lars Gustafsson & Mariusz Cichon
In birds, as in many other taxa, the level of genetic similarity between parents is an important source of variation in offspring fitness. The majority of avian studies which explore the influence of mates’ genetic similarity on offspring viability have focused on hatching success as a viability measure. Yet, viability benefits may extend into later life stages, including the nestling period and beyond. Here, we analysed data from free-living blue tits (Cyanistes caeruleus) across three...

Data from: Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis

James F. Howard, Vera Bril, Ted M. Burns, Renato Mantegazza, Malgorzata Bilinska, Andrzej Szczudlik, Said Beydoun, Francisco Javier Rodriguez De Rivera Garrido, Fredrik Piehl, Mariarosa Rottoli, Philip Van Damme, Tuan Vu, Amelia Evoli, Miriam Freimer, Tahseen Mozaffar, E. Sally Ward, Torsten Dreier, Peter Ulrichts, Katrien Verschueren, Antonio Guglietta, Hans De Haard, Nicolas Leupin & Jan J. G. M. Verschuuren
Objective: To investigate safety and explore efficacy of efgartigimod (ARGX-113), an anti-neonatal Fc receptor immunoglobulin G1 Fc fragment, in patients with generalized myasthenia gravis (gMG) with a history of anti-acetylcholine receptor (AChR) autoantibodies, who were on stable standard-of-care myasthenia gravis (MG) treatment. Methods: A phase 2, exploratory, randomized, double-blind, placebo-controlled, 15-center study is described. Eligible patients were randomly assigned (1:1) to receive 4 doses over a 3-week period of either 10 mg/kg IV efgartigimod or...

Registration Year

  • 2019
    9

Resource Types

  • Dataset
    9

Affiliations

  • Jagiellonian University
    9
  • Polish Academy of Sciences
    2
  • Uppsala University
    2
  • University of Queensland
    1
  • The Ohio State University
    1
  • University of Milan
    1
  • University of North Carolina
    1
  • University of Virginia
    1
  • Autonomous University of Madrid
    1
  • Texas A&M University
    1