The reduction in biodiversity through land use changes due to urbanization and agricultural intensification, appears linked to major epidemiological changes in many human diseases. Increasing disease risks and the emergence of novel pathogens appear to result from increased contact between wildlife, domesticated animals and humans. We investigate how increasing human domination of the environment may favor generalist and synanthropic rodent species and affect the diversity and prevalence of rodent-borne pathogens in Southeast Asia, a hotspot...