63 Works

Physicans Implement Exercise = Medicine

Rienk Dekker
Data categories: Other, Survey data Material collected: Other Experimental data: Other Number of donors: 159 Sex : Female, Male Age: 18-85 Year Diseases studied: Hemiplegia, unspecified Polyarthrosis, Cervical disc disorders, Myositis

Prevention and Incidence of Asthma and Mite Allergy Study

Gerard Koppelman
The PIAMA-study is a large ongoing population-based cohort study with prenatal inclusion and follow-up until the current age of 18 years. The study was designed to investigate the influence of lifestyle and environment on the development of asthma, allergy and lung function. It therefore contains a detailed characterization of lifestyle and environmental exposures in all stages of childhood.

Kind, Ouders en gezondheid: Aandacht voor Leefstijl en Aanleg

Dirkje Postma & Carel Thijs
birth cohort, extensive environmental measures; 1600 trio's

Technical development in junior speed skaters

Marije Elferink-Gemser
Longitudinal and cross-sectional data of technique development during a 1500m for junior speed skaters. Observational data from healthy people.

MeDAS PET: a non-invasive imaging tool for quantitative assessment of myelin loss in multiple sclerosis

Erik de Vries
PET and MR imaging dataset of patients (n=10) with primary and secondary progressive multiple sclerosis.


Stephan Bakker
Transplantation is a very successful and life-saving treatment. Yet, after transplantation, many transplant recipients face a multitude of health problems, impairing quality of life, length of life and duration of organ function. TransplantLines is a biobank aiming at finding biomarkers for early and non-invasive detection of health problems and yet unsolved questions that transplantation patients face.

Data from: Productive activities, mental health and quality of life in disability: exploring the role enhancement and the role strain hypotheses

Christine Fekete, Johannes Siegrist, Marcel W. M. Post & Martin W. G. Brinkhof
Background: Engagement in productive activities is an important determinant of mental health and quality of life (QoL). Persons with physical disabilities are often confronted with constraints to engage in productive activities and it remains largely unknown whether persons who nevertheless manage to be productive experience beneficial effects for mental health and QoL. This is the first study to analyse different productive activities (paid work, volunteering, education, housework) and its gender-specific associations with mental health and...

Globalizing medical knowledge and practise. Doctor-patient-interaction videoobserved at a university hospital in Groningen (Netherlands). Transcripts, translation, audiovisual and context material

Anja Weiß, Ilka Sommer, Stefanie Merse, Sarah Weingartz, Götz Wietasch, Alexander Maass & Solmaz Assa
DE: Der Datensatz enthält 18 Beobachtungen von Ärzten und Ärztinnen, die eine_n Simulationspatienten/in (SP) behandeln, der bzw. die Herzinsuffizenz simuliert, ein weit verbreitetes kardiologisches Syndrom. Die Arzt-Patient-Interaktionen fanden 2020 am University Medical Center Groningen (UMCG) in Groningen (Niederlande) statt. Die teilnehmenden Ärzte und Ärztinnen waren in Bezug auf Berufserfahrung, Spezialisierungsgrad, Fachsprache, Alter, Geschlecht und Migrationserfahrung divers. Diese Merkmale liegen als Fragebogendaten vor. Die Studie verwendete zwei Skripte für die SPs: Ein Fall von systolischer Herzinsuffizienz...

Vlagtwedde-Vlaardingen Study

H.M. Boezen
In 1965 one of the first large epidemiological studies started in the Netherlands: the population study in Vlagtwedde and Vlaardingen. Over 8000 people took part. The cohort study was concluded in 1990, but the data from the databank still provide useful information in the research into the origin of lung diseases. For instance, follow-up research into mortality in this cohort has resulted in the discovery that people with a higher airway sensitivity have a greater...

Predictive value of the microlesion effect on motor and cognitive outcome after Deep Brain Stimulation in Parkinson’s Disease

J. Marc C. van Dijk & T. van Laar
Study to investigate the motor and cognitive effects of inserting a Deep Brain Stimulation electrode into the brain of a Parkinson’s disease patient.


Rinse Weersma
The department of Gastroenterology and Hepatology of the University Medical Center Groningen initiated the 1000IBD project to prospectively follow more than a 1000 IBD patients from the Northern provinces of the Netherlands. We have collected a uniquely large number of phenotypes and generated multi-omics profiles for these patients. To date, 1,215 participants have been enrolled in the 1000IBD project, and enrolment is on-going. Patients that participate in the 1000IBD project are followed prospectively and the...

Lifelines DEEP Food intake

Daily nutrient intake (energy(kcal), energy (kJ), total protein (g), plant protein (g), animal protein (g), total fat (g), total carbohydrates (g), total alcohol (g), total protein (en%), plant protein (en%), animal protein (en%), total fat (en%), total carbohydrates (en%), total alcohol (en%),) Lifelines DEEP participants

Groningen Expert Center for Kids with Obesity

Eva Corpeleijn
The overall aim of the GECKO Drenthe cohort is to study the prevalence and early risk factors for the development of childhood overweight and fat distribution at very young age. Within this birth cohort the growth of the children is closely followed, starting at birth until adulthood. The children are followed using questionnaires that the parents have to answer and the regular visits to the Well Baby Clinics, where length, weight, head circumference and hip...

Prehabilitation in Amutees

Rienk Dekker, Jan Geertzen & Juha Hijmans
Sex: Female, Male Diseases studied: Care involving use of other rehabilitation procedures

Data from: Intestinal Ralstonia pickettii augments glucose intolerance in obesity

Shanthadevi Udayappan, Petia Kovatcheva-Datchary, Guido Bakker, Stefan Havik, Hilde Herrema, Patrice Cani, Kristien Bouter, Clara Belzer, Julia J. Witjes, Anne Vrieze, Eleonore Susanne Victoria De Sonnaville, Alice Chaplin, Daniel Van Raalte, Steven Aalvink, Geesje Dallinga-Thie, Hans Heilig, Goran Bergstrom, Suzan Van Der Meij, Bart Van Wagensveld, Joost Hoekstra, Frits Holleman, Erik Stroes, Albert Groen, Fredrik Backhed, Willem De Vos … & Daniel H. Van Raalte
An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA...

Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infants

Sanne Arjaans, Brandie Wagner, Peter Mourani, Erica Mandell, Brenda Poindexter, Rolf Berger & Steven Abman
Introduction: Early pulmonary vascular disease in preterm infants is associated with the subsequent development of bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH), however, mechanisms that contribute to or identify infants with increased susceptibility for BPD and/or PH are incompletely understood. Therefore, we tested if changes in circulating angiogenic peptides during the first week of life are associated with the later development of BPD and/or PH. We further sought to determine alternate peptides and related signalling...

Data from: A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes

Xiaojing Chu, Yang Li, Cees Tack, Anna Janssen & Hans Koenen
Background: The large inter-individual variability in immune-cell cell composition and function determines immune responses in general and susceptibility to immune-mediated diseases in particular. While much has been learned about the genetic variants relevant for type 1 diabetes (T1D), the pathophysiological mechanisms through which these variations exert their effects remain unknown. Methods: Blood samples were collected from 243 patients with T1D of Dutch descent. We applied genetic association analysis on > 200 immune cell traits and...

Master Your symptoms: personalized online Self-help for somatic symptom disorder

Denise Hanssen
Data categories: Survey data Number of donors: 33 Sex: Male, Female Age: 27-69 Year

Data from: Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

Natanja Oosterom, Pieter H. Griffioen, Marissa A. H. Den Hoed, Rob Pieters, Robert De Jonge, Wim J.E. Tissing, Marry M. Van Den Heuvel-Eibrink, Sandra G. Heil & Wim J. E. Tissing
BACKGROUND Children with acute lymphoblastic leukemia (ALL) often suffer from toxicity of chemotherapeutic drugs such as Methotrexate (MTX). Previously, we reported that 20% of patients receiving high-dose MTX developed oral mucositis. MTX inhibits folate metabolism, which is essential for DNA methylation. We hypothesize that MTX inhibits DNA methylation, which results into adverse effects. We studied DNA methylation markers during high-dose methotrexate treatment in pediatric acute lymphoblastic leukemia (ALL) in relation to developing oral mucositis. MATERIALS...

Data from: Statin use and cognitive function: population-based observational study with long-term follow-up

Hanneke Joosten, Sipke T. Visser, Marlise E. Van Eersel, Ron T. Gansevoort, Henk J. Bilo, Joris P. Slaets, Gerbrand J. Izaks & Henk J. G. Bilo
We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0; best score, 175 points) and the Visual Association Test (VAT; low performance, 0–10; high performance, 11–12 points) in an observational study that included 4,095 community-dwelling participants aged 35–82 years. Data on statin use were obtained from a computerized pharmacy database. Analysis were done for the total cohort and subsamples...

Prevention of Renal and Vascular End-stage Disease

Ron Gansevoort
Prospective cohort; focus on renal and cardiovascular disease. 8592 subjects measured at baseline and during 5 follow-up screening rounds.

Universitair Medisch Centrum Groningen - Chronic Obstructive Pulmonary Disease

Dirkje Postma & Gerard Koppelman
100 asthmatics followed from childhood over 30 years, 280 asthma patients with follow up >30 years from which 200 families with proband with asthma (n=1259), 200 unrelated asthma, asthma trios (n=405), Rhinitis trios (n=226), untreated asthma and controls (n=150), 200 asthmapatients with airway biopsies, followed over >5 years), 75 families with two children with asthma.

Self-monitoring and personalized feedback as a tool to boost depression treatment

Jojanneke Bastiaansen
Pragmatic randomized controlled trial to study the efficacy of two experience sampling intervention modules for depression.

Evaluation of systemic awareness training for medical students

Salome Scholtens & Joke Fleer
Data categories: Survey data Material collected: Not available Experimental data: Not available Number of donors: 373 Sex: Female, Male Age: 19-29 Year

Genetics database

Registration Year

  • 2022
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  • 2013

Resource Types

  • Dataset


  • University Medical Center Groningen
  • University of Groningen
  • VU University Medical Center
  • Erasmus University Medical Center
  • Maastricht University Medical Centre
  • Maastricht University
  • University of Copenhagen
  • University of Helsinki
  • Swiss Paraplegic Research
  • University of Innsbruck