Nonalcoholic fatty liver disease (NAFLD), a chronic and progressive liver disease, often causes steatosis and steatohepatitis. Qi-Ge decoction (QGD) shows a good effect against NAFLD in the clinic. But the molecular mechanism for QGD in improving NAFLD is unknown. This study explored the molecular mechanism of QGD in NAFLD model rats using comprehensive network pharmacology, molecular docking and in vivo verification strategies. Active components and targets of QGD were obtained from public database. The overlapped...

High dimensional linear models are commonly used in practice. In many applications, one is interested in linear transformations β⊤x of regression coefficients β∈Rp, where x is a specific point and is not required to be identically distributed as the training data. One common approach is the plug-in technique which first estimates β, then plugs the estimator in the linear transformation for prediction. Despite its popularity, estimation of β can be difficult for high dimensional problems....

Additional file 4.

Additional file 6: Table S1. Mean performance of the plant height and panicle architecture trait of the nine genotypes in NIL-F2 population from the cross between NIL-ep4.2 and NIL-dep7.

Additional file 10: Table S5. Interaction analysis between EP4.2 and DEP8 in NIL-F2 population

Additional file 10: Table S5. Interaction analysis between EP4.2 and DEP8 in NIL-F2 population

Additional file 8: Table S3. Mean performance of the plant height and panicle architecture trait of the nine genotypes in NIL-F2 population from the cross between NIL-dep7 and NIL-dep8

Molecular dynamics simulation and sensitivity analysis results

Supplementary material

Additional file 2: Raw data.

Additional file 2: Table S1. Data qualities statistics of RNA-seq in eggplant flesh.

Additional file 2: Table S1. Simulated validation in canonical datasets.

Additional file 2: Table S1. Simulated validation in canonical datasets.

Additional file 4: Table S3. Centromere regions in human and Arabidopsis thaliana.

Additional file 4: Table S3. Centromere regions in human and Arabidopsis thaliana.

Supplementary Table 1. Summary of information for a whale pharyngeal metagenomic library.

Supplementary Material 8

Additional file 4. Additional Table, supplementary Table 4, the qualitative differences between SCCC and normal tissues.

Additional file 1: Table S1. Primers used in this study. Table S2. COG annotation results. Table S3. Annotation results of mitochondria metabolism.

Additional file 2:Table S1. The basic informations and sequencing data of NK-AML (M4/M5) patients and healthy donors.

Additional file 2: Table S2. Primers developed for six CsLAC genes for qRT‒PCR and CsLAC3 for subcellular localization.

Additional file 5: Table S1. The specific primers for qRT-PCR.

Additional file 8. Correlation analysis between PD-L1 expression and DEMGs expression.

Additional file 9. The LASSO regression coefficient of five DEMGs.

Additional file 1.