4 Works
Stress: better coping associated with lower tau in amyloid positive cognitively unimpaired older adults
Eider Arenaza-Urquijo
Objective: Research in animals has shown that chronic stress exacerbates tau pathology. In humans, psychological stress has been associated with higher risk of Alzheimer’s disease (AD) clinical syndrome. The objective of this cross-sectional study was to assess the hypothesis that stress coping ability (assessed via the “Brief Resilience Scale” [BRS]) is associated with tau burden and to evaluate whether these associations differed by sex and amyloid status (A+/A-) in cognitively unimpaired older adults (CU). Methods:...
Data from: Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials
Leonard H Van Den Berg, Eric Sorenson, Gary Gronseth, Eric A. Macklin, Jinsy Andrews, Robert H. Baloh, Michael Benatar, James D. Berry, Adriano Chio, Philippe Corcia, Angela Genge, Amelie K. Gubitz, Catherine Lomen-Hoerth, Christopher J. McDermott, Erik P. Pioro, Jeffrey Rosenfeld, Vincenzo Silani, Martin R. Turner, Markus Weber, Benjamin Rix Brooks, Robert G. Miller & Hiroshi Mitsumoto
Objective: To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS). Methods: A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patient representatives, research funding representatives, industry and regulatory agencies) addressed nine areas of need within ALS research: 1. Pre-clinical studies; 2. Biological and phenotypic heterogeneity; 3. Outcome measures; 4. Disease-modifying and symptomatic interventions;...
Clinical and pathological features of cognitive-predominant corticobasal degeneration
Dennis Dickson
OBJECTIVE: To describe clinical and pathological characteristics of CBD with cognitive predominant problem during the disease course. METHODS: In a series of autopsy-confirmed cases of CBD, we identified patients with cognitive rather than motor predominant features (CBD-Cog), including five patients thought to have Alzheimer disease (AD) (CBD-AD) and ten patients thought to have behavioral variant frontotemporal dementia (FTD) (CBD-FTD). We compare clinical and pathological features of CBD-Cog with those from a series of 31 patients...
Data from: Test collections for EHR-based clinical information retrieval
Yanshan Wang, Andrew Wen, Sijia Liu, William Hersh, Steven Bedrick & Hongfang Liu
Objectives: To create test collections for evaluating clinical Information Retrieval (IR) systems and advancing clinical IR research. Materials and Methods: Electronic Health Records (EHR) data, including structured and free text data, from 45,000 patients who are a part of the Mayo Clinic Biobank cohort was retrieved from the clinical data warehouse. The clinical IR system indexed 42 million free-text EHR documents. The search queries consisted of 56 topics developed through a collaboration between Mayo Clinic...