2 Works

Modulation of fracture healing by the transient accumulation of senescent cells

Dominik Saul, David Monroe, Jennifer Rowsey, Robyn Kosinsky, Stephanie Vos, Madison Doolittle, Joshua Farr, Sundeep Khosla, David G Monroe, Jennifer L Rowsey, Robyn Laura Kosinsky, Stephanie J Vos, Madison L Doolittle & Joshua N Farr
Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined. Here, we performed an in silico analysis of public mRNAseq data and found that senescence and senescence-associated secretory phenotype (SASP) markers increased during fracture healing. We next directly established that the expression of senescence biomarkers increased markedly during murine...

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Dominik Saul
Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype (SASP), in vivo senescent cell identification remains challenging. Here, we generated a gene set (SenMayo) and validated its enrichment in bone biopsies from two aged human cohorts. We further demonstrated reductions in SenMayo in bone following genetic clearance of senescent cells in mice and in adipose tissue from humans following pharmacological senescent cell clearance. We next used SenMayo to identify senescent hematopoietic or...

Registration Year

  • 2022

Resource Types

  • Dataset


  • Mayo Clinic
  • Mayo Clinic