Data from: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity
Isaac M. Chiu, Lee B. Barrett, Erika Williams, David E. Strochlic, Seungkyu Lee, Andy D. Weyer, Shan Lou, Gregory Bryman, David P. Roberson, Nader Ghasemlou, Cara Piccoli, Ezgi Ahat, Victor Wang, Enrique J. Cobos, Cheryl L. Stucky, Qiufu Ma, Stephen D. Liberles, Clifford J. Woolf & Gregory S Bryman
The somatosensory nervous system is critical for the organism’s ability to respond to mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are functionally and anatomically diverse but their molecular profiles are not well-defined. Here, we used transcriptional profiling to analyze the detailed molecular signatures of dorsal root ganglion (DRG) sensory neurons. We used two mouse reporter lines and surface IB4 labeling to purify three major non-overlapping classes of neurons: 1)IB4+SNS-Cre/TdTomato+, 2)IB4-SNS-Cre/TdTomato+, and 3)Parv-Cre/TdTomato+ cells, encompassing the...