5 Works

Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation

Henning J Falk, Takehito Tomita, Gregor Moenke, Katie McDole & Alexander Aulehla
A fundamental requirement for embryonic development is the coordination of signaling activities in space and time. A notable example in vertebrate embryos is found during somitogenesis, where gene expression oscillations linked to the segmentation clock are synchronized across cells in the presomitic mesoderm (PSM) and result in tissue-level wave patterns. To examine their onset during mouse embryo development, we studied the dynamics of the segmentation clock gene Lfng during gastrulation. To this end, we established...

Dynamic encoding of social threat and spatial context in the hypothalamus - calcium activity recordings and behavioural dataset

Piotr Krzywkowski
Social aggression and avoidance are defensive behaviors expressed by territorial animals in a manner appropriate to spatial context and experience. The ventromedial hypothalamus controls both social aggression and avoidance, suggesting that it may encode an general internal state of threat modulated by space and experience. Here we show that neurons in the mouse ventromedial hypothalamus are activated both by the presence of a social threat as well as by a chamber where social defeat previously...

Data from: Development of the annelid axochord: insights into notochord evolution

Antonella Lauri, Thibaut Brunet, Mette Handberg-Thorsager, Antje H. L. Fischer, Oleg Simakov, Patrick R. H. Steinmetz, Raju Tomer, Philipp J. Keller & Detlev Arendt
The origin of chordates has been debated for more than a century, with one key issue being the emergence of the notochord. In vertebrates, the notochord develops by convergence and extension of the chordamesoderm, a population of midline cells of unique molecular identity. We identify a population of mesodermal cells in a developing invertebrate, the marine annelid Platynereis dumerilii, that converges and extends toward the midline and expresses a notochord-specific combination of genes. These cells...

Data from: Complex evolution of insect insulin receptors and homologous decoy receptors, and functional significance of their multiplicity

Vlastimil Smýkal, Martin Pivarči, Jan Provazník, Olga Bazalová, Pavel Jedlička, Ondřej Lukšan, Aleš Horák, Hana Vaněčková, Vladimír Beneš, Ivan Fiala Fiala, Robert Hanus & David Doležel
Evidence accumulates that the functional plasticity of insulin and insulin-like growth factor signaling in insects could spring, among others, from the multiplicity of insulin receptors (InRs). Their multiple variants may be implemented in the control of insect polyphenism, such as wing or caste polyphenism. Here, we present a comprehensive phylogenetic analysis of insect InR sequences in 118 species from 23 orders and investigate the role of three InRs identified in the linden bug, Pyrrhocoris apterus,...

Transcriptome dataset to: Chemical genetics in Silene latifolia elucidate regulatory pathways involved in gynoecium development

Václav Bačovský, Radim Čegan, Eva Tihlaříková, Vilém Neděla, Vojtěch Hudzieczek, Lubomír Smrža, Tomáš Janíček, Vladimír Beneš & Roman Hobza
This collection contains RNA-seq data obtained from young flower buds of Silene latifolia for each sample in the main manuscript in triplicate (male, female, two generations of hermaphrodites). The RNA was isolated from adult plants of U15 population and two subsequent generations, made by full-sib mating (U15=15 generations, U16=16 generations, U17=17 generations). The petals and sepals were removed before RNA-isolation. To avoid the bias made by sampling of old flower buds, only the first flowers...

Registration Year

  • 2022
  • 2021
  • 2020
  • 2014

Resource Types

  • Dataset


  • European Molecular Biology Laboratory
  • Institute of Biophysics
  • MRC Laboratory of Molecular Biology
  • Janelia Farm Research Campus
  • Institute of Scientific Instruments
  • Academy of Sciences of the Czech Republic