Data from: Detection of human adaptation during the past 2000 years

Yair Field, Evan A. Boyle, Natalie Telis, Ziyue Gao, Kyle J. Gaulton, David Golan, Loic Yengo, Ghislain Rocheleau, Philippe Froguel, Mark I. McCarthy & Jonathan K. Pritchard
Detection of recent natural selection is a challenging problem in population genetics. Here we introduce the Singleton Density Score (SDS), a method to infer very recent changes in allele frequencies from contemporary genome sequences. Applied to data from the UK10K Project, SDS reflects allele frequency changes in the ancestors of modern Britons during the past ~2,000-3,000 years. We see strong signals of selection at lactase and the MHC, and in favor of blond hair and...

Registration Year

  • 2016
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  • Dataset
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Affiliations

  • Stanford University
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  • University of Lille
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  • Oxford Centre for Diabetes, Endocrinology and Metabolism
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